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Photo: KG Pressfoto

Marju Orho-Melander

Professor

Photo: KG Pressfoto

Association between a polymorphism in the carboxyl ester lipase gene and serum cholesterol profile

Author

  • SH Bengtsson-Ellmark
  • J Nilsson
  • Marju Orho-Melander
  • K Dahlenborg
  • Leif Groop
  • G Bjursell

Summary, in English

Carboxyl ester lipase (CEL) is involved in the hydrolysis and absorption of dietary lipids, but it is largely unknown to what extent CEL could be involved in determining the serum lipid levels. The C-terminal part of CEL consists of a unique structure with proline-rich O-glycosylated repeats of 11 amino-acid residues each. The common variant of the human CEL gene contains 16 proline-rich repeats, but there is a high degree of polymorphism in the repeated region. While the biological function of the polymorphic repeat region is unknown, it has been suggested that it may be important for protein stability and/or secretion of the enzyme. Given that the polymorphism in the repeated region may affect the functionality of the protein, this study aimed to investigate whether the number of repeated units is correlated to serum lipid phenotype. Comparison of CEL repeat genotype and serum lipid phenotype revealed an association between the number of repeats and serum cholesterol profile. Individuals carrying at least one allele with fewer than the common 16 repeats had significantly lower total and low-density lipoprotein (LDL) cholesterol levels compared to individuals carrying two common alleles. This gives support to the notion that CEL may be involved in determining the plasma lipid composition.

Department/s

  • Genomics, Diabetes and Endocrinology

Publishing year

2004

Language

English

Pages

627-632

Publication/Series

European Journal of Human Genetics

Volume

12

Issue

8

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Medical Genetics

Keywords

  • cholesterol
  • polymorphism
  • repeats
  • LDL
  • CEL
  • lipase

Status

Published

Research group

  • Genomics, Diabetes and Endocrinology

ISBN/ISSN/Other

  • ISSN: 1476-5438