The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Ola Hansson

Ola Hansson

Principal investigator

Ola Hansson

Genome-wide association analyses highlight etiological differences underlying newly defined subtypes of diabetes

Author

  • Dina Mansour Aly
  • Om Prakash Dwivedi
  • Rashmi B Prasad
  • Annemari Käräjämäki
  • Rebecka Hjort
  • Manonanthini Thangam
  • Mikael Åkerlund
  • Anubha Mahajan
  • Miriam S Udler
  • Jose C Florez
  • Mark I McCarthy
  • Julia Brosnan
  • Olle Melander
  • Sofia Carlsson
  • Ola Hansson
  • Tiinamaija Tuomi
  • Leif Groop
  • Emma Ahlqvist

Summary, in English

Type 2 diabetes has been reproducibly clustered into five subtypes with different disease progression and risk of complications; however, etiological differences are unknown. We used genome-wide association and genetic risk score (GRS) analysis to compare the underlying genetic drivers. Individuals from the Swedish ANDIS (All New Diabetics In Scania) study were compared to individuals without diabetes; the Finnish DIREVA (Diabetes register in Vasa) and Botnia studies were used for replication. We show that subtypes differ with regard to family history of diabetes and association with GRS for diabetes-related traits. The severe insulin-resistant subtype was uniquely associated with GRS for fasting insulin but not with variants in the TCF7L2 locus or GRS reflecting insulin secretion. Further, an SNP (rs10824307) near LRMDA was uniquely associated with mild obesity-related diabetes. Therefore, we conclude that the subtypes have partially distinct genetic backgrounds indicating etiological differences.

Department/s

  • EXODIAB: Excellence of Diabetes Research in Sweden
  • Genomics, Diabetes and Endocrinology
  • Diabetic Complications
  • EpiHealth: Epidemiology for Health
  • Cardiovascular Research - Hypertension

Publishing year

2021

Language

English

Pages

1534-1542

Publication/Series

Nature Genetics

Volume

53

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Endocrinology and Diabetes

Keywords

  • ANDIS
  • diabetes

Status

Published

Research group

  • Genomics, Diabetes and Endocrinology
  • Diabetic Complications
  • Cardiovascular Research - Hypertension

ISBN/ISSN/Other

  • ISSN: 1546-1718