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ludc webb

Nuno Dias

Adjunct professor

ludc webb

Validation of a New Method for 2D Fusion Imaging Registration in a System Prepared Only for 3D


  • Andreas Edsfeldt
  • Björn Sonesson
  • Helena Rosén
  • Marcelo H. Petri
  • Kiattisak Hongku
  • Timothy Resch
  • Nuno V. Dias

Summary, in English

Purpose: To validate a new 2D-3D registration method of fusion imaging during aortic repair in a system prepared only for 3D-3D registration and to compare radiation doses and accuracy. Materials and Methods: The study involved 189 patients, including 94 patients (median age 70 years; 85 men) who underwent abdominal endovascular aneurysm repair (EVAR) with 2D-3D fusion on an Artis zee imaging system and 95 EVAR patients (median age 70 years; 81 men) from a prior study who had 3D-3D registration done using cone beam computed tomography (CBCT). For the 2D-3D registration, an offline CBCT of the empty operating table was imported into the intraoperative dataset and superimposed on the preoperative computed tomography angiogram (CTA). Then 2 intraoperative single-frame 2D images of the skeleton were aligned with the patient’s skeleton on the preoperative CTA to complete the registration process. A digital subtraction angiogram was done to correct any misalignment of the aortic CTA volume. Values are given as the median [interquartile range (IQR) Q1, Q3]. Results: The 2D-3D registration had an accuracy of 4.0 mm (IQR 3.0, 5.0) after bone matching compared with the final correction with DSA (78% within 5 mm). By applying the 2D-3D protocol the radiation exposure (dose area product) from the registration of the fusion image was significantly reduced compared with the 3D-3D registration [1.12 Gy∙cm2 (IQR 0.41, 2.14) vs 43.4 Gy∙cm2 (IQR 37.1, 49.0), respectively; p<0.001). Conclusion: The new 2D-3D registration protocol based on 2 single-frame images avoids an intraoperative CBCT and can be used for fusion imaging registration in a system originally designed for 3D-3D only. This 2D-3D registration protocol is accurate and leads to a significant reduction in radiation exposure.


  • Cardiovascular Research - Translational Studies
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • Vascular Diseases - Clinical Research

Publishing year







Journal of Endovascular Therapy





Document type

Journal article


International Society of Endovascular Specialists


  • Radiology, Nuclear Medicine and Medical Imaging


  • computed tomography angiography
  • cone beam computed tomography
  • endovascular aneurysm repair
  • fusion imaging
  • procedure guidance
  • radiation exposure
  • registration protocol



Research group

  • Cardiovascular Research - Translational Studies
  • Vascular Diseases - Clinical Research


  • ISSN: 1526-6028