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Nils Wierup

Nils Wierup

Senior lecturer

Nils Wierup

N-cadherin is dispensable for pancreas development but required for beta-cell granule turnover.

Author

  • Jenny Johansson
  • Ulrikke Voss
  • Gokul Kesavan
  • Igor Kostetskii
  • Nils Wierup
  • Glenn L Radice
  • Henrik Semb

Summary, in English

The cadherin family of cell adhesion molecules mediates adhesive interactions that are required for the formation and maintenance of tissues. Previously, we demonstrated that N-cadherin, which is required for numerous morphogenetic processes, is expressed in the pancreatic epithelium at E9.5, but later becomes restricted to endocrine aggregates in mice. To study the role of N-cadherin during pancreas formation and function we generated a tissue-specific knockout of N-cadherin in the early pancreatic epithelium by inter-crossing N-cadherin-floxed mice with Pdx1Cre mice. Analysis of pancreas-specific ablation of N-cadherin demonstrates that N-cadherin is dispensable for pancreatic development, but required for beta-cell granule turnover. The number of insulin secretory granules is significantly reduced in N-cadherin-deficient beta-cells, and as a consequence insulin secretion is decreased.

Department/s

  • Stem Cell Center
  • Department of Experimental Medical Science
  • EXODIAB: Excellence of Diabetes Research in Sweden

Publishing year

2010

Language

English

Pages

374-381

Publication/Series

Genesis: The Journal of Genetics and Development

Volume

48

Issue

6

Document type

Journal article

Publisher

John Wiley and Sons

Topic

  • Cell and Molecular Biology

Status

Published

ISBN/ISSN/Other

  • ISSN: 1526-954X