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Olle Melander

Principal investigator

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TET2 and CSMD1 genes affect SBP response to hydrochlorothiazide in never-treated essential hypertensives.

Author

  • Martina Chittani
  • Roberta Zaninello
  • Chiara Lanzani
  • Francesca Frau
  • Maria F Ortu
  • Erika Salvi
  • Giovanni Fresu
  • Lorena Citterio
  • Daniele Braga
  • Daniela A Piras
  • Simona Delli Carpini
  • Dinesh Velayutham
  • Marco Simonini
  • Giuseppe Argiolas
  • Simona Pozzoli
  • Chiara Troffa
  • Valeria Glorioso
  • Kimmo K Kontula
  • Timo P Hiltunen
  • Kati M Donner
  • Stephen T Turner
  • Eric Boerwinkle
  • Arlene B Chapman
  • Sandosh Padmanabhan
  • Anna F Dominiczak
  • Olle Melander
  • Julie A Johnson
  • Rhonda M Cooper-Dehoff
  • Yan Gong
  • Natalia V Rivera
  • Gianluigi Condorelli
  • Bruno Trimarco
  • Paolo Manunta
  • Daniele Cusi
  • Nicola Glorioso
  • Cristina Barlassina

Summary, in English

Thiazide diuretics have been recommended as a first-line antihypertensive treatment, although the choice of 'the right drug in the individual essential hypertensive patient' remains still empirical. Essential hypertension is a complex, polygenic disease derived from the interaction of patient's genetic background with the environment. Pharmacogenomics could be a useful tool to pinpoint gene variants involved in antihypertensive drug response, thus optimizing therapeutic advantages and minimizing side effects.

Department/s

  • Cardiovascular Research - Hypertension
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2015

Language

English

Pages

1301-1309

Publication/Series

Journal of Hypertension

Volume

33

Issue

6

Document type

Journal article

Publisher

Lippincott Williams & Wilkins

Topic

  • Cardiac and Cardiovascular Systems

Status

Published

Research group

  • Cardiovascular Research - Hypertension

ISBN/ISSN/Other

  • ISSN: 1473-5598