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Photo: KG Pressfoto

Marju Orho-Melander

Professor

Photo: KG Pressfoto

Diet quality and change in blood lipids during 16 years of follow-up and their interaction with genetic risk for dyslipidemia

Author

  • Emily Sonestedt
  • Sophie Hellstrand
  • Isabel Drake
  • Christina Alexandra Schulz
  • Ulrika Ericson
  • Joanna Hlebowicz
  • Margaretha M. Persson
  • Bo Gullberg
  • Bo Hedblad
  • Gunnar Engström
  • Marju Orho-Melander

Summary, in English

A high diet quality according to the Swedish nutrition recommendations is associated with a reduced risk of cardiovascular disease in the population-based Malmö Diet and Cancer cohort. To further clarify this protective association, we examined the association between high diet quality and change in triglycerides, high density lipoprotein-cholesterol (HDL-C), and low density lipoprotein-cholesterol (LDL-C) after 16 years of follow-up in 3152 individuals (61% women; 46–68 years at baseline). In addition, we examined if genetic risk scores composed of 80 lipid-associated genetic variants modify these associations. A diet quality index based on intakes of saturated fat, polyunsaturated fat, sucrose, fiber, fruit and vegetables, and fish was constructed. A high diet quality was associated with lower risk of developing high triglycerides (p = 0.02) and high LDL-C (p = 0.03) during follow-up compared with a low diet quality. We found an association between diet quality and long-term change in HDL-C only among those with lower genetic risk for low HDL-C as opposed to those with higher genetic risk (p-interaction = 0.04). Among those with lower genetic risk for low HDL-C, low diet quality was associated with decreased HDL-C during follow-up (p = 0.05). In conclusion, individuals with high adherence to the Swedish nutrition recommendation had lower risk of developing high triglycerides and LDL-C during 16 years of follow-up.

Department/s

  • Diabetes - Cardiovascular Disease
  • Cardiovascular Research - Immunity and Atherosclerosis
  • Internal Medicine - Epidemiology
  • Nutrition Epidemiology
  • Cardiovascular Research - Epidemiology
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2016-05-09

Language

English

Publication/Series

Nutrients

Volume

8

Issue

5

Document type

Journal article

Publisher

MDPI AG

Topic

  • Endocrinology and Diabetes

Keywords

  • Diet
  • Epidemiology
  • Genetics
  • Lipids
  • Lipoproteins
  • Nutrition

Status

Published

Project

  • Interaction between dietary factors and genetic risk for lipoprotein traits and cardiovascular disease

Research group

  • Diabetes - Cardiovascular Disease
  • Cardiovascular Research - Immunity and Atherosclerosis
  • Internal Medicine - Epidemiology
  • Nutrition Epidemiology
  • Cardiovascular Research - Epidemiology

ISBN/ISSN/Other

  • ISSN: 2072-6643