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Olle Melander

Principal investigator

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The association of single nucleotide polymorphisms (SNPs) with breast density and breast cancer survival : the Malmö Diet and Cancer Study

Author

  • Hanna Sartor
  • Jasmine Brandt
  • Felix Grassmann
  • Mikael Eriksson
  • Kamila Czene
  • Olle Melander
  • Sophia Zackrisson

Summary, in English

Background: Genetic factors are important in determining breast density, and heritable factors account for 60% of the variation. Certain single nucleotide polymorphisms (SNPs) are associated with density and risk of breast cancer but the association with prognosis is not clear. Purpose: To investigate associations between selected SNPs and breast cancer survival in the Malmö Diet and Cancer Study (MDCS). Material and Methods: A total of 724 unrelated women with breast cancer and registered radiological and pathological data were identified in MDCS 1991–2007, with genotyping available for 672 women. Associations among 15 SNPs, density, and breast cancer-specific survival were analyzed using logistic/Cox regression, adjusted for factors affecting density and survival. Variants significantly associated with either density or survival were validated in a large independent breast cancer cohort (LIBRO-1). Results: Minor homozygotes of SNPs rs9383589, CCDC170 and rs6557161, ESR1 were associated with high breast density (adjusted odds ratio [AOR] 8.97, 95% confidence interval [CI] 1.35–59.57; AOR 2.08, 95% CI 1.19–3.65, respectively) and poorer breast cancer survival (adjusted hazard ratio [HRadj] 6.46, 95% CI 1.95–21.39; HRadj 2.30, 95% CI 1.33–3.96, respectively) compared to major homozygotes. For SNP rs3757318, ESR1, minor homozygotes (HRadj 7.46, 95% CI 2.28–24.45) were associated with poorer survival. We confirmed that rs6557161, ESR1 was significantly associated with both density and survival in the LIBRO-1 study. Conclusion: These findings support a shared genetic basis for density and breast cancer survival. The SNP significantly associated with both density and survival in both cohorts may be of interest in future research investigating polygenic risk scores for breast cancer risk and screening stratification purposes.

Department/s

  • Radiology Diagnostics, Malmö
  • LUCC - Lund University Cancer Centre
  • Surgery
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health
  • Cardiovascular Research - Hypertension

Publishing year

2020-10-01

Language

English

Pages

1326-1334

Publication/Series

Acta Radiologica

Volume

61

Issue

10

Document type

Journal article

Publisher

SAGE Publications

Topic

  • Cancer and Oncology

Keywords

  • breast
  • epidemiology
  • Mammography
  • normal variants
  • primary neoplasms
  • screening

Status

Published

Research group

  • Radiology Diagnostics, Malmö
  • Surgery
  • Cardiovascular Research - Hypertension

ISBN/ISSN/Other

  • ISSN: 0284-1851