
Mi Huang
Doctoral student

Key interests
Functional studies of Gene-Environment interactions on obesity and type 2 diabetes
Background/biography
Mi Huang finished his bachelor education in pharmacy (2014) and master education in pharmaceutical chemistry (2017) in South-central University for Nationalities in China. Before he joined Professor Paul Frank´s team, he had been focusing on the discovery of natural medicines against type 2 diabetes from traditional Chinese herbs. In 2018, he started his PhD study in GAME unit under the supervision of professor Paul Franks. In 2019.5 -2019.11, he visited Melina Claussnitzer´s lab in Broad Institute and got trained with CRISPR-SAVE technology. His PhD projects will use the strongest of our previously published candidates for gene x environment associations. After identification of a specific target for testing, CRISPR will be applied in the appropriate cell type. As this work will be focusing on type 2 diabetes, tissues of relevance include skeletal muscle, adipose, liver and beta-cells. Experience of working with these cell types is established at our institute.
Publications
Displaying of publications. Sorted by year, then title.
Genomic editing of metformin efficacy-associated genetic variants in SLC47A1 does not alter SLC47A1 expression
Sebastian Kalamajski, Mi Huang, Jonathan Dalla-Riva, Maria Keller, Adem Y Dawed, et al.
(2022) Human Molecular Genetics, 31 p.491-498
Journal articleCRISPR editing of the PPARGC1A Gly482ser (rs8192678) polymorphism in human white adipose cells shows differential effects on mitochondrial function and adipogenesis.
M. Huang, M. Claussnitzer, A. Saadat, Hindrik Mulder, Sebastian Kalamajski, et al.
(2021) Diabetologia, 64 p.159-159
Conference paper: abstract