Ola Hansson, PI
Our research interest is to understand how genetic variation influences skeletal muscle function and whole-body metabolism. We use translational approaches and regularly conduct focused intervention studies in humans, including skeletal muscle biopsies. From the biopsies, muscle stem cells (satellite cells) are isolated and later used for preclinical measurements. In our projects we combine physiological measurements like VO2MAX, muscular strength and glucose tolerance with preclinical, e.g. RNA and ChIP sequencing, fibre typing, gene knock down and exon skipping. It is our hope that this research will lead to new understanding of skeletal muscle function with implications primarily for human health, but also provide answers to fundamental evolutionary questions. A long-term goal is to tailor the most beneficial exercise program to counteract genetic predisposition to metabolic diseases and type 2 diabetes. To pursue these research questions we have established long-term close collaborations both nationally (Swedish Winter Sports Research Centre, Östersund, Sweden) and internationally (Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany and the Broad Institute of Harvard and MIT, Boston, US).
Current funding (2015-)
Magnus Bergwalls stiftelse
The Crafoord Foundation
The Påhlsson Foundation
Avtal om läkares utbildning och forskning (ALF)
Selected recent papers
Su J.*, Ekman C.*, Oskolkov N., Lahti L., Ström K., Brazma A., Groop L., Rung J., Hansson O. “A novel atlas of gene expression in human skeletal muscle reveals molecular changes associated with aging”
2015, Skelet Muscle, (in press)
Ekman C., Elgzyri T., Ström K., Almgren P., Parikh H., Dekker Nitert M., Rönn T., Manderson Koivula F., Ling C., Tornberg Å.B., Wollmer P., Eriksson K.F., Groop L., Hansson O. “Less pronounced response to exercise in healthy relatives to type 2 diabetics compared to controls”
2015, J Appl Physiol, (in press)
Zhou Y., Park S.-Y., Su J., Bailey K., Ottosson-Laakso E., Shcherbina L., Oskolkov N., Zhang E., Thevenin T., Fadista J., Bennet H., Vikman P., Wierup N., Fex M., Rung J., Wollheim C., Nobrega M., Renström E., Groop L., Hansson O. “TCF7L2 is a master regulator of insulin production and processing”
2014, Hum Mol Genet, Dec 15;23(24):6419-31
Bozek K., Wei Y., Yan Z., Liu X., Xiong J., Sugimoto M., Tomita M., Pääbo S., Pieszek R., Sherwood C. C., Hof P. R., Ely J. J., Steinhauser D., Willmitzer L., Bangsbo J., Hansson O., Call J.*, Giavalisco P.*, Khaitovich P.* ”Exceptional evolutionary divergence of human muscle and brain metabolomes parallels human cognitive and physical uniqueness”
2014, PLoS Biol, May 27;12(5):
*Keildson S., *Fadista J., Ladenvall C., Hedman Å.K., Elgzyri T., Small K.S., Grundberg E., Nica A.C., Glass D., Richards J.B., Barrett A., Nisbet J., Zheng H., Rönn T., Ström K., Eriksson K., Prokopenko I., MAGIC consortium, DIAGRAM consortium, MuTHER consortium, Spector T.D., Dermitzakis E.T., Deloukas P., McCarthy M.I., Rung J., Groop L., Franks P.W., *Lindgren C.M., *Hansson O. “Skeletal Muscle Expression of Phosphofructokinase is Influenced by Genetic Variation and Associated with Insulin Sensitivity”
2014, Diabetes, Mar;63(3):1154-65
Claussnitzer M., Dankel S.N., Klocke B., Grallert H., Glunk V., Berulava T., Lee H., Oskolkov N., Fadista J., Ehlers K., Wahl S., Hoffmann C., Qian K., Rönn T., Riess L., Müller-Nurasyid M., Bretschneider N., Skurk T., Horsthemke B., DIAGRAM+ Consortium, Spieler D., Klingenspor M., Seifert M., Kern M.J., Mejhert N., Dahlman I., Hansson O., Hauck S.M., Blüher M., Arner P., Groop L., Illig T., Suhre K., HsuY.-H., Mellgren G., Hauner H., Laumen H. “Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms”
2014, Cell, Jan 16;156(1-2):343-58
Retrieved from Lund University's publications database
- Endogenous beta-cell CART regulates insulin secretion and transcription of beta-cell genes
- Glucose-induced Changes in Gene Expression in Human Pancreatic Islets - Causes or Consequences of Chronic Hyperglycemia
- Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness
- LoFtool : a gene intolerance score based on loss-of-function variants in 60 706 individuals
- No additional benefits of block- over evenly-distributed high-intensity interval training within a polarized microcycle
- Salt-inducible kinase 2 and -3 are downregulated in adipose tissue from obese or insulin-resistant individuals : implications for insulin signalling and glucose uptake in human adipocytes
- A novel atlas of gene expression in human skeletal muscle reveals molecular changes associated with aging.
- Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene
- Less pronounced response to exercise in healthy relatives to type 2 diabetics compared to controls.
- Myocardin Family Members Drive Formation of Caveolae.
- Photocoagulation of human retinal pigment epithelium in vitro: unravelling the effects on ARPE-19 by transcriptomics and proteomics.
- A Central Role for GRB10 in Regulation of Islet Function in Man.
- Exceptional evolutionary divergence of human muscle and brain metabolomes parallels human cognitive and physical uniqueness.
- Expression of Phosphofructokinase in Skeletal Muscle Is Influenced by Genetic Variation and Associated With Insulin Sensitivity
- Extensive changes in the transcriptional profile of human adipose tissue including genes involved in oxidative phosphorylation after a six months exercise intervention.
- Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism.
- Leveraging cross-species transcription factor binding site patterns: from diabetes risk Loci to disease mechanisms.
- TCF7L2 is a master regulator of insulin production and processing.
- A common variant upstream of the PAX6 gene influences islet function in man.
- A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
- A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets.
- First-Degree Relatives of Type 2 Diabetic Patients Have Reduced Expression of Genes Involved in Fatty Acid Metabolism in Skeletal Muscle.
- Impact of an Exercise Intervention on DNA Methylation in Skeletal Muscle From First-Degree Relatives of Patients With Type 2 Diabetes.
- Role of TCF7L2 risk variant and dietary fibre intake on incident type 2 diabetes.
- Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes.
- Survival of pancreatic beta cells is partly controlled by a TCF7L2-p53-p53INP1-dependent pathway.
- Telomere length in blood and skeletal muscle in relation to measures of glycaemia and insulinaemia.
- The Triglyceride Content in Skeletal Muscle Is Associated with Hepatic But Not Peripheral Insulin Resistance in Elderly Twins.
- Relation between cycling exercise capacity, fiber-type composition, and lower extremity muscle strength and muscle endurance.
- Running with regulation
- Survival of rat pancreatic islets is partly controlled by a TCF7L2-p53-p53INP1 dependent pathway
- The expression of myosin heavy chain (MHC) genes in human skeletal muscle is related to metabolic characteristics involved in the pathogenesis of type 2 diabetes.
- A mRNA marker for glycolytic muscle fibres may be used to determine fibre type composition in human skeletal muscle
- Molecular Function of TCF7L2: Consequences of TCF7L2 Splicing for Molecular Function and Risk for Type 2 Diabetes.
- Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes.
- Resistance to exercise-induced changes in the global DNA methylation pattern of skeletal muscle in individuals with a family history of type 2 diabetes
- TCF7L2-conferred apoptosis in pancreatic beta cells involves the p53 pathway
- Evaluation of chloride channel-3 as a potential target for TCF7L2-dependent impairment of insulin secretion
- Hormone-sensitive lipase (HSL) is also a retinyl ester hydrolase: evidence from mice lacking HSL.
- The impact of differential splicing of TCF7L2 on target gene expression in human islet of Langerhans
- Tissue-specific alternative splicing of TCF7L2
- Unique splicing pattern of the TCF7L2 gene in human pancreatic islets.
- Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle.
- Attainment of brown adipocyte features in white adipocytes of hormone-sensitive lipase null mice.
- Effect of exercise on gene transcript profiles in skeletal muscle of individuals with and without a family history of diabetes
- Hormone-sensitive lipase is necessary for normal mobilization of lipids during sub-maximal exercise.
- Proteomic studies in animal models of diabetes