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Photo: KG Pressfoto

Marju Orho-Melander

Professor

Photo: KG Pressfoto

Association of Low-Density Lipoprotein Cholesterol-Related Genetic Variants With Aortic Valve Calcium and Incident Aortic Stenosis.

Author

  • Gustav Smith
  • Kevin Luk
  • Christina-Alexandra Schulz
  • James C Engert
  • Ron Do
  • George Hindy
  • Gull Rukh
  • Line Dufresne
  • Peter Almgren
  • David S Owens
  • Tamara B Harris
  • Gina M Peloso
  • Kathleen F Kerr
  • Quenna Wong
  • Albert V Smith
  • Matthew J Budoff
  • Jerome I Rotter
  • L Adrienne Cupples
  • Stephen Rich
  • Sekar Kathiresan
  • Marju Orho-Melander
  • Vilmundur Gudnason
  • Christopher J O'Donnell
  • Wendy S Post
  • George Thanassoulis

Summary, in English

Plasma low-density lipoprotein cholesterol (LDL-C) has been associated with aortic stenosis in observational studies; however, randomized trials with cholesterol-lowering therapies in individuals with established valve disease have failed to demonstrate reduced disease progression.

Department/s

  • Cardiology
  • Diabetes - Cardiovascular Disease
  • Genomics, Diabetes and Endocrinology
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2014

Language

English

Pages

1764-1771

Publication/Series

JAMA: The Journal of the American Medical Association

Volume

312

Issue

17

Document type

Journal article

Publisher

American Medical Association

Topic

  • Endocrinology and Diabetes

Status

Published

Research group

  • Diabetes - Cardiovascular Disease
  • Genomics, Diabetes and Endocrinology

ISBN/ISSN/Other

  • ISSN: 1538-3598