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Nael Shaat

Physician

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The type 1 diabetes protective HLA DQB1*0602 allele is less frequent in gestational diabetes mellitus.

Author

  • Anastasia Papadopoulou
  • Kristian Lynch
  • Nael Shaat
  • Anita Nilsson
  • Barbro Lernmark
  • Kerstin Berntorp
  • S-A Ivarsson
  • Carl-David Agardh
  • Åke Lernmark
  • Annelie Carlsson

Summary, in English

AIMS/HYPOTHESIS: We tested whether gestational diabetes mellitus (GDM) is associated with HLA-DQ genotypes. METHODS: A total of 764 mothers with non-autoimmune (GAD65, insulinoma-associated protein 2 [IA-2] and insulin autoantibody-negative) GDM were ascertained between September 2000 and August 2004 in the population-based Diabetes Prediction in Skåne (DiPiS) study. HLA-DQB1 genotypes were determined in these mothers and in 1191 randomly selected non-diabetic control mothers also negative for islet autoantibodies. The data were analysed in relation to maternal age, country of birth, number of pregnancies/siblings and pregnancy weight gain. RESULTS: The frequency of type 1 diabetes high-risk HLA-DQ alleles (DQB1*0201, DQB1*0302) did not differ between GDM mothers and controls. In contrast, the low-risk DQB1*0602 allele was less prevalent (OR 0.64, 95% CI = 0.51-0.80, p = 0.0006) in GDM than in control mothers. The difference in DQB1*0602 frequency between GDM mothers and controls remained after multiple logistic regression analysis correcting for maternal age, country of birth, number of pregnancies/siblings and weight gain during pregnancy (OR 0.67, 95% CI 0.51-0.88, p = 0.009). CONCLUSIONS/INTERPRETATION: The negative association between mothers who have non-autoimmune GDM and HLA-DQ*0602 suggest that this allele may protect not only from type 1 diabetes but also from GDM.

Department/s

  • Celiac Disease and Diabetes Unit
  • Genomics, Diabetes and Endocrinology
  • Department of Clinical Sciences, Malmö
  • Paediatrics (Lund)
  • Pediatric Autoimmunity

Publishing year

2009

Language

English

Pages

1339-1342

Publication/Series

Diabetologia

Volume

52

Document type

Journal article

Publisher

Springer

Topic

  • Endocrinology and Diabetes

Status

Published

Research group

  • Diabetes and Celiac Unit
  • Genomics, Diabetes and Endocrinology
  • PediatricCeliaki/Diabetes

ISBN/ISSN/Other

  • ISSN: 1432-0428