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Mozhgan Dorkhan

Mozhgan Dorkhan

Specialist physician

Mozhgan Dorkhan

Relationship between natriuretic peptides and echocardiography parameters in patients with poorly regulated type 2 diabetes.

Author

  • Magnus Dencker
  • Martin Stagmo
  • Mozhgan Dorkhan

Summary, in English

This study evaluated the relationship between natriuretic peptide levels and a wide range of echocardiography parameters in a population of thirty-three patients with poorly regulated type 2 diabetes, and no known heart failure. Natriuretic peptides brain natriuretic peptide (BNP) and N-terminal prohormone BNP (NT-proBNP) were measured. Transthoracic echocardiography was performed and cardiac volumes and ejection fraction were measured. Doppler and tissue Doppler were measured and diastolic function was stratified according to recent guidelines. Very few echocardiography parameters were correlated with BNP or NT-proBNP levels. However, left atrial end-systolic volume indexed for body surface area was correlated with natural logarithm (ln) BNP and ln NT-proBNP (r=0.62 and r=0.60; P<0.05). There were significant differences in ln BNP and ln NT-proBNP levels between those with normal and those with abnormal diastolic function (1.4 vs 3.1; P<0.001 and 3.4 vs 5.8; P<0.001). This study showed that very few echocardiography parameters were correlated with BNP or NT-proBNP levels in patients with poorly regulated type 2 diabetes, which in part contradicts previous studies in other diabetic populations. The exception was left atrial end-systolic volume that showed a moderate correlation with BNP or NT-proBNP levels. There were significant differences in BNP and NT-proBNP levels between the group with normal left ventricular diastolic function and the group with abnormal diastolic function.

Department/s

  • Clinical Physiology, Malmö
  • Cardiology Research Group
  • Genomics, Diabetes and Endocrinology
  • EXODIAB: Excellence of Diabetes Research in Sweden

Publishing year

2010

Language

English

Pages

373-382

Publication/Series

Vascular Health and Risk Management

Volume

6

Document type

Journal article

Publisher

Dove Press

Topic

  • Cardiac and Cardiovascular Systems

Status

Published

Research group

  • Clinical Physiology, Malmö
  • Cardiology Research Group
  • Genomics, Diabetes and Endocrinology

ISBN/ISSN/Other

  • ISSN: 1178-2048