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A novel atlas of gene expression in human skeletal muscle reveals molecular changes associated with aging.

Author:
  • Jing Su
  • Carl Ekman
  • Nikolay Oskolkov
  • Leo Lahti
  • Kristoffer Ström
  • Alvis Brazma
  • Leif Groop
  • Johan Rung
  • Ola Hansson
Publishing year: 2015
Language: English
Publication/Series: Skeletal Muscle
Volume: 5
Document type: Journal article
Publisher: BioMed Central

Abstract english

Although high-throughput studies of gene expression have generated large amounts of data, most of which is freely available in public archives, the use of this valuable resource is limited by computational complications and non-homogenous annotation. To address these issues, we have performed a complete re-annotation of public microarray data from human skeletal muscle biopsies and constructed a muscle expression compendium consisting of nearly 3000 samples. The created muscle compendium is a publicly available resource including all curated annotation. Using this data set, we aimed to elucidate the molecular mechanism of muscle aging and to describe how physical exercise may alleviate negative physiological effects.

Keywords

  • Medical Genetics

Other

Published
  • Diabetes and Endocrinology
  • ISSN: 2044-5040
E-mail: nikolay [dot] oskolkov [at] biol [dot] lu [dot] se

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