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Olle Melander

Principal investigator

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Cellular dehydration acutely degrades mood mainly in women : A counterbalanced, crossover trial

Author

  • Hyun Gyu Suh
  • Harris R. Lieberman
  • Lisa T. Jansen
  • Abigail T. Colburn
  • J. D. Adams
  • Adam D. Seal
  • Cory L. Butts
  • Tracie M. Kirkland
  • Olle Melander
  • Tiphaine Vanhaecke
  • Alberto Dolci
  • Guillaume Lemetais
  • Erica T. Perrier
  • Stavros A. Kavouras

Summary, in English

It is unclear if mild-to-moderate dehydration independently affects mood without confounders like heat exposure or exercise. This study examined the acute effect of cellular dehydration on mood. Forty-nine adults (55 % female, age 39 (SD 8) years) were assigned to counterbalanced, crossover trials. Intracellular dehydration was induced with 2-h (0·1 ml/kg per min) 3 % hypertonic saline (HYPER) infusion or 0·9 % isotonic saline (ISO) as a control. Plasma osmolality increased in HYPER (pre 285 (SD 3), post 305 (SD 4) mmol/kg; P < 0·05) but remained unchanged in ISO (pre 285 (SD 3), post 288 (SD 3) mmol/kg; P > 0·05). Mood was assessed with the short version of the Profile of Mood States Questionnaire (POMS). The POMS sub-scale (confusion-bewilderment, depression-dejection, fatigue-inertia) increased in HYPER compared with ISO (P < 0·05). Total mood disturbance score (TMD) assessed by POMS increased from 10·3 (SD 0·9) to 16·6 (SD 1·7) in HYPER (P < 0·01), but not in ISO (P > 0·05). When TMD was stratified by sex, the increase in the HYPER trial was significant in females (P < 0·01) but not in males (P > 0·05). Following infusion, thirst and copeptin (surrogate for vasopressin) were also higher in females than in males (21·3 (SD 2·0), 14·1 (SD 1·4) pmol/l; P < 0·01) during HYPER. In conclusion, cellular dehydration acutely degraded specific aspects of mood mainly in women. The mechanisms underlying sex differences may be related to elevated thirst and vasopressin.

Department/s

  • Cardiovascular Research - Hypertension
  • EpiHealth: Epidemiology for Health
  • EXODIAB: Excellence in Diabetes Research in Sweden

Publishing year

2021-05-28

Language

English

Pages

1092-1100

Publication/Series

British Journal of Nutrition

Volume

125

Issue

10

Document type

Journal article

Publisher

Cambridge University Press

Topic

  • Nutrition and Dietetics

Keywords

  • Copeptin
  • Osmotic stimulation
  • Thirst
  • Underhydation
  • Vasopressin

Status

Published

Research group

  • Cardiovascular Research - Hypertension

ISBN/ISSN/Other

  • ISSN: 0007-1145