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Photo: KG Pressfoto

Marju Orho-Melander

Professor

Photo: KG Pressfoto

Assessment of lifestyle factors helps to identify liver fibrosis due to non-alcoholic fatty liver disease in obesity

Author

  • Mari Lahelma
  • Panu K. Luukkonen
  • Sami Qadri
  • Noora Ahlholm
  • Susanna Lallukka-Brück
  • Kimmo Porthan
  • Anne Juuti
  • Henna Sammalkorpi
  • Anne K. Penttilä
  • Johanna Arola
  • Marju Orho-Melander
  • Hannele Yki-Järvinen

Summary, in English

Only some individuals with obesity develop liver fibrosis due to non-alcoholic fatty liver disease (NAFLD-fibrosis). We determined whether detailed assessment of lifestyle factors in addition to physical, biochemical and genetic factors helps in identification of these patients. A total of 100 patients with obesity (mean BMI 40.0 ± 0.6 kg/m2 ) referred for bariatric surgery at the Helsinki University Hospital underwent a liver biopsy to evaluate liver histology. Physical activity was determined by accelerometer recordings and by the Modifiable Activity Questionnaire, diet by the FINRISK Food Frequency Questionnaire, and other lifestyle factors, such as sleep patterns and smoking, by face-to-face interviews. Physical and biochemical parameters and genetic risk score (GRS based on variants in PNPLA3, TM6SF2, MBOAT7 and HSD17B13) were measured. Of all participants 49% had NAFLD-fibrosis. Independent predictors of NAFLD-fibrosis were low moderate-to-vigorous physical activity, high red meat intake, low carbohydrate intake, smoking, HbA1c, triglycerides and GRS. A model including these factors (areas under the receiver operating characteristics curve (AUROC) 0.90 (95% CI 0.84–0.96)) identified NAFLD-fibrosis significantly more accurately than a model including all but lifestyle factors (AUROC 0.82 (95% CI 0.73–0.91)) or models including lifestyle, physical and biochemical, or genetic factors alone. Assessment of lifestyle parameters in addition to physical, biochemical and genetic factors helps to identify obese patients with NAFLD-fibrosis.

Department/s

  • Diabetes - Cardiovascular Disease
  • EpiHealth: Epidemiology for Health
  • EXODIAB: Excellence of Diabetes Research in Sweden

Publishing year

2021

Language

English

Publication/Series

Nutrients

Volume

13

Issue

1

Document type

Journal article

Publisher

MDPI AG

Topic

  • Gastroenterology and Hepatology
  • Public Health, Global Health, Social Medicine and Epidemiology

Keywords

  • Diet
  • Glucose
  • Insulin
  • Physical activity
  • Stress

Status

Published

Research group

  • Diabetes - Cardiovascular Disease

ISBN/ISSN/Other

  • ISSN: 2072-6643