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Nils Wierup

Nils Wierup

Senior lecturer

Nils Wierup

Serotonin (5-HT) receptor 2b activation augments glucose-stimulated insulin secretion in human and mouse islets of Langerhans.

Author

  • Hedvig Bennet
  • Ines Mollet
  • Alexander Balhuizen
  • Anya Medina Benavente
  • Cecilia Nagorny
  • Annika Bagge
  • Joao Fadista
  • Emilia Ottosson Laakso
  • Petter Vikman
  • Marloes Dekker Nitert
  • Lena Eliasson
  • Nils Wierup
  • Isabella Artner
  • Malin Fex

Summary, in English

The Gq-coupled 5-hydroxytryptamine 2B (5-HT2B) receptor is known to regulate the proliferation of islet beta cells during pregnancy. However, the role of serotonin in the control of insulin release is still controversial. The aim of the present study was to explore the role of the 5-HT2B receptor in the regulation of insulin secretion in mouse and human islets, as well as in clonal INS-1(832/13) cells.

Department/s

  • Celiac Disease and Diabetes Unit
  • Diabetes - Islet Cell Exocytosis
  • Diabetes - Molecular Metabolism
  • Genomics, Diabetes and Endocrinology
  • Neuroendocrine Cell Biology
  • Stem Cell Center
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • StemTherapy: National Initiative on Stem Cells for Regenerative Therapy

Publishing year

2016-01-06

Language

English

Pages

744-754

Publication/Series

Diabetologia

Volume

59

Issue

4

Document type

Journal article

Publisher

Springer

Topic

  • Endocrinology and Diabetes

Status

Published

Research group

  • Celiac Disease and Diabetes Unit
  • Diabetes - Islet Cell Exocytosis
  • Diabetes - Molecular Metabolism
  • Genomics, Diabetes and Endocrinology
  • Neuroendocrine Cell Biology

ISBN/ISSN/Other

  • ISSN: 1432-0428