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Olle Melander

Principal investigator

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Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure

Author

  • Christopher Newton-Cheh
  • Martin G. Larson
  • Ramachandran S. Vasan
  • Daniel Levy
  • Kenneth D. Bloch
  • Aarti Surti
  • Candace Guiducci
  • Sekar Kathiresan
  • Emelia J. Benjamin
  • Joachim Struck
  • Nils G. Morgenthaler
  • Andreas Bergmann
  • Stefan Blankenberg
  • Frank Kee
  • Peter Nilsson
  • Xiaoyan Yin
  • Leena Peltonen
  • Erkki Vartiainen
  • Veikko Salomaa
  • Joel N. Hirschhorn
  • Olle Melander
  • Thomas J. Wang

Summary, in English

We examined the association of common variants at the NPPA-NPPB locus with circulating concentrations of the natriuretic peptides, which have blood pressure-lowering properties. We genotyped SNPs at the NPPA-NPPB locus in 14,743 individuals of European ancestry, and identified associations of plasma atrial natriuretic peptide with rs5068 (P = 8 x 10(-70)), rs198358 (P = 8 x 10(-30)) and rs632793 (P = 2 x 10(-10)), and of plasma B-type natriuretic peptide with rs5068 (P = 3 x 10(-12)), rs198358 (P = 1 x 10(-25)) and rs632793 (P = 2 x 10(-68)). In 29,717 individuals, the alleles of rs5068 and rs198358 that showed association with increased circulating natriuretic peptide concentrations were also found to be associated with lower systolic (P = 2 x 10(-6) and 6 x 10(-5), respectively) and diastolic blood pressure (P = 1 x 10(-6) and 5 x 10(-5)), as well as reduced odds of hypertension (OR = 0.85, 95% CI = 0.79-0.92, P = 4 x 10(-5); OR = 0.90, 95% CI = 0.85-0.95, P = 2 x 10(-4), respectively). Common genetic variants at the NPPA-NPPB locus found to be associated with circulating natriuretic peptide concentrations contribute to interindividual variation in blood pressure and hypertension.

Department/s

  • Department of Clinical Sciences, Malmö
  • Cardiovascular Research - Hypertension

Publishing year

2009

Language

English

Pages

348-353

Publication/Series

Nature Genetics

Volume

41

Issue

3

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Cardiac and Cardiovascular Systems

Status

Published

Research group

  • Cardiovascular Research - Hypertension

ISBN/ISSN/Other

  • ISSN: 1546-1718