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Nils Wierup

Nils Wierup

Senior lecturer

Nils Wierup

Characterization of Gastric Mucosa Biopsies Reveals Alterations in Huntington's Disease.

Author

  • Andy Mccourt
  • Kirsty L O'Donovan
  • Eva Ekblad
  • Elin Sand
  • David Craufurd
  • Anne Rosser
  • David Sanders
  • Nicholas Stoy
  • Hugh Rickards
  • Nils Wierup
  • Gillian P Bates
  • Maria Björkqvist
  • Oliver Quarrell

Summary, in English

Weight loss is an important complication of Huntington's disease (HD), however the mechanism for weight loss in HD is not entirely understood. Mutant huntingtin is expressed in the gastrointestinal (GI) tract and, in HD mice, mutant huntingtin inclusions are found within the enteric nervous system along the GI tract. A reduction of neuropeptides, decreased mucosal thickness and villus length, as well as gut motility impairment, have also been shown in HD mice. We therefore set out to study gastric mucosa of patients with HD, looking for abnormalities of mucosal cells using immunohistochemistry. In order to investigate possible histological differences related to gastric acid production, we evaluated the cell density of acid producing parietal cells, as well as gastrin producing cells (the endocrine cell controlling parietal cell function). In addition, we looked at chief cells and somatostatin-containing cells. In gastric mucosa from HD subjects, compared to control subject biopsies, a reduced expression of gastrin (a marker of G cells) was found. This is in line with previous HD mouse studies showing reduction of GI tract neuropeptides.

Department/s

  • Biomarkers in Brain Disease
  • Neurogastroenterology
  • Neuroendocrine Cell Biology
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • MultiPark: Multidisciplinary research focused on Parkinson´s disease

Publishing year

2015

Language

English

Publication/Series

PLoS Currents

Volume

7

Document type

Journal article

Publisher

Public Library of Science

Topic

  • Gastroenterology and Hepatology

Status

Published

Research group

  • Biomarkers in Brain Disease
  • Neurogastroenterology
  • Neuroendocrine Cell Biology

ISBN/ISSN/Other

  • ISSN: 2157-3999