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Soluble Urokinase Plasminogen Activator Receptor is Associated With Inflammation in the Vulnerable Human Atherosclerotic Plaque.

Author:
  • Andreas Edsfeldt
  • Mihaela Nitulescu
  • Helena Grufman
  • Caitriona Grönberg
  • Ana Persson
  • Marie MN Nilsson
  • Margaretha Persson
  • Harry Björkbacka
  • Isabel Goncalves
Publishing year: 2012
Language: English
Pages: 3305-3312
Publication/Series: Stroke; a journal of cerebral circulation
Volume: 43
Issue: 12
Document type: Journal article
Publisher: American Heart Association

Abstract english

Recently, plasma soluble urokinase plasminogen activator receptor (suPAR) has gained interest as a marker of cardiovascular risk. suPAR is released through the cleavage of urokinase plasminogen activator receptor (uPAR), which is found in monocytes, activated T-lymphocytes and endothelial cells, all involved in atherosclerosis. suPAR levels have been well studied in plasma, but no studies have focused on suPAR in human atherosclerotic plaques. The aim of this study was to determine whether suPAR measured in the plaque is associated with symptomatic plaques and plaque inflammation.

Keywords

  • Neurology

Other

Published
  • Cardiovascular Research - Immunity and Athersosclerosis
  • Internal Medicine - Epidemiology
  • ISSN: 1524-4628
E-mail: mihaela [dot] nitulescu [at] med [dot] lu [dot] se

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