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Nils Wierup

Nils Wierup

Senior lecturer

Nils Wierup

Glucose-dependent insulinotropic polypeptide lowers branched chain amino acids in hyperglycemic rats.

Author

  • Peter Spégel
  • Andreas Lindqvist
  • Monica Sandberg
  • Nils Wierup

Summary, in English

Hypersecretion of the incretin hormone glucose-dependent insulinotropic polypeptide (GIP) has been associated with obesity and glucose intolerance. This condition has been suggested to be linked to GIP resistance. Besides its insulinotropic effect, GIP also directly affects glucose uptake and lipid metabolism. This notwithstanding, effects of GIP on other circulating metabolites than glucose have not been thoroughly investigated. Here, we examined effects of infusion of various concentrations of GIP in normo- and hyperglycemic rats on serum metabolite profiles. We found that, despite a decrease in serum glucose levels (-26%, p<0.01), the serum metabolite profile was largely unaffected by GIP infusion in normoglycemic rats. Interestingly, levels of branched chain amino acids and the ketone body β-hydroxybutyrate were decreased by 21% (p<0.05) and 27% (p<0.001), respectively, in hyperglycemic rats infused with 60ng/ml GIP. Hence, our data suggest that GIP provokes a decrease in BCAA levels and ketone body production. Increased concentrations of these metabolites have been associated with obesity and T2D.

Department/s

  • Diabetes - Molecular Metabolism
  • Neuroendocrine Cell Biology
  • EXODIAB: Excellence of Diabetes Research in Sweden

Publishing year

2014

Language

English

Pages

11-16

Publication/Series

Regulatory Peptides

Volume

189

Document type

Journal article

Publisher

Elsevier

Topic

  • Cell and Molecular Biology

Status

Published

Research group

  • Diabetes - Molecular Metabolism
  • Neuroendocrine Cell Biology

ISBN/ISSN/Other

  • ISSN: 1873-1686