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Olle Melander

Principal investigator

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Risk prediction by genetic risk scores for coronary heart disease is independent of self-reported family history.

Author

  • Hayato Tada
  • Olle Melander
  • Judy Z Louie
  • Joseph J Catanese
  • Charles M Rowland
  • James J Devlin
  • Sekar Kathiresan
  • Dov Shiffman

Summary, in English

Genetic risk scores (GRSs) have been associated with coronary heart disease (CHD) in large studies. We asked whether expanding an established 27-variant GRS (GRS27) to a 50-variant GRS (GRS50) improved CHD prediction and whether GRSs are independent of self-reported family history of CHD.

Department/s

  • Cardiovascular Research - Hypertension
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2015-09-20

Language

English

Publication/Series

European Heart Journal

Document type

Journal article

Publisher

Oxford University Press

Topic

  • Cardiac and Cardiovascular Systems

Status

Published

Research group

  • Cardiovascular Research - Hypertension

ISBN/ISSN/Other

  • ISSN: 1522-9645