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Photo: KG Pressfoto

Marju Orho-Melander

Professor

Photo: KG Pressfoto

The inverse association between a fish consumption biomarker and gingival inflammation and periodontitis : A population-based study

Author

  • Filip Ottosson
  • Lina Hultgren
  • Celine Fernandez
  • Gunnar Engström
  • Marju Orho-Melander
  • Cecilia Kennbäck
  • Margaretha Persson
  • Ryan T. Demmer
  • Olle Melander
  • Björn Klinge
  • Peter M. Nilsson
  • Daniel Jönsson

Summary, in English

Aim: The metabolite 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid (CMPF) is a fatty fish–intake biomarker. We investigated the association between plasma levels of CMPF in relation to gingival inflammation and periodontitis case definition, as well as the extent and severity variables. Materials and Methods: The Malmö Offspring Study is a population-based study, and the Malmö Offspring Dental Study (MODS) is its dental arm, including periodontal charting. Plasma CMPF was measured using liquid chromatography–mass spectrometry and studied in relation to periodontal diagnosis and parameters using multivariable linear or logistic regression modelling adjusting for age, sex, education, body mass index, fasting glucose, and smoking. Results: Metabolite data were available for 922 MODS participants. Higher CMPF levels were associated with less gingival inflammation (β = −2.12, p =.002) and lower odds of severe periodontitis (odds ratio [OR] = 0.74, 95% confidence interval [CI]: 0.56 to 0.98). Higher CMPF levels were also associated with more teeth (β = 0.19, p =.001), lower number of periodontal pockets (≥4 mm) (β = −1.07, p =.007), and lower odds of having two or more periodontal pockets of ≥6 mm (OR = 0.80, 95% CI: 0.65 to 0.98) in fully adjusted models. Conclusions: CMPF, a validated biomarker of fatty fish consumption, is associated with less periodontal inflammation and periodontitis. Residual confounding cannot be ruled out, and future studies are warranted.

Department/s

  • Cardiovascular Research - Hypertension
  • Cardiovascular Research - Epidemiology
  • EpiHealth: Epidemiology for Health
  • Diabetes - Cardiovascular Disease
  • Internal Medicine - Epidemiology

Publishing year

2022-04

Language

English

Pages

353-361

Publication/Series

Journal of Clinical Periodontology

Volume

49

Issue

4

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Dentistry

Keywords

  • CMPF
  • fish diet
  • gingival inflammation
  • metabolomics
  • periodontitis

Status

Published

Research group

  • Cardiovascular Research - Hypertension
  • Cardiovascular Research - Epidemiology
  • Diabetes - Cardiovascular Disease
  • Internal Medicine - Epidemiology

ISBN/ISSN/Other

  • ISSN: 0303-6979