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Olle Melander

Principal investigator

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Polymorphisms in α- And β-adrenergic receptor genes, hypertension, and obstructive sleep apnea : The skaraborg sleep study

Author

  • Kristina Bengtsson Boström
  • Jan Hedner
  • Ludger Grote
  • Olle Melander
  • Fredrik Von Wowern
  • Lennart Råstam
  • Leif Groop
  • Ulf Lindblad

Summary, in English

The sympathetic nervous system and the adrenergic receptors play an important role in regulation of blood pressure. This study explored the associations between functional polymorphisms of the α 2B -, β 1 -, and β 2 -adrenergic receptor genes and obstructive sleep apnea (OSA) in hypertensive patients and hypertension in patients with OSA in a populationbased sample of 157 hypertensive patients and 181 healthy control subjects. Only the Arg389Gly polymorphism of the β 1 -adrenergic receptor gene was associated with increased risk for mild OSA in hypertensive patients (Arg/Arg versus Gly/Arg/Gly/Gly, 2.1, 95% CI, 1.02-4.7). Hypertensive men carrying the Arg389Arg genotype had higher crude and age-adjusted AHI than carriers of the Arg389Gly/Gly389Gly genotypes. When adjusted also for BMI this difference became borderline significant. This difference was not observed in women. The risk of hypertension in mild OSA was associated with increasing number of Arg-alleles (Arg/Arg OR 5.4, 95 CI 1.4-21.2).

Department/s

  • EXODIAB: Excellence in Diabetes Research in Sweden
  • Family Medicine and Community Medicine
  • Genomics, Diabetes and Endocrinology
  • Department of Clinical Sciences, Malmö

Publishing year

2010-12-01

Language

English

Publication/Series

International Journal of Hypertension

Volume

2010

Document type

Journal article

Publisher

Hindawi Limited

Topic

  • Cardiac and Cardiovascular Systems

Status

Published

Research group

  • Family Medicine and Community Medicine
  • Genomics, Diabetes and Endocrinology

ISBN/ISSN/Other

  • ISSN: 2090-0384