Nils Wierup

Type 2 diabetes candidate genes, including PAX5, cause impaired insulin secretion in human pancreatic islets

Karl Bacos, Alexander Perfilyev, Alexandros Karagiannopoulos, Elaine Cowan, Jones K Ofori, et al.
(2023) The Journal of clinical investigation, 133
Journal article

Editorial : Special issue novel aspects of islet peptides

Lena Eliasson, Nils Wierup
(2022) Peptides, 157
Journal article (comment)

In vivo drug discovery for increasing incretin-expressing cells identifies DYRK inhibitors that reinforce the enteroendocrine system

Lianhe Chu, Michishige Terasaki, Charlotte L. Mattsson, Romain Teinturier, Jérémie Charbord, et al.
(2022) Cell Chemical Biology, 29 p.5-1380
Journal article

Obesity-associated Blunted Subcutaneous Adipose Tissue Blood Flow After Meal Improves After Bariatric Surgery

Teemu Saari, Jukka Koffert, Henri Honka, Saila Kauhanen, Mueez U-Din, et al.
(2022) Journal of Clinical Endocrinology and Metabolism, 107 p.1930-1938
Journal article

Overexpressed beta cell CART increases insulin secretion in mouse models of insulin resistance and diabetes

Mia Abels, Matteo Riva, Liliya Shcherbina, Ann Helen Thorén Fischer, Elin Banke, et al.
(2022) Peptides, 151
Journal article

The role of CART in islet biology

Nils Wierup, Mia Abels, Liliya Shcherbina, Andreas Lindqvist
(2022) Peptides, 149
Journal article review

Postprandial triglyceride levels rather than fat distribution may reflect early signs of disturbed fat metabolism in Iraqi immigrants

Karin G. Stenkula, Lisa Esbjörnsson Klemendz, Claes Fryklund, Nils Wierup, Wathik Alsalim, et al.
(2022) Lipids in Health and Disease, 21 p.1-12
Journal article

Lessons from single-cell RNA sequencing of human islets

Mtakai Ngara, Nils Wierup
(2022) Diabetologia, 65 p.1241-1250
Journal article review

Data-driven subgroups of type 2 diabetes, metabolic response, and renal risk profile after bariatric surgery : a retrospective cohort study

Violeta Raverdy, Ricardo V. Cohen, Robert Caiazzo, Helene Verkindt, Tarissa Beatrice Zanata Petry, et al.
(2022) The Lancet Diabetes and Endocrinology, 10 p.167-176
Journal article

Islet Gene View-a tool to facilitate islet research

Olof Asplund, Petter Storm, Vikash Chandra, Gad Hatem, Emilia Ottosson-Laakso, et al.
(2022) Life Science Alliance, 5
Journal article

SCRT1 is a novel beta cell transcription factor with insulin regulatory properties

S. Chriett, A. Lindqvist, L. Shcherbina, A. Edlund, M. Abels, et al.
(2021) Molecular and Cellular Endocrinology, 521
Journal article

GK-rats respond to gastric bypass surgery with improved glycemia despite unaffected insulin secretion and beta cell mass

Michael G. Miskelly, Liliya Shcherbina, Ann Helen Thorén Fischer, Mia Abels, Andreas Lindqvist, et al.
(2021) Peptides, 136
Journal article

Metabolic Effects of Gastric Bypass Surgery : Is It All About Calories?

Katharina Herzog, Johan Berggren, Mahmoud Al Majdoub, Claudia Balderas Arroyo, Andreas Lindqvist, et al.
(2020) Diabetes, 69 p.2027-2035
Journal article

Lack of melatonin type 1 receptor results in dysregulated alpha cell function and metabolism

CL Lyons, A Hamilton, D Grajales, L Shcherbina, A Lindqvist, et al.
(2020) Diabetologia, 63 p.231-231
Conference paper: abstract

Ghrelin suppresses insulin secretion in human islets and type 2 diabetes patients have diminished islet ghrelin cell number and lower plasma ghrelin levels

A Lindqvist, L Shcherbina, R B Prasad, M G Miskelly, M Abels, et al.
(2020) Molecular and Cellular Endocrinology, 511
Journal article

No direct effect of SGLT2 activity on glucagon secretion

Rune E. Kuhre, Seyed M. Ghiasi, Alice E. Adriaenssens, Nicolai J. Wewer Albrechtsen, Daniel B. Andersen, et al.
(2019) Diabetologia, 62 p.1011-1023
Journal article

Defective exocytosis and processing of insulin in a cystic fibrosis mouse model

Anna Edlund, Mohammad Barghouth, Michael Huhn, Mia Abels, Jonathan Esguerra, et al.
(2019) Journal of Endocrinology, 241 p.45-57
Journal article

N¹-methylnicotinamide is a signalling molecule produced in skeletal muscle coordinating energy metabolism

Kristoffer Ström, David Morales-Alamo, Filip Ottosson, Anna Edlund, Line Hjort, et al.
(2018) Scientific Reports, 8
Journal article

Intestinal CART is a regulator of GIP and GLP-1 secretion and expression

L. Shcherbina, A. Lindqvist, A. H. Thorén Fischer, E. Ahlqvist, E. Zhang, et al.
(2018) Molecular and Cellular Endocrinology, 476 p.8-16
Journal article

Effects of GIP on regional blood flow during normoglycemia and hyperglycemia in anesthetized rats

Xiang Gao, Andreas Lindqvist, Monica Sandberg, Leif Groop, Nils Wierup, et al.
(2018) Physiological Reports, 6
Journal article

Glutamine-elicited secretion of glucagon-like peptide 1 is governed by an activated glutamate dehydrogenase

Lotta E. Andersson, Liliya Shcherbina, Mahmoud Al-Majdoub, Neelanjan Vishnu, Claudia Balderas Arroyo, et al.
(2018) Diabetes, 67 p.372-384
Journal article

Early deficits in insulin secretion, beta cell mass and islet blood perfusion precede onset of autoimmune type 1 diabetes in BioBreeding rats

Anya Medina, Saba Parween, Sara Ullsten, Neelanjan Vishnu, Yuk Ting Siu, et al.
(2018) Diabetologia, 61 p.896-905
Journal article

Liver blood dynamics after bariatric surgery : The effects of mixed-meal test and incretin infusions

Henri Honka, Jukka Koffert, Saila Kauhanen, Nobuyuki Kudomi, Saija Hurme, et al.
(2018) Endocrine Connections, 7 p.888-896
Journal article

Experiments suggesting extra-digestive effects of enteral pancreatic amylase and its peptides on glucose homeostasis in a pig model

Stefan G. Pierzynowski, Kateryna Goncharova, Peter C Gregory, Björn Weström, Sergiy E. Podpryatov, et al.
(2017) Scientific Reports, 7
Journal article

Ghrelin rescues skeletal muscle catabolic profile in the R6/2 mouse model of Huntington's disease

Marie Sjögren, Ana I. Duarte, Andrew C McCourt, Liliya Shcherbina, Nils Wierup, et al.
(2017) Scientific Reports, 7
Journal article

Genetic determinants of circulating GIP and GLP-1 concentrations

Peter Almgren, Andreas Lindqvist, Ulrika Krus, Liisa H. Hakaste, Emilia Ottosson Laakso, et al.
(2017) JCI Insight, 2
Journal article

Parent-of-origin effects on gene expression in trios with type 2 diabetic offspring

Rashmi Prasad, Györgyi Kovacs, Andreas Lindqvist, Isabella Artner, Anna Lessmark, et al.
(2017)
Poster

Mitochondrial transcription factor B2 is essential for mitochondrial and cellular function in pancreatic β-cells

Lisa M. Nicholas, Bérengère Valtat, Anya Medina Benavente, Lotta Andersson, Mia Abels, et al.
(2017) Molecular Metabolism, 6 p.651-663
Journal article

Nuclear import of glucokinase in pancreatic beta-cells is mediated by a nuclear localization signal and modulated by SUMOylation

Bente Berg Johansson, Karianne Fjeld, Marie Holm Solheim, Jun Shirakawa, Enming Zhang, et al.
(2017) Molecular and Cellular Endocrinology, 454 p.146-157
Journal article

Ghrelin is a regulator of glucagon-like peptide 1 secretion and transcription in mice

Andreas Lindqvist, Liliya Shcherbina, Ann-Helen Thorén Fischer, Nils Wierup
(2017) Frontiers in Endocrinology, 8
Journal article

Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes

Annika S. Axelsson, Emily Tubbs, Brig Mecham, Shaji Chacko, Hannah A. Nenonen, et al.
(2017) Science Translational Medicine, 9
Journal article

Gastric bypass in the pig increases GIP levels and decreases active GLP-1 levels

Andreas Lindqvist, Mikael Ekelund, Stefan Pierzynowski, Leif Groop, Jan Hedenbro, et al.
(2017) Peptides, 90 p.78-82
Journal article

Bariatric surgery enhances splanchnic vascular responses in patients with type 2 diabetes

Henri Honka, Jukka Koffert, Saila Kauhanen, Jarmo Teuho, Saija Hurme, et al.
(2017) Diabetes, 66 p.880-885
Journal article

CFTR is involved in the regulation of glucagon secretion in human and rodent alpha cells

Anna Edlund, Morten Gram Pedersen, Andreas Lindqvist, Nils Wierup, Malin Flodström-Tullberg, et al.
(2017) Scientific Reports, 7 p.1-12
Journal article

The impact of Roux-en-Y gastric bypass surgery on normal metabolism in a porcine model

Andreas Lindqvist, Mikael Ekelund, Eliana Garcia-Vaz, Marcus Ståhlman, Stefan Pierzynowski, et al.
(2017) PLoS ONE, 12
Journal article

Endogenous beta-cell CART regulates insulin secretion and transcription of beta-cell genes

L Shcherbina, A Edlund, J L S Esguerra, M Abels, Y Zhou, et al.
(2017) Molecular and Cellular Endocrinology, 447 p.52-60
Journal article

Roux-en-Y gastric bypass versus calorie restriction: support for surgery as the direct contributor to aloncltered responses of insulin and incretins to a mixed meal

JOHAN BERGGREN, Andreas Lindqvist, Jan Hedenbro, Leif Groop, Nils Wierup
(2017) Surgery for Obesity and Related Diseases, 13 p.234-242
Journal article

The density of parasympathetic axons is reduced in the exocrine pancreas of individuals recently diagnosed with type 1 diabetes

Marcus Lundberg, Andreas Lindqvist, Nils Wierup, Lars Krogvold, Knut Dahl-Jørgensen, et al.
(2017) PLoS ONE, 12
Journal article

Effects of meal and incretins in the regulation of splanchnic blood flow

Jukka Koffert, Henri Honka, Jarmo Teuho, Saila Kauhanen, Saija Hurme, et al.
(2017) Endocrine Connections, 6 p.179-187
Journal article

CART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion

Mia Abels, Matteo Riva, Hedvig Bennet, Emma Ahlqvist, Oleg Dyachok, et al.
(2016) Diabetologia, 59 p.1928-1937
Journal article

Increased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes

Tiinamaija Tuomi, Cecilia L F Nagorny, Pratibha Singh, Hedvig Bennet, Qian Yu, et al.
(2016) Cell Metabolism, 23 p.1067-1077
Journal article

HMGB1 binds to the rs7903146 locus in TCF7L2 in human pancreatic islets.

Yuedan Zhou, Nikolay Oskolkov, Liliya Shcherbina, Joyce Ratti, Kian-Hong Kock, et al.
(2016) Molecular and Cellular Endocrinology, 430 p.138-145
Journal article

Serotonin (5-HT) receptor 2b activation augments glucose-stimulated insulin secretion in human and mouse islets of Langerhans.

Hedvig Bennet, Ines Mollet, Alexander Balhuizen, Anya Medina Benavente, Cecilia Nagorny, et al.
(2016) Diabetologia, 59 p.744-754
Journal article

Decreased insulin secretion and glucose clearance in exocrine pancreas-insufficient pigs.

Liudmyla Lozinska, Björn Weström, Olena Prykhodko, Andreas Lindqvist, Nils Wierup, et al.
(2016) Experimental Physiology, 101 p.100-112
Journal article

L24 The effect of ghrelin administration in the R6/2 mouse model of Huntington’s disease

Marie Sjögren, Ana Duarte, Andrew C Mccourt, Liliya Shcherbina, Ann-Helen Thorén Fischer, et al.
(2016) Journal of Neurology, Neurosurgery and Psychiatry, 87
Conference paper: abstract

Characterization of Gastric Mucosa Biopsies Reveals Alterations in Huntington's Disease.

Andy Mccourt, Kirsty L O'Donovan, Eva Ekblad, Elin Sand, David Craufurd, et al.
(2015) PLoS Currents, 7
Journal article

Altered serotonin (5-HT) 1D and 2A receptor expression may contribute to defective insulin and glucagon secretion in human type 2 diabetes.

Hedvig Bennet, Alexander Balhuizen, Anya Medina Benavente, Marloes Dekker Nitert, Emilia Ottosson Laakso, et al.
(2015) Peptides, 71 p.113-120
Journal article

Short- and Long-Term Hormonal and Metabolic Consequences of Reversing Gastric Bypass to Normal Anatomy in a Type 2 Diabetes Patient.

Nils Wierup, Andreas Lindqvist, Peter Spégel, Leif Groop, Jan Hedenbro, et al.
(2015) Obesity Surgery, 25 p.180-185
Journal article

Mucosal glucagon-like peptide-1 and gastric inhibitory polypeptide cell numbers in the super-obese human foregut after gastric bypass.

Bent J Nergård, Andreas Lindqvist, Hjörtur G Gislason, Leif Groop, Mikael Ekelund, et al.
(2015) Surgery for Obesity and Related Diseases, 11 p.1237-1246
Journal article

GASTRIC BYPASS SURGERY HAS GREATER EFFECT THAN CALORIE RESTRICTION ON INCRETIN RELEASE AND INSULIN SECRETION ALREADY ON POSTOP. DAY 1

Johan Berggren, Andreas Lindqvist, Leif Groop, Jan Hedenbro, Nils Wierup
(2015) Obesity Surgery, 25 p.85-85
Conference paper: abstract

A Central Role for GRB10 in Regulation of Islet Function in Man.

Inga Prokopenko, Wenny Poon, Reedik Mägi, Rashmi Prasad, S Albert Salehi, et al.
(2014) PLoS Genetics, 10
Journal article

The islet ghrelin cell.

Nils Wierup, Frank Sundler, Scott Heller
(2014) Journal of Molecular Endocrinology, 52 p.35-49
Journal article review

TCF7L2 is a master regulator of insulin production and processing.

Yuedan Zhou, Soo-Young Park, Jing Su, Kathleen Bailey, Emilia Ottosson Laakso, et al.
(2014) Human Molecular Genetics, 23 p.6419-6431
Journal article

Loss of TFB1M results in mitochondrial dysfunction that leads to impaired insulin secretion and diabetes.

Vladimir Sharoyko, Mia Abels, Jiangming Sun, Lisa Nicholas, Ines Mollet, et al.
(2014) Human Molecular Genetics, 23 p.5733-5749
Journal article

Glucose-dependent insulinotropic polypeptide lowers branched chain amino acids in hyperglycemic rats.

Peter Spégel, Andreas Lindqvist, Monica Sandberg, Nils Wierup
(2014) Regulatory Peptides, 189 p.11-16
Journal article

Gastric bypass improves ss-cell function and increases β-cell mass in a porcine model.

Andreas Lindqvist, Peter Spégel, Mikael Ekelund, Eliana Garcia Vaz, Stefan Pierzynowski, et al.
(2014) Diabetes, 63 p.1665-1671
Journal article

A link between GIP and osteopontin in adipose tissue and insulin resistance.

Emma Ahlqvist, Peter Osmark, Tiina Kuulasmaa, Kasper Pilgaard, Bilal Omar, et al.
(2013) Diabetes, 62 p.2088-2094
Journal article

Cocaine- and Amphetamine-regulated Transcript (CART) Protects Beta Cells against Glucotoxicity and Increases Cell Proliferation

Ramasri Sathanoori, Björn Olde, David Erlinge, Olga Göransson, Nils Wierup
(2013) Journal of Biological Chemistry, 288 p.3208-3218
Journal article

Expression profiling of cell cycle genes in human pancreatic islets with and without type 2 diabetes.

Jalal Taneera, Joao Fadista, Emma Ahlqvist, Mengze Zhang, Nils Wierup, et al.
(2013) Molecular and Cellular Endocrinology, 375 p.35-42
Journal article

Effects of ingestion routes on hormonal and metabolic profiles in gastric-bypassed humans

Andreas Lindqvist, Mikael Ekelund, Hindrik Mulder, Peter Spégel, Leif Groop, et al.
(2013) Journal of Clinical Endocrinology and Metabolism, 98 p.856-861
Journal article

Cocaine- and amphetamine-regulated transcript is expressed in adipocytes and regulate lipid- and glucose homeostasis.

Elin Banke, Matteo Riva, Liliya Shcherbina, Nils Wierup, Eva Degerman
(2013) Regulatory Peptides, 182 p.35-40
Journal article

Autoimmunity against INS-IGF2 expressed in human pancreatic islets.

Norio Kanatsuna, Jalal Taneera, Fariba Vaziri Sani, Nils Wierup, Helena Larsson, et al.
(2013) Journal of Biological Chemistry, 288 p.29013-29023
Journal article

Impact of an Exercise Intervention on DNA Methylation in Skeletal Muscle From First-Degree Relatives of Patients With Type 2 Diabetes.

Marloes Dekker Nitert, Tasnim Dayeh, Peter Volkov, Targ Elgzyri, Elin Hall, et al.
(2012) Diabetes
Journal article

Expression of Cocaine- and Amphetamine-Regulated Transcript Is Associated with Worse Survival in Small Bowel Carcinoid Tumors

Kalle Landerholm, Liliya Shcherbina, Sture E. Falkmer, Johannes Jarhult, Nils Wierup
(2012) Clinical Cancer Research, 18 p.3668-3676
Journal article

A Major Lineage of Enteroendocrine Cells Coexpress CCK, Secretin, GIP, GLP-1, PYY, and Neurotensin but Not Somatostatin.

Kristoffer L Egerod, Maja S Engelstoft, Kaare V Grunddal, Mark K Nøhr, Anna Secher, et al.
(2012) Endocrinology
Journal article

Nesfatin-1 stimulates glucagon and insulin secretion and beta cell NUCB2 is reduced in human type 2 diabetic subjects.

Matteo Riva, Marloes Dekker Nitert, Ulrikke Voss, Ramasri Sathanoori, Andreas Lindqvist, et al.
(2011) Cell and Tissue Research, 346 p.393-405
Journal article

Cocaine- and Amphetamine-Regulated Transcript in Neuroendocrine Tumors

Kalle Landerholm, Sture Falkmer, Johannes Jarhult, Frank Sundler, Nils Wierup
(2011) Neuroendocrinology, 94 p.228-236
Journal article

beta-Cell Specific Overexpression of GPR39 Protects against Streptozotocin-Induced Hyperglycemia

Kristoffer L. Egerod, Chunyu Jin, Pia Steen Petersen, Nils Wierup, Frank Sundler, et al.
(2011) International Journal of Endocrinology
Journal article

Distribution of melatonin receptors in murine pancreatic islets.

Cecilia Nagorny, Ramasri Sathanoori, Ulrikke Voss, Hindrik Mulder, Nils Wierup
(2011) Journal of Pineal Research, 50 p.412-417
Journal article

Gastrointestinal dysfunction contributes to weight loss in Huntington's disease mice.

Jorien m van der Burg, Annika Winqvist, N Ahmad Aziz, Marion L C Maat-Schieman, Raymund A C Roos, et al.
(2011) Neurobiology of Disease, 44 p.1-8
Journal article

Biomechanical properties and innervation of the female caveolin-1-deficient detrusor.

Mardjaneh Karbalaei Sadegh, Mari Ekman, Catarina Rippe, Frank Sundler, Nils Wierup, et al.
(2011) British Journal of Pharmacology, Dec p.1156-1170
Journal article

Evidence for Presence and Functional Effects of Kv1.1 Channels in beta-Cells: General Survey and Results from mceph/mceph Mice

Zuheng Ma, Catharina Lavebratt, Malin Almgren, Neil Portwood, Lars E. Forsberg, et al.
(2011) PLoS ONE, 6
Journal article

Pleiotropic Effects of GIP on Islet Function Involve Osteopontin

Valeriya Lyssenko, Lena Eliasson, Olga Kotova, Kasper Pilgaard, Nils Wierup, et al.
(2011) Diabetes, 60 p.2424-2433
Journal article

CART is overexpressed in beta cells of diabetic mice to improve insulin secretion

Matteo Riva, Nils Wierup
(2010) Diabetologia, 53 p.546-546
Conference paper: abstract

Covariation of plasma ghrelin and motilin in irritable bowel syndrome.

Kristina Sjölund, Rolf Ekman, Nils Wierup
(2010) Peptides, 31 p.1109-1112
Journal article

Metabolic effects of whole grain wheat and whole grain rye in the C57BL/6J mouse.

Ulrika Axling, Liza Rosén, Elin Östman, Kristoffer Ström, Nils Wierup, et al.
(2010) Nutrition, 26 p.230-239
Journal article

A low glycaemic diet improves oral glucose tolerance but has no effect on β-cell function in C57BL/6J mice.

Ulrika Axling, Liza Rosén, Nils Wierup, Elin Östman, Inger Björck, et al.
(2010) Diabetes, Obesity and Metabolism, 12 p.976-982
Journal article

CART is upregulated in islets of type 2 diabetic patients, stimulates insulin secretion, inhibits glucagon secretion and protects against beta cell death

Ramasri Sathanoori, Ulrikke Voss, Matteo Riva, Maria Sörhede Winzell, Bo Ahrén, et al.
(2010) Diabetologia, 53 p.95-95
Conference paper: abstract

Increased beta-cell volume in mice fed a high-fat diet A dynamic study over 12 months

Jonatan Ahren, Bo Ahrén, Nils Wierup
(2010) Islets, 2 p.353-356
Journal article

Pancreatic islets of melatonin receptor knock-out mice

Cecilia Nagorny, Ulrikke Voss, Hedvig Bennet, Jelena Stamenkovic, Ramasri Sathanoori, et al.
(2010) Diabetologia, 53 p.294-294
Conference paper: abstract

Nesfatin-1 stimulates insulin secretion, inhibits glucagon secretion and is expressed in human and rodent beta cells

Ulrikke Voss, Matteo Riva, Marloes Dekker Nitert, Charlotte Ling, Anders Lindqvist, et al.
(2010) Diabetologia, 53 p.548-548
Conference paper: abstract

Stimulation of 5-HT1a receptor decreased insulin secretion in islets of Langerhans from mice and humans

Hedvig Bennet, Cecilia Nagorny, Nils Wierup, Marloes Dekker Nitert, Åke Lernmark, et al.
(2010) Diabetologia, 53 p.547-547
Conference paper: abstract

First Report on Metastasizing Small Bowel Carcinoids in First-Degree Relatives in Three Generations

Johannes Jarhult, Kalle Landerholm, Sture Falkmer, Magnus Nordenskjold, Frank Sundler, et al.
(2010) Neuroendocrinology, 91 p.318-323
Journal article

Growth arrest specific protein 6 (gas6) and its receptors expression and signalling in beta cells

Vladimir Sharoyko, Thomas Köck, Carl Ekman, Nils Wierup, Frank Sundler, et al.
(2010) Diabetologia, 53 p.530-530
Conference paper: abstract

Apelin is expressed in human and rodent islets and regulates insulin secretion

Camilla Ringstrom, Marloes Dekker Nitert, Hedvig Bennet, Malin Fex, Philippe Valet, et al.
(2010) Regulatory Peptides, 164 p.27-27
Conference paper: abstract

Cocaine- and amphetamine-regulated transcript (CART) is upregulated in islets of type-2 diabetic patients to stimulate insulin secretion, inhibit glucagon secretion and protect against beta cell death

Ramasri Sathanoori, Ulrikke Voss, Matteo Riva, Maria Sörhede Winzell, Bo Ahrén, et al.
(2010) Regulatory Peptides, 164 p.45-45
Conference paper: abstract

N-cadherin is dispensable for pancreas development but required for beta-cell granule turnover.

Jenny Johansson, Ulrikke Voss, Gokul Kesavan, Igor Kostetskii, Nils Wierup, et al.
(2010) Genesis: The Journal of Genetics and Development, 48 p.374-381
Journal article

Increased β-cell volume in mice fed a high-fat diet: A dynamic study over 12 months.

Jonatan Ahrén, Bo Ahrén, Nils Wierup
(2010) Islets, 2 p.12-15
Journal article

Apelin is a novel islet peptide.

Camilla Ringström, Marloes Dekker Nitert, Hedvig Bennet, Malin Fex, Philippe Valet, et al.
(2010) Regulatory Peptides, 162 p.44-51
Journal article

Phosphodiesterase 3B is localized in caveolae and smooth ER in mouse hepatocytes and is important in the regulation of glucose and lipid metabolism.

Karin Berger, Rebecka Lindh, Nils Wierup, Emilia Zmuda-Trzebiatowska, Andreas Lindqvist, et al.
(2009) PLoS ONE, 4
Journal article

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion.

Valeriya Lyssenko, Cecilia Nagorny, Michael R Erdos, Nils Wierup, Anna Jonsson, et al.
(2009) Nature Genetics, 41 p.82-88
Journal article

A beta cell-specific knockout of hormone-sensitive lipase in mice results in hyperglycaemia and disruption of exocytosis.

Malin Fex, G Haemmerle, Nils Wierup, Marloes Dekker Nitert, M Rehn, et al.
(2009) Diabetologia, 52 p.271-280
Journal article

Perilipin is present in islets of Langerhans and protects against lipotoxicity when overexpressed in the beta-cell line INS-1.

Jörgen Borg, Cecilia Klint, Nils Wierup, Kristoffer Ström, Sara Larsson, et al.
(2009) Endocrinology, 150 p.3049-3057
Journal article

Protein GAS6 and its receptor Axl are expressed and operate in pancreatic beta cells

Vladimir Sharoyko, Carl Ekman, Nils Wierup, Frank Sundler, Björn Dahlbäck, et al.
(2009) Diabetologia, 52 p.448-448
Conference paper: abstract

G Protein-Coupled Receptor 39 Deficiency Is Associated with Pancreatic Islet Dysfunction

Birgitte Holst, Kristoffer L. Egerod, Chunyu Jin, Pia Steen Petersen, Mette Viberg Ostergaard, et al.
(2009) Endocrinology, 150 p.2577-2585
Journal article

Long-term nicotine exposure causes increased concentrations of trypsinogens and amylase in pancreatic extracts in the rat.

Björn Lindkvist, Nils Wierup, Frank Sundler, Anders Borgström
(2008) Pancreas, 37 p.288-294
Journal article

Islet beta-cell area and hormone expression are unaltered in Huntington's disease.

Karl Bacos, Maria Björkqvist, Åsa Petersén, Lena Luts, Marion Maat-Schieman, et al.
(2008) Histochemistry and Cell Biology, 129 p.623-629
Journal article

Lack of cholesterol mobilization in islets of hormone-sensitive lipase deficient mice impairs insulin secretion.

Sara Larsson, Nils Wierup, Frank Sundler, Lena Eliasson, Cecilia Holm
(2008) Biochemical and Biophysical Research Communications, 376 p.558-562
Journal article

Increased metabolism in the R6/2 mouse model of Huntington's disease.

Jorien m van der Burg, Karl Bacos, Nigel I Wood, Andreas Lindqvist, Nils Wierup, et al.
(2008) Neurobiology of Disease, 29 p.41-51
Journal article

Gastric ghrelin cell development is hampered and plasma ghrelin is reduced by delayed weaning in rats

Frida Fåk, Lennart Friis-Hansen, Björn Weström, Nils Wierup
(2007) Journal of Endocrinology, 192 p.345-352
Journal article

DPP-4 inhibition improves glucose tolerance and increases insulin and GLP-1 responses to gastric glucose in association with normalized islet topography in mice with beta-cell-specific overexpression of human islet amyloid polypeptide.

Bo Ahrén, Maria Sorhede Winzell, Nils Wierup, Frank Sundler, Bryan Burkey, et al.
(2007) Regulatory Peptides, 143 p.97-103
Journal article

Glucagon receptor antagonism improves islet function in mice with insulin resistance induced by a high-fat diet.

Maria Sörhede Winzell, C Brand, Nils Wierup, U Sidelmann, Frank Sundler, et al.
(2007) Diabetologia, 50 p.1453-1462
Journal article

CART-peptide immunoreactivity in enteric nerves in patients with Hirschsprung's disease

Anna Gunnarsdottir, Nils Wierup, Lars Torsten Larsson, M. J. Kuhar, Eva Ekblad
(2007) European Journal of Pediatric Surgery, 17 p.184-189
Journal article

Rat insulin promoter 2-Cre recombinase mice bred onto a pure C57BL/6J background exhibit unaltered glucose tolerance

Malin Fex, Nils Wierup, Marloes Dekker Nitert, Michael Ristow, Hindrik Mulder
(2007) Journal of Endocrinology, 194 p.551-555
Journal article

beta-cell PDE3B regulates Ca(2+)-stimulated exocytosis of insulin.

Helena Jones, Nils Wierup, Jenny Vikman, Vincent C Manganiello, Eva Degerman, et al.
(2007) Cellular Signalling, 19 p.1505-1513
Journal article

Characterisation of CART-containing neurons and cells in the porcine pancreas, gastro-intestinal tract, adrenal and thyroid glands.

Nils Wierup, Anna Gunnarsdottir, Eva Ekblad, Frank Sundler
(2007) BMC Neuroscience, 8
Journal article

Ghrelin and motilin are cosecreted from a prominent endocrine cell population in the small intestine

Nils Wierup, Maria Björkqvist, Björn Weström, Stefan Pierzynowski, Frank Sundler, et al.
(2007) Journal of Clinical Endocrinology and Metabolism, 92 p.3573-3581
Journal article

Enhanced mitochondrial metabolism may account for the adaptation to insulin resistance in islets from C57BL/6J mice fed a high-fat diet.

Malin Fex, Marloes Dekker Nitert, Nils Wierup, Frank Sundler, Charlotte Ling, et al.
(2007) Diabetologia, 50 p.74-83
Journal article

Capsaicin-sensitive sensory fibers in the islets of Langerhans contribute to defective insulin secretion in Zucker diabetic rat, an animal model for some aspects of human type 2 diabetes

Dorte X. Gram, Bo Ahrén, Istvan Nagy, Uffe B. Olsen, Christian L. Brand, et al.
(2007) European Journal of Neuroscience, 25 p.213-223
Journal article

A Paleolithic diet confers higher insulin sensitivity, lower C-reactive protein and lower blood pressure than a cereal-based diet in domestic pigs.

Tommy Jönsson, Bo Ahrén, Giovanni Pacini, Frank Sundler, Nils Wierup, et al.
(2006) Nutrition & Metabolism, 3
Journal article

CART is a novel islet regulatory peptide.

Nils Wierup, Frank Sundler
(2006) Peptides, 27 p.2031-2036
Journal article review

Early and rapid development of insulin resistance, islet dysfunction and glucose intolerance after high-fat feeding in mice overexpressing phosphodiesterase 3B.

Helena Jones, Linda Härndahl, Nils Wierup, Emilia Zmuda-Trzebiatowska, Fredrik Svennelid, et al.
(2006) Journal of Endocrinology, 189 p.629-641
Journal article

Inflammatory response in white adipose tissue in the non-obese hormone-sensitive lipase null mouse model.

Ola Hansson, Kristoffer Ström, Nuray Güner, Nils Wierup, Frank Sundler, et al.
(2006) Journal of Proteome Research, 5 p.1701-1710
Journal article

Neuropeptides and the regulation of islet function.

Bo Ahrén, Nils Wierup, Frank Sundler
(2006) Diabetes, 55 p.98-107
Journal article

CART Regulates Islet Hormone Secretion and Is Expressed in the {beta}-Cells of Type 2 Diabetic Rats.

Nils Wierup, Maria Björkqvist, Michael J Kuhar, Hindrik Mulder, Frank Sundler
(2006) Diabetes, 55 p.305-311
Journal article

The R6/2 transgenic mouse model of Huntington's disease develops diabetes due to deficient {beta}-cell mass and exocytosis.

Maria Björkqvist, Malin Fex, Erik Renström, Nils Wierup, Åsa Petersén, et al.
(2005) Human Molecular Genetics, 14 p.565-574
Journal article

Orexin loss in Huntington's disease.

Åsa Petersén, Joana Gil, Marion L C Maat-Schieman, Maria Björkqvist, Heikki Tanila, et al.
(2005) Human Molecular Genetics, 14 p.39-47
Journal article

Antral G-cell in gastrin and gastrin-cholecystokinin knockout animals

L Friis-Hansen, Nils Wierup, J F Rehfeld, Frank Sundler
(2005) Cell and Tissue Research, 321 p.141-146
Journal article

CART knock out mice have impaired insulin secretion and glucose intolerance, altered beta cell morphology and increased body weight

Nils Wierup, W.G. Richards, A.W. Bannon, M.J. Kuhar, Bo Ahrén, et al.
(2005) Regulatory Peptides, 129 p.203-211
Journal article

Ghrelin and CART. Two new islet peptides. Expression, regulation and function.

Nils Wierup
(2005) Faculty of Medicine Doctoral Dissertation Series, 2005:55
Dissertation

Reduced ghrelin, IAPP and PYY expression in the stomach of gastrin-cholecystokinin knockout mice.

Lennart Friis-Hansen, Nils Wierup, Jens F Rehfeld, Frank Sundler
(2005) Endocrinology, 146 p.4464-4471
Journal article

Ultrastructure of islet ghrelin cells in the human fetus.

Nils Wierup, Frank Sundler
(2005) Cell and Tissue Research, 319 p.423-428
Journal article

Ghrelin Is Expressed in a Novel Endocrine Cell Type in Developing Rat Islets and Inhibits Insulin Secretion from INS-1 (832/13) Cells.

Nils Wierup, S Yang, R J McEvilly, Hindrik Mulder, Frank Sundler
(2004) Journal of Histochemistry and Cytochemistry, 52 p.301-310
Journal article

Loss-of-Function Mutation of the Galanin Gene is Associated with Perturbed Islet Function in Mice.

Bo Ahrén, Giovanni Pacini, David Wynick, Nils Wierup, Frank Sundler
(2004) Endocrinology, 145 p.3190-3196
Journal article

Cocaine- and Amphetamine-regulated Transcript (CART) Is Expressed in Several Islet Cell Types During Rat Development.

Nils Wierup, M Kuhar, Bengt-Olof Nilsson, Hindrik Mulder, Eva Ekblad, et al.
(2004) Journal of Histochemistry and Cytochemistry, 52 p.169-177
Journal article

Beta-cell-targeted overexpression of phosphodiesterase 3B in mice causes impaired insulin secretion, glucose intolerance and deranged glucose morphology.

Linda Härndahl, Nils Wierup, Sven Enerbäck, Hindrik Mulder, Vincent C Manganiello, et al.
(2004) Journal of Biological Chemistry, 279 p.15214-15222
Journal article

Nils Wierup

Publications