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Nils Wierup

Nils Wierup

Senior lecturer

Nils Wierup

Gastrointestinal dysfunction contributes to weight loss in Huntington's disease mice.

Author

  • Jorien m van der Burg
  • Annika Winqvist
  • N Ahmad Aziz
  • Marion L C Maat-Schieman
  • Raymund A C Roos
  • Gillian P Bates
  • Patrik Brundin
  • Maria Björkqvist
  • Nils Wierup

Summary, in English

Weight loss is the most important non-neurological complication of Huntington's disease (HD). It correlates with disease progression and affects the quality of life of HD patients, suggesting that it could be a valuable target for therapeutic intervention. The mechanism underlying weight loss in HD is unknown. Mutant huntingtin, the protein that causes the disease, is not only expressed in the brain, but also along the gastrointestinal (GI) tract. Here we demonstrate that the GI tract of HD mice is affected. At the anatomical level we observed loss of enteric neuropeptides, as well as decreased mucosal thickness and villus length. Exploring the functions of the GI system we found impaired gut motility, diarrhea, and malabsorption of food. The degree of malabsorption was inversely associated with body weight, suggesting that GI dysfunction plays an important role in weight loss in HD mice. In summary, these observations suggest that the GI tract is affected in HD mice and that GI dysfunction contributes to nutritional deficiencies and weight loss.

Department/s

  • Department of Experimental Medical Science
  • Paediatric Endocrinology
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • MultiPark: Multidisciplinary research focused on Parkinson´s disease

Publishing year

2011

Language

English

Pages

1-8

Publication/Series

Neurobiology of Disease

Volume

44

Document type

Journal article

Publisher

Elsevier

Topic

  • Neurosciences

Status

Published

Research group

  • Paediatric Endocrinology

ISBN/ISSN/Other

  • ISSN: 0969-9961