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Mikael Lantz

Mikael Lantz

Consultant

Mikael Lantz

Prevalence of diabetes and presence of autoantibodies against zinc transporter 8 and glutamic decarboxylase at diagnosis and at follow up of Graves’ disease

Author

  • Berglind Jonsdottir
  • Ida Jönsson
  • Mikael Lantz

Summary, in English

Purpose: The aim of this work was to investigate, in patients with newly diagnosed Graves’ disease (GD), the frequency of islet autoantibodies including autoantibodies against Zink transporter 8 (ZnT8A), as well as to investigate the relation between thyroid autoantibodies, islet autoantibodies and diabetes both before GD diagnosis and at follow-up. Methods: Blood samples from 278 patients with newly diagnosed GD were analyzed for autoantibodies against glutamic acid decarboxylase (GADA), insulinoma-associated protein-2 (IA2-A), three variants of zinc transporter 8 (ZnT8A), thyroid peroxidase (TPOA) and the TSH receptor (TRAb). Information on other autoimmune diseases, as well as development of diabetes during follow up was gathered from patient’s medical journal. Results: At GD diagnosis, 13.7% were positive for islet autoantibodies, with the majority being positive for GADA (8.7%) and ZnT8A (7.6%). TPOA were found positive in 71% and TRAb in 83%. No association was found between islet autoantibodies and thyroid autoantibodies or diabetes diagnosis during follow up. Positive association was found between islet autoantibodies and all forms of diabetes, diagnosed both before and after GD (OR: 2.5, CI: 1.1–6.8, p = 0.03) but not to other autoimmune diseases at GD diagnosis. Conclusions: The incidence of GADA and ZnT8A in patients with GD is high and might indicate wide range endocrine autoimmunity, as well as risk for non-autoimmune diabetes rather than exclusively mark beta cell autoimmunity and type 1 diabetes.

Department/s

  • Paediatric Endocrinology
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • Genomics, Diabetes and Endocrinology

Publishing year

2019-02-19

Language

English

Pages

48-54

Publication/Series

Endocrine

Volume

64

Issue

1

Document type

Journal article

Publisher

Humana Press

Topic

  • Endocrinology and Diabetes

Keywords

  • Diabetes
  • Graves’ disease
  • Islet autoantibodies
  • Thyroid autoantibodies

Status

Published

Research group

  • Paediatric Endocrinology
  • Genomics, Diabetes and Endocrinology

ISBN/ISSN/Other

  • ISSN: 1355-008X