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Photo: KG Pressfoto

Marju Orho-Melander

Professor

Photo: KG Pressfoto

Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

Author

  • Y Horikawa
  • N Oda
  • N J Cox
  • X Li
  • Marju Orho-Melander
  • M Hara
  • Y Hinokio
  • T H Lindner
  • H Mashima
  • P E Schwarz
  • L del Bosque-Plata
  • Y Horikawa
  • Y Oda
  • I Yoshiuchi
  • S Colilla
  • K S Polonsky
  • S Wei
  • P Concannon
  • N Iwasaki
  • J Schulze
  • Leslie J. Baier
  • Clifton Bogardus
  • Leif Groop
  • Eric Boerwinkle
  • Craig L. Hanis
  • Graeme I. Bell

Summary, in English

Type 2 or non-insulin-dependent diabetes mellitus (NIDDM) is the most common form of diabetes worldwide, affecting approximately 4% of the world's adult population. It is multifactorial in origin with both genetic and environmental factors contributing to its development. A genome-wide screen for type 2 diabetes genes carried out in Mexican Americans localized a susceptibility gene, designated NIDDM1, to chromosome 2. Here we describe the positional cloning of a gene located in the NIDDM1 region that shows association with type 2 diabetes in Mexican Americans and a Northern European population from the Botnia region of Finland. This putative diabetes-susceptibility gene encodes a ubiquitously expressed member of the calpain-like cysteine protease family, calpain-10 (CAPN10). This finding suggests a novel pathway that may contribute to the development of type 2 diabetes.

Department/s

  • Genomics, Diabetes and Endocrinology

Publishing year

2000

Language

English

Pages

163-175

Publication/Series

Nature Genetics

Volume

26

Issue

2

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Endocrinology and Diabetes

Status

Published

Research group

  • Genomics, Diabetes and Endocrinology

ISBN/ISSN/Other

  • ISSN: 1546-1718