
Marju Orho-Melander
Professor

Biography
Marju Orho-Melander is professor of genetic epidemiology at the Department of Clinical Sciences at the Lund University, Sweden. She has MSc in biochemistry from Helsinki University 1995 and she defended her PhD thesis in experimental endocrinology on studies of the human glycogen synthase genes in 1999.
Orho-Melander has focused on identification of genes regulating lipid and lipoprotein levels using genome wide association studies and utilizes this information to predict cardiovascular disease in population. Second main field of focus of her research group is interaction between genes and diet in type 2 diabetes (T2D), obesity and cardiovascular disease. Her third focus area of research is biomarkers and environmental risk factors linking cardiometabolic disease and cancer. Until today (Sept 2014) Orho-Melander has published 124 papers in international peer reviewed scientific journals and these have been cited >9000 times excluding own citations (h-index 42).
Research Area
The purpose of her current main projects is to provide novel understanding of causal connections between cardiometabolic traits and incidence of T2D, cardiovascular disease CVD, and certain cancer forms. Her research group further continues with systematic studies on interactions between genetic and dietary risk factors for cardiometabolic disease, now aiming to clarify their connection to gut microbiota and certain cancer forms. Investigating the complex interactions between dietary factors, genetic risk factors, circulating biomarkers and gut microbiota constitution in a comprehensive prospective cohort study design is a crucial first step to allow for subsequent intervention studies. The longer term purpose of the work of Orho-Melanders group is to provide novel intervention strategies aiming to more effective prevention of cardiometabolic diseases and cancer.
Research Group
Today the Orho-Melander group includes four post-doctoral fellows, six PhD students, one laboratory engineer and a research administrator. The group members have basic education in the fields of biochemistry, medicine, nutrition, molecular biology and public health and the post-doctoral fellows are experienced in the fields of nutrition and genetic epidemiology, cardiometabolic disease and cancer epidemiology and bioinformatics.
Grant Support
The Swedish Research Council, The Swedish Heart and Lung Foundation, The Påhlsson Foundation, The Novo Nordisk Foundation, The Swedish Diabetes Foundation, The Region Skåne (ALF), The Knut and Alice Wallenberg Foudnation.
Ten selected papers
1. Ahmad S, Rukh G, Varga TV, Ali A, Kurbasic A, Shungin D, Ericson U, Koivula RW, Chu AY, Rose LM, Ganna A, Qi Q, Stančáková A, Sandholt CH, Elks CE, Curhan G, Jensen MK, Tamimi RM, Allin KH, Jørgensen T, Brage S, Langenberg C, Aadahl M, Grarup N, Linneberg A, Paré G; InterAct Consortium; DIRECT Consortium, Magnusson PK, Pedersen NL, Boehnke M, Hamsten A, Mohlke KL, Pasquale LT, Pedersen O, Scott RA, Ridker PM, Ingelsson E, Laakso M, Hansen T, Qi L, Wareham NJ, Chasman DI, Hallmans G, Hu FB, Renström F, Orho-Melander M, Franks PW: Gene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry. PLoS Genet. Jul;9(7):e1003607, 2013
2. Melander O, Maisel AS, Almgren P, Manjer J, Belting M, Hedblad B, Engström G, Kilger U, Nilsson P, Bergmann A, Orho-Melander M. Plasma proneurotensin and incidence of diabetes, cardiovascular disease, breast cancer, and mortality. JAMA. 308:1469-75, 2012
3. Hindy G, Sonestedt E, Ericson U, Jing XJ, Zhou Y, Hansson O, Renström E, Wirfält E, Orho-Melander M: Role of TCF7L2 risk variant and dietary fibre intake on incident type 2 diabetes. Diabetologia 55:2646-54, 2012
4. Voight BF*, Peloso GM*, Orho-Melander M, Frikke-Schmidt R, Barbalic M, Jensen MK, Hindy G, Hólm H, Ding EL, Johnson T, Schunkert H, Samani NJ, Clarke R, Hopewell JC, Thompson JF, Li M, Thorleifsson G, Newton-Cheh C, Musunuru K, Pirruccello JP, Saleheen D, Chen L, Stewart A, Schillert A, Thorsteinsdottir U, Thorgeirsson G, Anand S, Engert JC, Morgan T, Spertus J, Stoll M, Berger K, Martinelli N, Girelli D, McKeown PP, Patterson CC, Epstein SE, Devaney J, Burnett MS, Mooser V, Ripatti S, Surakka I, Nieminen MS, Sinisalo J, Lokki ML, Perola M, Havulinna A, de Faire U, Gigante B, Ingelsson E, Zeller T, Wild P, de Bakker PI, Klungel OH, Maitland-van der Zee AH, Peters BJ, de Boer A, Grobbee DE, Kamphuisen PW, Deneer VH, Elbers CC, Onland-Moret NC, Hofker MH, Wijmenga C, Verschuren WM, Boer JM, van der Schouw YT, Rasheed A, Frossard P, Demissie S, Willer C, Do R, Ordovas JM, Abecasis GR, Boehnke M, Mohlke KL, Daly MJ, Guiducci C, Burtt NP, Surti A, Gonzalez E, Purcell S, Gabriel S, Marrugat J, Peden J, Erdmann J, Diemert P, Willenborg C, König IR, Fischer M, Hengstenberg C, Ziegler A, Buysschaert I, Lambrechts D, Van de Werf F, Fox KA, El Mokhtari NE, Rubin D, Schrezenmeir J, Schreiber S, Schäfer A, Danesh J, Blankenberg S, Roberts R, McPherson R, Watkins H, Hall AS, Overvad K, Rimm E, Boerwinkle E, Tybjaerg-Hansen A, Cupples LA, Reilly MP, Melander O, Mannucci PM, Ardissino D, Siscovick D, Elosua R, Stefansson K, O'Donnell CJ, Salomaa V, Rader DJ, Peltonen L, Schwartz SM, Altshuler D, Kathiresan S: Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet 380: 572-80, 2012
5. Musunuru K, Strong A, Frank-Kamenetsky M, Wong J, Cantley W, Li H, Ejebe KG, Schadt EE, Orho-Melander M, Melander O, Cowan CA, Koteliansky V, Fitzgerald K, Krauss RM, Kathiresan S, Rader DJ: From DNA sequence variant to lipoprotein phenotype at a novel cholesterol and myocardial infarction locus. Nature 466: 714-719, 2010
6. Sonestedt E, Roos C, Gullberg B, Ericson U, Wirfält E and Orho-Melander M: Fat and carbohydrate intake modify the association between genetic variation in FTO and obesity. Am J Clin Nutr 90: 1418-1425, 2009
7. Orho-Melander M, Melander O, Guiducci C, Perez-Martinez P, Corella C, Roos C, Rieder MJ, Abecasis G, Tai ES, Arnett DK, Lyssenko V, Lindholm E Saxena R, de Bakker P, Burtt N, Voight B, Hirschorn JN, Tucker KL, Hedner T, Tuomi T, Isomaa B, Eriksson K-F, Taskinen M-R, Hughes TE, Parnell LD, Lai C-Q, Peltonen L, Vartiainen L, Jousilahti P, Havulinna AS, Salomaa V, Groop L, Altshuler D, Ordovas JM & Kathiresan S. A common missense variant in the glucokinase regulatory protein (GCKR) gene is associated with increased plasma triglyceride but lower fasting glucose levels. Diabetes, 57: 3112-21, 2008
8. Kathiresan S, Melander O, Roos C, Guiducci C, Burtt N, Anevski D, Hirschhorn J, Berglund G., Hedblad B., Groop, L, Altshuler D, Newton Cheh C, Orho-Melander M: Polymorphisms associated with cholesterol and risk of cardiovascular events. N Engl J Med 358:1240-9, 2008
9. Kathiresan S, Melander O, Guiducci C, Surti.A., Burtt NP, Rieder MJ, Cooper GM, Roos C, Voight BF, Havilunna AS, Hedner T, Berglund G, Vartianen E, Jousilahti P, Hedblad B, Newton-Cheh C, Salomaa V, Peltonen L, Groop L, Altshuler DM, Orho-Melander M: Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans, Nat Genet 40:189-97, 2008
10. Orho M., Bosshard N.U., Buist N.R.M., Gitzelmann R., Aynsley-Green A., Blumel P., Gannon M.C., Nuttall F.Q. and Groop L.C.: Mutations in the liver glycogen synthase gene in children with hypoglycemia due to glycogen storage disease type 0. Journal of Clinical Investigation 102: 507-515, 1998.
Publications
Displaying of publications. Sorted by year, then title.
Increased soluble urokinase plasminogen activator levels modulate monocyte function to promote atherosclerosis
George Hindy, Daniel J. Tyrrell, Alexi Vasbinder, Changli Wei, Feriel Presswalla, et al.
(2022) Journal of Clinical Investigation, 132 p.1-14
Journal articleA healthy dietary metabolic signature is associated with a lower risk for type 2 diabetes and coronary artery disease
Einar Smith, Ulrika Ericson, Sophie Hellstrand, Marju Orho-Melander, Peter M. Nilsson, et al.
(2022) BMC Medicine, 20
Journal articleDiscovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants
Krishna G Aragam, George Hindy, Satoshi Koyama, Olle Melander, Marju Orho-Melander, et al.
(2022) Nature Genetics, 54 p.1803-1815
Journal articleAn online atlas of human plasma metabolite signatures of gut microbiome composition
Koen F. Dekkers, Sergi Sayols-Baixeras, Gabriel Baldanzi, Christoph Nowak, Ulf Hammar, et al.
(2022) Nature Communications, 13
Journal articleGenetic risk of type 2 diabetes modifies the effects of a lifestyle intervention aimed at the prevention of gestational and postpartum diabetes
Emilia Huvinen, Jari Lahti, Miira M. Klemetti, Paula H. Bergman, Katri Räikkönen, et al.
(2022) Diabetologia, 65 p.1291-1301
Journal articleProteomic Profiles of Body Mass Index and Waist-to-Hip Ratio and Their Role in Incidence of Diabetes
Xue Bao, Biao Xu, Songjiang Yin, Jingxue Pan, Peter M. Nilsson, et al.
(2022) Journal of Clinical Endocrinology and Metabolism, 107 p.2982-2990
Journal articleThe inverse association between a fish consumption biomarker and gingival inflammation and periodontitis : A population-based study
Filip Ottosson, Lina Hultgren, Celine Fernandez, Gunnar Engström, Marju Orho-Melander, et al.
(2022) Journal of Clinical Periodontology, 49 p.353-361
Journal articleMetabolome-Defined Obesity and the Risk of Future Type 2 Diabetes and Mortality
Filip Ottosson, Einar Smith, Ulrika Ericson, Louise Brunkwall, Marju Orho-Melander, et al.
(2022) Diabetes Care, 45 p.1260-1267
Journal articleOsteomodulin Gene Expression Is Associated with Plaque Calcification, Stability, and Fewer Cardiovascular Events in the CPIP Cohort
Isabel Gonçalves, Loureen Oduor, Frank Matthes, Narjess Rakem, Jakob Meryn, et al.
(2022) Stroke, 53 p.79-84
Journal articleDistinct contributions of metabolic dysfunction and genetic risk factors in the pathogenesis of non-alcoholic fatty liver disease
Panu K. Luukkonen, Sami Qadri, Noora Ahlholm, Kimmo Porthan, Ville Männistö, et al.
(2022) Journal of Hepatology, 76 p.526-535
Journal articlePlasma Proneurotensin and Prediction of Cause-Specific Mortality in a Middle-aged Cohort During Long-term Follow-up
Ayesha Fawad, Andreas Bergmann, Janin Schulte, Zahra A Butt, Peter M Nilsson, et al.
(2022) The Journal of clinical endocrinology and metabolism, 107 p.1204-1211
Journal articleHigh levels of autoantibodies against apoB100 p210 are associated with lower incidence of atrial fibrillation in women
Kari Anne Sveen, Gustav Smith, Harry Björkbacka, Marju Orho-Melander, Gunnar Engström, et al.
(2022) Journal of Internal Medicine, 291 p.207-217
Journal articleInterferon regulatory factor-5-dependent CD11c+ macrophages contribute to the formation of rupture-prone atherosclerotic plaques
Andreas Edsfeldt, Maarten Swart, Pratibha Singh, Lea Dib, Jiangming Sun, et al.
(2022) European Heart Journal, 43 p.1864-1877
Journal articleCirculating Hepatocyte Growth Factor Reflects Activation of Vascular Repair in Response to Stress
Yihong Chen, Junyan Shen, Anna Hultgårdh Nilsson, Isabel Goncalves, Andreas Edsfeldt, et al.
(2022) JACC: Basic to Translational Science, 7 p.747-762
Journal articleObesity Partially Mediates the Diabetogenic Effect of Lowering LDL Cholesterol
P Wu, George Hindy, Ulrika Ericson, Marju Orho-Melander, Jordi Merino
(2022) Diabetes Care, 45 p.232-240
Journal articleThe role of circulating galectin-1 in type 2 diabetes and chronic kidney disease : evidence from cross-sectional, longitudinal and Mendelian randomisation analyses
Isabel Drake, Emanuel Fryk, Lena Strindberg, Annika Lundqvist, Anders H. Rosengren, et al.
(2022) Diabetologia, 65 p.128-139
Journal articleDifferential and shared genetic effects on kidney function between diabetic and non-diabetic individuals
T.W. Winkler, C.-A. Schulz, M. Orho-Melander, O. Melander, Iris M. Heid
(2022) Communications Biology, 5
Journal articleMultiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes
P. Akbari, A. Giontella, M. Orho-Melander, O. Melander, Luca A. Lotta
(2022) Nature Communications, 13
Journal articleGenetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies
M. Gorski, O. Melander, M. Orho-Melander, C.-A. Schulz, I.M. Heid
(2022) Kidney International , p.624-639
Journal articleInteraction between blood pressure and genetic risk score for bladder cancer, and risk of urothelial carcinoma in men
Stanley Teleka, Marju Orho-Melander, Fredrik Liedberg, Olle Melander, Karin Jirström, et al.
(2022) Scientific Reports, 12
Journal articleGenome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention
Z. Wang, C.-A. Schulz, E. Sonestedt, M. Orho-Melander, M. Hoed
(2022) Nature Genetics, 54 p.1332-1344
Journal articleRare coding variants in 35 genes associate with circulating lipid levels—A multi-ancestry analysis of 170,000 exomes
George Hindy, Leif Groop, Valeriya Lyssenko, Olle Melander, Peter M Nilsson, et al.
(2022) American Journal of Human Genetics, 109 p.81-96
Journal articleGrowth differentiation factor-15 and incident chronic kidney disease : a population-based cohort study
Xue Bao, Biao Xu, Yan Borné, Marju Orho-Melander, Olle Melander, et al.
(2021) BMC Nephrology, 22
Journal articleTranslating polygenic risk scores for clinical use by estimating the confidence bounds of risk prediction
Jiangming Sun, Yunpeng Wang, Lasse Folkersen, Yan Borné, Inge Amlien, et al.
(2021) Nature Communications, 12 p.5276-5276
Journal articleGut microbiota composition in relation to intake of added sugar, sugar-sweetened beverages and artificially sweetened beverages in the Malmö Offspring Study
Stina Ramne, Louise Brunkwall, Ulrika Ericson, Nicola Gray, Gunter G C Kuhnle, et al.
(2021) European Journal of Nutrition, 60 p.2087-2097
Journal articlePrecisionsmedicin kan bli viktig även vid komplexa sjukdomar
Erik Melén, Bo Jacobsson, Mikael Benson, Marju Orho-Melander, Jonas Halvarson, et al.
(2021) Lakartidningen, 118
Journal articleDietary Data in the Malmö Offspring Study : Reproducibility, Method Comparison and Validation against Objective Biomarkers
Sophie Hellstrand, Filip Ottosson, Einar Smith, Louise Brunkwall, Stina Ramne, et al.
(2021) Nutrients, 13
Journal articleEstimated salt intake and risk of atrial fibrillation in a prospective community-based cohort
J. Wuopio, M. Orho-Melander, J. Ärnlöv, C. Nowak
(2021) Journal of Internal Medicine, 289 p.700-708
Journal articlePlasma Protein Profile of Carotid Artery Atherosclerosis and Atherosclerotic Outcomes : Meta-Analyses and Mendelian Randomization Analyses
Lars Lind, Bruna Gigante, Yan Borné, Tobias Feldreich, Jerzy Leppert, et al.
(2021) Arteriosclerosis, Thrombosis, and Vascular Biology, 41
Journal articleAssociations Between Endometriosis and Gut Microbiota
Agnes Svensson, Louise Brunkwall, Bodil Roth, Marju Orho-Melander, Bodil Ohlsson
(2021) Reproductive Sciences, 28 p.2367-2377
Journal articleCirculating Vimentin Is Associated With Future Incidence of Stroke in a Population-Based Cohort Study
Jun Xiao, Liangwan Chen, Olle Melander, Marju Orho-Melander, Jan Nilsson, et al.
(2021) Stroke: a journal of cerebral circulation, 52 p.937-944
Journal articleComparison of cardiovascular disease and cancer prevalence between Mediterranean and north European middle-aged populations (The Cilento on Ageing Outcomes Study and The Malmö Offspring Study)
Olle Melander, Paola Antonini, Filip Ottosson, Louise Brunkwall, Widet Gallo, et al.
(2021) Internal and Emergency Medicine, 16 p.1567-1572
Journal articleAssociation between blood pressure and BMI with bladder cancer risk and mortality in 340,000 men in three Swedish cohorts
Stanley Teleka, Sylvia H.J. Jochems, Christel Häggström, Angela M. Wood, Bengt Järvholm, et al.
(2021) Cancer Medicine, 10 p.1431-1438
Journal articleThe associations between red cell distribution width and plasma proteins in a general population
Jingxue Pan, Yan Borné, Marju Orho-Melander, Jan Nilsson, Olle Melander, et al.
(2021) Clinical Proteomics, 18
Journal articleTechnological readiness and implementation of genomic-driven precision medicine for complex diseases
P. W. Franks, E. Melén, M. Friedman, J. Sundström, I. Kockum, et al.
(2021) Journal of Internal Medicine, 290 p.602-620
Journal article reviewMethodological considerations for identifying multiple plasma proteins associated with all-cause mortality in a population-based prospective cohort
Isabel Drake, George Hindy, Peter Almgren, Gunnar Engström, Jan Nilsson, et al.
(2021) Scientific Reports, 11
Journal articleWaist circumference and a body shape index and prostate cancer risk and mortality
Sylvia Jochems, Angela M Wood, Christel Häggström, Marju Orho-Melander, Pär Stattin, et al.
(2021) Cancer Medicine, 10 p.2885-2896
Journal articleAssessment of lifestyle factors helps to identify liver fibrosis due to non-alcoholic fatty liver disease in obesity
Mari Lahelma, Panu K. Luukkonen, Sami Qadri, Noora Ahlholm, Susanna Lallukka-Brück, et al.
(2021) Nutrients, 13
Journal articlePlasma S1P (Sphingosine-1-Phosphate) Links to Hypertension and Biomarkers of Inflammation and Cardiovascular Disease : Findings From a Translational Investigation
Amra Jujic, Frank Matthes, Lotte Vanherle, Henning Petzka, Marju Orho-Melander, et al.
(2021) Hypertension, 78 p.195-209
Journal articleAssociation of Sleep Duration with All- And Major-Cause Mortality among Adults in Japan, China, Singapore, and Korea
Thomas Svensson, Eiko Saito, Akiko Kishi Svensson, Olle Melander, Marju Orho-Melander, et al.
(2021) JAMA Network Open, 4
Journal articleGrowth differentiation factor-15 is a biomarker for all-cause mortality but less evident for cardiovascular outcomes : A prospective study
Xue Bao, Yan Borné, Biao Xu, Marju Orho-Melander, Jan Nilsson, et al.
(2021) American Heart Journal, 234 p.81-89
Journal articleAssociation of Circulating Monocyte Chemoattractant Protein-1 Levels with Cardiovascular Mortality : A Meta-analysis of Population-Based Studies
Marios K. Georgakis, James A. De Lemos, Colby Ayers, Biqi Wang, Harry Björkbacka, et al.
(2021) JAMA Cardiology, 6 p.587-592
Journal articleThe Malmö Offspring Study (MOS) : design, methods and first results
Louise Brunkwall, Daniel Jönsson, Ulrika Ericson, Sophie Hellstrand, Cecilia Kennbäck, et al.
(2021) European Journal of Epidemiology, 36 p.103-116
Journal articleThe PNPLA3-I148M Variant Confers an Antiatherogenic Lipid Profile in Insulin-resistant Patients
Panu K. Luukkonen, Sami Qadri, Tiina E. Lehtimäki, Anne Juuti, Henna Sammalkorpi, et al.
(2021) The Journal of clinical endocrinology and metabolism, 106 p.300-315
Journal articleEffect of AMY1 copy number variation and various doses of starch intake on glucose homeostasis : data from a cross-sectional observational study and a crossover meal study
Mary Farrell, Stina Ramne, Phébée Gouinguenet, Louise Brunkwall, Ulrika Ericson, et al.
(2021) Genes & Nutrition, 16 p.1-12
Journal articleElevated circulating follistatin associates with an increased risk of type 2 diabetes
Chuanyan Wu, Yan Borné, Rui Gao, Maykel López Rodriguez, William C Roell, et al.
(2021) Nature Communications, 12 p.1-10
Journal articleHyperglycaemia-associated Caspase-3 predicts diabetes and coronary artery disease events
Jiangming Sun, Pratibha Singh, Johan Österlund, Marju Orho-Melander, Olle Melander, et al.
(2021) Journal of Internal Medicine, 290 p.855-865
Journal articleSelf-reported bowel symptoms are associated with differences in overall gut microbiota composition and enrichment of Blautia in a population-based cohort
Louise Brunkwall, Ulrika Ericson, Peter M. Nilsson, Marju Orho-Melander, Bodil Ohlsson
(2021) Journal of Gastroenterology and Hepatology, 36 p.174-180
Journal articleHeight, body mass index and prostate cancer risk and mortality by way of detection and cancer risk category
Sylvia H.J. Jochems, Pär Stattin, Christel Häggström, Bengt Järvholm, Marju Orho-Melander, et al.
(2020) International Journal of Cancer, 147 p.3328-3338
Journal articleThe gut microbiota-related metabolite phenylacetylglutamine associates with increased risk of incident coronary artery disease
Filip Ottosson, Louise Brunkwall, Einar Smith, Marju Orho-Melander, Peter M. Nilsson, et al.
(2020) Journal of Hypertension, 38 p.2427-2434
Journal articleThe proteoglycan mimecan is associated with carotid plaque vulnerability and increased risk of future cardiovascular death
Christoffer Tengryd, Signe Holm Nielsen, Michele Cavalera, Eva Bengtsson, Federica Genovese, et al.
(2020) Atherosclerosis, 313 p.88-95
Journal articleMeta-analysis uncovers genome-wide significant variants for rapid kidney function decline
Mathias Gorski, Iris M. Heid
(2020) Kidney International, 99 p.926-939
Journal articleIdentification of Inflammatory and Disease-Associated Plasma Proteins that Associate with Intake of Added Sugar and Sugar-Sweetened Beverages and Their Role in Type 2 Diabetes Risk
Stina Ramne, Isabel Drake, Ulrika Ericson, Jan Nilsson, Marju Orho-Melander, et al.
(2020) Nutrients, 12
Journal articleGenomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals
Lasse Folkersen, Stefan Gustafsson, Qin Wang, Daniel Hvidberg Hansen, Åsa K Hedman, et al.
(2020) Nature Metabolism, 2 p.1135-1148
Journal articleMARC1 variant rs2642438 increases hepatic phosphatidylcholines and decreases severity of non-alcoholic fatty liver disease in humans
Panu K. Luukkonen, Anne Juuti, Henna Sammalkorpi, Anne K. Penttilä, Matej Orešič, et al.
(2020) Journal of Hepatology, 73 p.725-726
Journal article (letter)The PNPLA3-I148M variant increases polyunsaturated triglycerides in human adipose tissue
Sami Qadri, Susanna Lallukka-Brück, Panu K. Luukkonen, You Zhou, Amalia Gastaldelli, et al.
(2020) Liver International, 40 p.2128-2138
Journal articleCirculating protein biomarkers predict incident hypertensive heart failure independently of N-terminal pro-B-type natriuretic peptide levels
Celine Fernandez, Jaana Rysä, Kristoffer Ström, Jan Nilsson, Gunnar Engström, et al.
(2020) ESC Heart Failure, 7 p.1891-1899
Journal articleMendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood
Yan Zheng, Angela Estampador, Tibor V. Varga, Marju Orho-Melander, Christina-Alexandra Schulz, et al.
(2020) European Journal of Epidemiology, 35 p.685-697
Journal articleComparing Self-Reported Sugar Intake With the Sucrose and Fructose Biomarker From Overnight Urine Samples in Relation to Cardiometabolic Risk Factors
Stina Ramne, Nicola Gray, Sophie Hellstrand, Louise Brunkwall, Sofia Enhörning, et al.
(2020) Frontiers in nutrition, 7
Journal articleHydroxysteroid 17-β dehydrogenase 13 variant increases phospholipids and protects against fibrosis in nonalcoholic fatty liver disease
Panu K. Luukkonen, Taru Tukiainen, Anne Juuti, Henna Sammalkorpi, P. A. Nidhina Haridas, et al.
(2020) JCI Insight, 5
Journal articleLifestyle and cancer incidence and mortality risk depending on family history of cancer in two prospective cohorts
Isabel Drake, Joana Alves Dias, Stanley Teleka, Tanja Stocks, Marju Orho-Melander
(2020) International Journal of Cancer, 146 p.1198-1207
Journal articlePeriodontal disease is associated with carotid plaque area: the Malmö Offspring Dental Study (MODS).
D. Jönsson, M. Orho-Melander, R. T. Demmer, G. Engström, O. Melander, et al.
(2020) Journal of Internal Medicine, 287 p.301-309
Journal articlePlasma kidney injury molecule-1 (p-KIM-1) levels and deterioration of kidney function over 16 years
Christina-Alexandra Schulz, Gunnar Engström, Jan Nilsson, Peter Almgren, Marinka Petkovic, et al.
(2020) Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 35 p.265-273
Journal articlePlasma Lipidome and Prediction of Type 2 Diabetes in the Population-Based Malmö Diet and Cancer Cohort
Céline Fernandez, Michal A. Surma, Christian Klose, Mathias J. Gerl, Filip Ottosson, et al.
(2020) Diabetes Care, 43 p.366-373
Journal articleBlood pressure and bladder cancer risk in men by use of survival analysis and in interaction with NAT2 genotype, and by Mendelian randomization analysis
Stanley Teleka, George Hindy, Isabel Drake, Alaitz Poveda, Olle Melander, et al.
(2020) PLoS ONE, 15
Journal articleDiscovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
Praveen Surendran, Cristiano Fava, Olle Melander, Marju Orho-Melander, Alaitz Poveda, et al.
(2020) Nature Genetics, 52 p.1314-1332
Journal articleEvidence for a protective role of placental growth factor in cardiovascular disease
Yihong Chen, Anna Hultgårdh Nilsson, Isabel Goncalves, Andreas Edsfeldt, Gunnar Engström, et al.
(2020) Science Translational Medicine, 12
Journal articleThe plasma protein profile and cardiovascular risk differ between intima-media thickness of the common carotid artery and the bulb : A meta-analysis and a longitudinal evaluation
Lars Lind, Bruna Gigante, Yan Borne, Anders Mälarstig, Johan Sundström, et al.
(2020) Atherosclerosis, 295 p.25-30
Journal articleAbdominal Fat and Metabolic Health Markers but Not PNPLA3 Genotype Predicts Liver Fat Accumulation in Response to Excess Intake of Energy and Saturated Fat in Healthy Individuals
Fredrik Rosqvist, Marju Orho-Melander, Joel Kullberg, David Iggman, Hans Erik Johansson, et al.
(2020) Frontiers in nutrition, 7
Journal articleReduced oxidized LDL in T2D plaques is associated with a greater statin usage but not with future cardiovascular events
Pratibha Singh, Isabel Goncalves, Christoffer Tengryd, Mihaela Nitulescu, Ana F. Persson, et al.
(2020) Cardiovascular Diabetology, 19
Journal articleMagnitude of rise in proneurotensin is related to amount of triglyceride appearance in blood after standardized oral intake of both saturated and unsaturated fat
Ayesha Fawad, Celine Fernandez, Andreas Bergmann, Joachim Struck, Peter M. Nilsson, et al.
(2020) Lipids in Health and Disease, 19
Journal articleGenome-Wide Polygenic Score, Clinical Risk Factors, and Long-Term Trajectories of Coronary Artery Disease
George Hindy, Krishna G. Aragam, Kenney Ng, Mark Chaffin, Luca A. Lotta, et al.
(2020) Arteriosclerosis, Thrombosis, and Vascular Biology, 40 p.2738-2746
Journal articleA Health-Conscious Food Pattern Is Associated with Prediabetes and Gut Microbiota in the Malmö Offspring Study
Ulrika Ericson, Louise Brunkwall, Sophie Hellstrand, Peter M. Nilsson, Marju Orho-Melander
(2020) Journal of Nutrition, 150 p.861-872
Journal articleAssociation of TIM-1 (T-Cell Immunoglobulin and Mucin Domain 1) With Incidence of Stroke
Lu Song, Jiangming Sun, Martin Söderholm, Olle Melander, Marju Orho-Melander, et al.
(2020) Arteriosclerosis, Thrombosis, and Vascular Biology, 40 p.1777-1786
Journal articleGenome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium
Jordi Merino, Hassan S. Dashti, Sherly X. Li, Chloé Sarnowski, Anne E. Justice, et al.
(2019) Molecular Psychiatry, 24 p.1920-1932
Journal articleA favorable lifestyle lowers the risk of coronary artery disease consistently across strata of non-modifiable risk factors in a population-based cohort
Kristian Dimovski, Marju Orho-Melander, Isabel Drake
(2019) BMC Public Health, 19
Journal articleThe associations of self-rated health with cardiovascular risk proteins : A proteomics approach
Xue Bao, Yan Borné, Songjiang Yin, Kaijun Niu, Marju Orho-Melander, et al.
(2019) Clinical Proteomics, 16
Journal articleHuman PNPLA3-I148M variant increases hepatic retention of polyunsaturated fatty acids
Panu K. Luukkonen, Auli Nick, Maarit Hölttä-Vuori, Christoph Thiele, Elina Isokuortti, et al.
(2019) JCI Insight, 4
Journal articleCirculating HER2/ErbB2 Levels Are Associated With Increased Incidence of Diabetes : A Population-Based Cohort Study
Iram Faqir Muhammad, Yan Borné, Xue Bao, Olle Melander, Marju Orho-Melander, et al.
(2019) Diabetes Care, 42 p.1582-1588
Journal articleSeleno protein-P deficiency predicts cardiovascular disease and death
Lutz Schomburg, Marju Orho-Melander, Joachim Struck, Andreas Bergmann, Olle Melander
(2019) Nutrients, 11
Journal articleGenome-wide analysis of dental caries and periodontitis combining clinical and self-reported data
Dmitry Shungin, Simon Haworth, Kimon Divaris, Cary S. Agler, Yoichiro Kamatani, et al.
(2019) Nature Communications, 10
Journal articleA catalog of genetic loci associated with kidney function from analyses of a million individuals
Matthias Wuttke, Peter Almgren, Cecilia M Lindgren, Olle Melander, Marju Orho-Melander, et al.
(2019) Nature Genetics, 51 p.957-972
Journal articleGenetic Predisposition for Renal Dysfunction and Incidence of CKD in the Malmö Diet and Cancer Study
Christina Alexandra Schulz, Gunnar Engström, Anders Christensson, Peter M. Nilsson, Olle Melander, et al.
(2019) Kidney International Reports, 4 p.1143-1151
Journal articleBiomarkers of blood cadmium and incidence of cardiovascular events in non-smokers : Results from a population-based proteomics study
Yan Borné, Björn Fagerberg, Gerd Sallsten, Bo Hedblad, Margaretha Persson, et al.
(2019) Clinical Proteomics, 16
Journal articleSoluble TRAIL-R2 a marker of plaque cell apoptosis and cardiovascular events.
Isabel Goncalves, Pratibha Singh, Christoffer Tengryd, Michele Cavalera, Ingrid Yao Mattisson, et al.
(2019) Stroke: a journal of cerebral circulation, 50 p.1989-1996
Journal articlePhenotypic and genotypic differences between Indian and Scandinavian women with gestational diabetes mellitus
Geeti P Arora, Mikael Åkerlund, Charlotte Brøns, Gunn-Helen Moen, Niko S Wasenius, et al.
(2019) Journal of Internal Medicine, 286 p.192-206
Journal articleComplement C3 and incident hospitalization due to chronic kidney disease : a population-based cohort study
Xue Bao, Yan Borné, Iram Faqir Muhammad, Christina Alexandra Schulz, Margaretha Persson, et al.
(2019) BMC Nephrology, 20
Journal articleHigh Levels of Soluble Lectinlike Oxidized Low-Density Lipoprotein Receptor-1 Are Associated With Carotid Plaque Inflammation and Increased Risk of Ischemic Stroke
Hanna Markstad, Andreas Edsfeldt, Ingrid Yao Mattison, Eva Bengtsson, Pratibha Singh, et al.
(2019) Journal of the American Heart Association, 8
Journal articleA novel rare CUBN variant and three additional genes identified in Europeans with and without diabetes : results from an exome-wide association study of albuminuria
Tarunveer S. Ahluwalia, Christina Alexandra Schulz, Johannes Waage, Tea Skaaby, Niina Sandholm, et al.
(2019) Diabetologia, 62 p.292-305
Journal articleCardiometabolic Polygenic Risk Scores and Osteoarthritis Outcomes : A Mendelian Randomization Study Using Data From the Malmö Diet and Cancer Study and the UK Biobank
George Hindy, Kristina E. Åkesson, Olle Melander, Krishna G. Aragam, Mary E. Haas, et al.
(2019) Arthritis and Rheumatology, 71 p.925-934
Journal articleCommonly consumed beverages associate with different lifestyle and dietary intakes
Louise Brunkwall, Peter Almgren, Sophie Hellstrand, Marju Orho-Melander, Ulrika Ericson
(2019) International Journal of Food Sciences and Nutrition, 70 p.88-97
Journal articleFood patterns in relation to weight change and incidence of type 2 diabetes, coronary events and stroke in the Malmö Diet and Cancer cohort
Ulrika Ericson, Louise Brunkwall, Joana Alves Dias, Isabel Drake, Sophie Hellstrand, et al.
(2019) European Journal of Nutrition, 58 p.1801-1814
Journal articleHigh Plasma sRAGE (Soluble Receptor for Advanced Glycation End Products) Is Associated With Slower Carotid Intima-Media Thickness Progression and Lower Risk for First-Time Coronary Events and Mortality
Helena Grauen Larsen, Goran Marinkovic, Peter M. Nilsson, Jan Nilsson, Gunnar Engström, et al.
(2019) Arteriosclerosis, Thrombosis, and Vascular Biology, 39 p.925-933
Journal articleIncreased vascular endothelial growth factor D is associated with atrial fibrillation and ischaemic stroke
John Berntsson, J. Gustav Smith, Linda S.B. Johnson, Martin Söderholm, Yan Borné, et al.
(2019) Heart, 105 p.553-558
Journal articleGrowth differentiation factor 15 is positively associated with incidence of diabetes mellitus : the Malmö Diet and Cancer–Cardiovascular Cohort
Xue Bao, Yan Borné, Iram Faqir Muhammad, Jan Nilsson, Lars Lind, et al.
(2019) Diabetologia, 62 p.78-86
Journal articleErgothioneine is associated with reduced mortality and decreased risk of cardiovascular disease
Einar Smith, Filip Ottosson, Sophie Hellstrand, Ulrika Ericson, Marju Orho-Melander, et al.
(2019) Heart
Journal articleSubclinical atherosclerosis and its progression are modulated by PLIN2 through a feed-forward loop between LXR and autophagy
P. Saliba-Gustafsson, M. Pedrelli, K. Gertow, O. Werngren, V. Janas, et al.
(2019) Journal of Internal Medicine, 286 p.660-675
Journal articleCirculating Monocyte Chemoattractant Protein-1 and Risk of Stroke : Meta-Analysis of Population-Based Studies Involving 17 180 Individuals
Marios K. Georgakis, Rainer Malik, Harry Björkbacka, Tiberiu Alexandru Pana, Serkalem Demissie, et al.
(2019) Circulation Research, 125 p.773-782
Journal articleDimethylguanidino Valerate : A Lifestyle-Related Metabolite Associated With Future Coronary Artery Disease and Cardiovascular Mortality
Filip Ottosson, Ulrika Ericson, Peter Almgren, Einar Smith, Louise Brunkwall, et al.
(2019) Journal of the American Heart Association, 8
Journal articleAssociation of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study
Tao Huang, Ulrika Ericson, Emily Sonestedt, Christina-Alexandra Schulz, Marju Orho-Melander, et al.
(2019) JAMA Network Open, 2
Journal articlePlasma levels of the proprotein convertase furin and incidence of diabetes and mortality
C. Fernandez, J. Rysä, P. Almgren, J. Nilsson, G. Engström, et al.
(2018) Journal of Internal Medicine, 284 p.377-387
Journal articleMulti-ethnic genome-wide association study for atrial fibrillation
Carolina Roselli, Mark D. Chaffin, Lu Chen Weng, Stefanie Aeschbacher, Gustav Ahlberg, et al.
(2018) Nature Genetics, 50 p.1225-1233
Journal articleSaturated fat is more metabolically harmful for the human liver than unsaturated fat or simple sugars
Panu K. Luukkonen, Ashfaq Ali, Marju Orho-Melander, Hannele Yki-Järvinen
(2018) Diabetes Care, 41 p.1732-1739
Journal articleGenome-wide association study of coronary artery disease among individuals with diabetes : the UK Biobank
Tove Fall, Stefan Gustafsson, Marju Orho-Melander, Erik Ingelsson
(2018) Diabetologia, 61 p.2174-2179
Journal articleA Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes
Natalie R van Zuydam, Emma Ahlqvist, Claes Ladenvall, Peter Almgren, Christina-Alexandra Schulz, et al.
(2018) Diabetes, 67 p.1414-1427
Journal articleGenetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes
Viktoria Gusarova, Colm O'Dushlaine, Tanya M Teslovich, Peter N Benotti, Tooraj Mirshahi, et al.
(2018) Nature Communications, 9 p.1-11
Journal articleA Western dietary pattern is prospectively associated with cardio-metabolic traits and incidence of the metabolic syndrome
Isabel Drake, Emily Sonestedt, Ulrika Ericson, Peter Wallström, Marju Orho-Melander
(2018) British Journal of Nutrition, 119 p.1168-1176
Journal articleDietary and genetic risk scores and incidence of type 2 diabetes
Ulrika Ericson, George Hindy, Isabel Drake, Christina Alexandra Schulz, Louise Brunkwall, et al.
(2018) Genes and Nutrition, 13
Journal articleProneurotensin Predicts Cardiovascular Disease in an Elderly Population
Ayesha Fawad, Andreas Bergmann, Joachim Struck, Peter M. Nilsson, Marju Orho-Melander, et al.
(2018) Journal of Clinical Endocrinology and Metabolism, 103 p.1940-1947
Journal articleNeurotensin is a lipid-induced gastrointestinal peptide associated with visceral adipose tissue inflammation in obesity
Ilaria Barchetta, Flavia Agata Cimini, Danila Capoccia, Laura Bertoccini, Valentina Ceccarelli, et al.
(2018) Nutrients, 10
Journal articleConnection between BMI-Related Plasma Metabolite Profile and Gut Microbiota
Filip Ottosson, Louise Brunkwall, Ulrika Ericson, Peter M. Nilsson, Peter Almgren, et al.
(2018) Journal of Clinical Endocrinology and Metabolism, 103 p.1491-1501
Journal articlePlasma concentration of Caspase-8 is associated with short sleep duration and the risk of incident diabetes mellitus
Thomas Svensson, Akiko Kishi Svensson, Mariusz Kitlinski, Peter Almgren, Gunnar Engström, et al.
(2018) The Journal of clinical endocrinology and metabolism, 103 p.1592-1600
Journal articleRole of blood lipids in the development of ischemic stroke and its subtypes : A mendelian randomization study
George Hindy, Gunnar Engström, Susanna C. Larsson, Matthew Traylor, Hugh S. Markus, et al.
(2018) Stroke, 49 p.820-827
Journal articleBlood lipid genetic scores, the HMGCR gene and cancer risk : A Mendelian randomization study
Marju Orho-Melander, George Hindy, Signe Borgquist, Christina Alexandra Schulz, Jonas Manjer, et al.
(2018) International Journal of Epidemiology, 47 p.495-505
Journal articleAssociation between systemic leptin and neurotensin concentration in adult individuals with and without type 2 diabetes mellitus
I. Barchetta, G. Ciccarelli, F. A. Cimini, V. Ceccarelli, M. Orho-Melander, et al.
(2018) Journal of Endocrinological Investigation, 41 p.1159-1163
Journal articleVascular Endothelial Growth Factor D, Pulmonary Congestion, and Incidence of Heart Failure
Yan Borné, Klas Gränsbo, Jan Nilsson, Olle Melander, Marju Orho-Melander, et al.
(2018) Journal of the American College of Cardiology, 71 p.580-582
Journal article (letter)Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent
Caren E. Smith, Jack L. Follis, Hassan S. Dashti, Toshiko Tanaka, Mariaelisa Graff, et al.
(2018) Molecular Nutrition & Food Research, 62
Journal articleSugar-sweetened beverage intake associations with fasting glucose and insulin concentrations are not modified by selected genetic variants in a ChREBP-FGF21 pathway : a meta-analysis
Nicola M. McKeown, Hassan S. Dashti, Jiantao Ma, Danielle E. Haslam, Jessica C. Kiefte-de Jong, et al.
(2018) Diabetologia, 61 p.317-330
Journal articleRefining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes article
Anubha Mahajan, Jennifer Wessel, Sara M Willems, Wei Zhao, Neil R Robertson, et al.
(2018) Nature Genetics, 50 p.559-571
Journal articleAdiposity and genetic factors in relation to triglycerides and triglyceride-rich lipoproteins in the women's genome health study
Shafqat Ahmad, Samia Mora, Paul W. Franks, Marju Orho-Melander, Paul M. Ridker, et al.
(2018) Clinical Chemistry, 64 p.231-241
Journal articleFADD (Fas-Associated Protein With Death Domain), Caspase-3, and Caspase-8 and Incidence of Ischemic Stroke
Iram Faqir Muhammad, Yan Borné, Olle Melander, Marju Orho-Melander, Jan Nilsson, et al.
(2018) Stroke, 49 p.2224-2226
Journal articlePolygenic Risk Score for Coronary Heart Disease Modifies the Elevated Risk by Cigarette Smoking for Disease Incidence
George Hindy, Frans Wiberg, Peter Almgren, Olle Melander, Marju Orho-Melander
(2018) Circulation: Genomic and Precision Medicine, 11
Journal articleRisk of bladder cancer by disease severity in relation to metabolic factors and smoking : A prospective pooled cohort study of 800,000 men and women
Stanley Teleka, Christel Häggström, Gabriele Nagel, Tone Bjørge, Jonas Manjer, et al.
(2018) International Journal of Cancer, 143 p.3071-3082
Journal articleA genetic risk score for fasting plasma glucose is independently associatedwith arterial stiffness : A Mendelian randomization study
Mikael Gottsäter, George Hindy, Marju Orho-Melander, Peter M. Nilsson, Olle Melander
(2018) Journal of Hypertension, 36 p.809-814
Journal articleADAMTS-7 is associated with a high-risk plaque phenotype in human atherosclerosis
Eva Bengtsson, Karin Hultman, Pontus Dunér, Giuseppe Asciutto, Peter Almgren, et al.
(2017) Scientific Reports, 7
Journal articleElevated Markers of Death Receptor-Activated Apoptosis are Associated with Increased Risk for Development of Diabetes and Cardiovascular Disease
Ingrid Yao Mattisson, Harry Björkbacka, Maria Wigren, Andreas Edsfeldt, Olle Melander, et al.
(2017) EBioMedicine, 26 p.187-197
Journal articlePredictors of Liver Fat and Stiffness in Non-Alcoholic Fatty Liver Disease (NAFLD) - An 11-Year Prospective Study
Susanna Lallukka, Sanja Sädevirta, Markus T. Kallio, Panu K. Luukkonen, You Zhou, et al.
(2017) Scientific Reports, 7
Journal articleGenetic determinants of circulating GIP and GLP-1 concentrations
Peter Almgren, Andreas Lindqvist, Ulrika Krus, Liisa H. Hakaste, Emilia Ottosson Laakso, et al.
(2017) JCI Insight, 2
Journal articleA prospective study of dietary and supplemental zinc intake and risk of type 2 diabetes depending on genetic variation in SLC30A8
Isabel Drake, George Hindy, Ulrika Ericson, Marju Orho-Melander
(2017) Genes and Nutrition, 12
Journal articleEosinophil Cationic Protein, Carotid Plaque, and Incidence of Stroke
Johannes Sundström, Martin Söderholm, Yan Borné, Jan Nilsson, Margaretha Persson, et al.
(2017) Stroke, 48 p.2686-2692
Journal articleType 2 diabetes, adiposity and cancer morbidity and mortality risk taking into account competing risk of noncancer deaths in a prospective cohort setting
Isabel Drake, Bo Gullberg, Emily Sonestedt, Tanja Stocks, Anders Bjartell, et al.
(2017) International Journal of Cancer, 141 p.1170-1180
Journal articlePlasma stem cell factor levels are associated with risk of cardiovascular disease and death
H Björkbacka, I Yao Mattisson, M Wigren, O Melander, G. N. Fredrikson, et al.
(2017) Journal of Internal Medicine, 282 p.508-521
Journal articleType 2 diabetes, glucose, insulin, BMI, and ischemic stroke subtypes : Mendelian randomization study
Susanna C. Larsson, Robert A. Scott, Matthew Traylor, Claudia Langenberg, George Hindy, et al.
(2017) Neurology, 89 p.454-460
Journal articleDietary starch intake modifies the relation between copy number variation in the salivary amylase gene and BMI
Gull Rukh, Ulrika Ericson, Johanna Andersson-Assarsson, Marju Orho-Melander, Emily Sonestedt
(2017) American Journal of Clinical Nutrition, 106 p.256-262
Journal articleImpaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD
Panu K. Luukkonen, You Zhou, P. A. Nidhina Haridas, Om P. Dwivedi, Tuulia Hyötyläinen, et al.
(2017) Journal of Hepatology, 67 p.128-136
Journal articleThe gut microbiome as a target for prevention and treatment of hyperglycaemia in type 2 diabetes: from current human evidence to future possibilities
Louise Brunkwall, Marju Orho-Melander
(2017) Diabetologia, 60 p.943-951
Journal article reviewSOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function
Man Li, Yong Li, Olivia Weeks, Vladan Mijatovic, Alexander Teumer, et al.
(2017) Journal of the American Society of Nephrology: JASN, 28 p.981-994
Journal articleSoluble Urokinase-type Plasminogen Activator Receptor (suPAR) and Impaired Kidney Function in the Population-based Malmö Diet and Cancer Study
Christina-Alexandra Schulz, Margaretha Persson, Anders Christensson, George Hindy, Peter Almgren, et al.
(2017) Kidney International Reports, 2 p.239-247
Journal articleSystematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease
Thomas R. Webb, Jeanette Erdmann, Kathleen E. Stirrups, Nathan O. Stitziel, Nicholas G D Masca, et al.
(2017) Journal of the American College of Cardiology, 69 p.823-836
Journal articleHigh Level of Fasting Plasma Proenkephalin-A Predicts Deterioration of Kidney Function and Incidence of CKD
Christina-Alexandra Schulz, Anders Christensson, Ulrika Ericson, Peter Almgren, George Hindy, et al.
(2017) Journal of the American Society of Nephrology: JASN, 28 p.291-303
Journal articleObesity/insulin resistance rather than liver fat increases coagulation factor activities and expression in humans
Susanna Lallukka, Panu K. Luukkonen, You Zhou, Elina Isokuortti, Marja Leivonen, et al.
(2017) Thrombosis and Haemostasis, 117 p.286-294
Journal articleNovel genetic loci associated with long-term deterioration in blood lipid concentrations and coronary artery disease in European adults
Tibor V. Varga, Azra Kurbasic, Mattias Aine, Pontus Eriksson, Ashfaq Ali, et al.
(2017) International Journal of Epidemiology, 46 p.1211-1222
Journal articleData Descriptor: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls
Jason Flannick, Christian Fuchsberger, Anubha Mahajan, Tanya M Teslovich, Vineeta Agarwala, et al.
(2017) Scientific Data, 4
Journal articleExome-wide association study of plasma lipids in >300,000 individuals
Dajiang J Liu, Gina M. Peloso, Haojie Yu, Adam S. Butterworth, Anubha Mahajan, et al.
(2017) Nature Genetics, 49 p.1758-1766
Journal articleIdentification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease
Wei Zhao, Asif Rasheed, Emmi Tikkanen, Jung-Jin Lee, Adam S. Butterworth, et al.
(2017) Nature Genetics, 49 p.1450-1457
Journal articleA low-frequency inactivating AKT2 variant enriched in the finnish population is associated with fasting insulin levels and type 2 diabetes risk
Alisa Manning, Claes Ladenvall, Peter Nilsson, Tibor V. Varga, Paul Franks, et al.
(2017) Diabetes, 66 p.2019-2032
Journal articleHigher levels of serum zonulin may rather be associated with increased risk of obesity and hyperlipidemia, than wih gastrointestinal symptoms or disease manifestaiton
Bodil Ohlsson, Marju Orho-Melander, Peter Nilsson
(2017) International Journal of Molecular Sciences, 18
Journal articleGenetic risk, adherence to a healthy lifestyle, and coronary disease
Amit V. Khera, Connor A. Emdin, Isabel Drake, Pradeep Natarajan, Alexander G. Bick, et al.
(2016) New England Journal of Medicine, 375 p.2349-2358
Journal articleThe MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humans
Panu K. Luukkonen, You Zhou, Tuulia Hyötyläinen, Marja Leivonen, Johanna Arola, et al.
(2016) Journal of Hepatology, 65 p.1263-1265
Journal article (letter)Sugar-sweetened beverage consumption and genetic predisposition to obesity in 2 Swedish cohorts
Louise Brunkwall, Yan Chen, George Hindy, Gull Rukh, Ulrika Ericson, et al.
(2016) American Journal of Clinical Nutrition, 104 p.809-815
Journal articleIntegrator of stress responses calmodulin binding transcription activator 1 (Camta1) Regulates miR-212/miR-132 Expression and insulin secretion
Inês Guerra Uerra Mollet, Helena Anna Malm, Anna Wendt, Marju Orho-Melander, Lena Eliasson
(2016) Journal of Biological Chemistry, 291 p.18440-18452
Journal articleInteraction between rs10830963 polymorphism in MTNR1B and lifestyle intervention on occurrence of gestational diabetes
Nora E. Grotenfelt, Niko S. Wasenius, Kristiina Rönö, Hannele Laivuori, Beata Stach-Lempinen, et al.
(2016) Diabetologia, 59 p.1655-1658
Journal articleExcess maternal transmission of variants in the THADA gene to offspring with type 2 diabetes
Rashmi B. Prasad, Anna Lessmark, Peter Almgren, Györgyi Kovacs, Ola Hansson, et al.
(2016) Diabetologia, 59 p.1702-1713
Journal articleExome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits
Nathalie Chami, Ming Huei Chen, Andrew J. Slater, John D. Eicher, Evangelos Evangelou, et al.
(2016) American Journal of Human Genetics, 99 p.8-21
Journal articleA high diet quality based on dietary recommendations is not associated with lower incidence of type 2 diabetes in the malmö diet and cancer cohort
Emmanuel Mandalazi, Isabel Drake, Elisabet Wirfält, Marju Orho-Melander, Emily Sonestedt
(2016) International Journal of Molecular Sciences, 17
Journal articleAn obligatory role for neurotensin in high-fat-diet-induced obesity
Jing Li, Jun S. Song, Yekaterina Y. Zaytseva, Yajuan Liu, Piotr Rychahou, et al.
(2016) Nature, 533 p.411-415
Journal article (letter)Diet quality and change in blood lipids during 16 years of follow-up and their interaction with genetic risk for dyslipidemia
Emily Sonestedt, Sophie Hellstrand, Isabel Drake, Christina Alexandra Schulz, Ulrika Ericson, et al.
(2016) Nutrients, 8
Journal articleCoding variation in ANGPTL4, LPL, and SVEP1 and the risk of coronary disease
Nathan O. Stitziel, Kathleen E. Stirrups, Nicholas G D Masca, Jeanette Erdmann, Paola G. Ferrario, et al.
(2016) New England Journal of Medicine, 374 p.1134-1144
Journal articleDo Genetic Factors Modify the Relationship Between Obesity and Hypertriglyceridemia? : Findings From the GLACIER and the MDC Studies
Ashfaq Ali, Tibor V Varga, Ivana Stojkovic, Christina-Alexandra Schulz, Göran Hallmans, et al.
(2016) Circulation: Cardiovascular Genetics, 9 p.162-171
Journal articleApo-lipoproteins, lipids and risk of cancer.
Signe Borgquist, Talha Butt, Peter Almgren, Dov Shiffman, Tanja Stocks, et al.
(2016) International Journal of Cancer, 138 p.2648-2656
Journal articleTranscriptional regulation of the miR-212/miR-132 cluster in insulin-secreting β-cells by cAMP-regulated transcriptional co-activator 1 and salt-inducible kinases.
Helena Malm, Ines Mollet, Christine Berggreen, Marju Orho-Melander, Jonathan Esguerra, et al.
(2016) Molecular and Cellular Endocrinology, 424 p.23-33
Journal articleGCKR : How genetic variation across the allelic spectrum influences protein function and metabolic traits in humans
Marju Orho-Melander, Anna L. Gloyn
(2016) The Genetics of Type 2 Diabetes and Related Traits: Biology, Physiology and Translation , p.317-336
Book chapterGlucose-Dependent Insulinotropic Polypeptide (GIP) Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB.
Lisa Berglund, Valeriya Lyssenko, Claes Ladenvall, Olga Kotova, Andreas Edsfeldt, et al.
(2016) Diabetes, 65 p.239-254
Journal articleProinflammatory Role of Sphingolipids and Glycosphingolipids in the Human Atherosclerotic Plaque
Andreas Edsfeldt, Pontus Dunér, Marcus Ståhlman, Ines G Mollet, Giuseppe Asciutto, et al.
(2016) Arteriosclerosis, Thrombosis and Vascular Biology, 36 p.1132-1140
Journal articleAssociation of Lipid-Related Genetic Variants with the Incidence of Atrial Fibrillation : The AFGen Consortium
Faye L Norby, Samuel Adamsson Eryd, Maartje N Niemeijer, Lynda M Rose, Albert V Smith, et al.
(2016) PLoS ONE, 11
Journal articleGenetic susceptibility to dyslipidemia and incidence of cardiovascular disease depending on a diet quality index in the Malmö diet and cancer cohort
Sophie Hellstrand, Ulrika Ericson, Christina Alexandra Schulz, Isabel Drake, Bo Gullberg, et al.
(2016) Genes & Nutrition, 11
Journal articleSeveral type 2 diabetes-associated variants in genes annotated to WNT signaling interact with dietary fiber in relation to incidence of type 2 diabetes
George Hindy, Ines Mollet, Gull Rukh, Ulrika Ericson, Marju Orho-Melander
(2016) Genes & Nutrition, 11
Journal articleHälsosam livsstil kompenserar för genetisk risk för hjärtsjukdom
Isabel Drake, Olle Melander, Marju Orho-Melander
(2016) Läkartidningen, 113
Journal articleInverse relationship between a genetic risk score of 31 BMI loci and weight change before and after reaching middle age.
Gull Rukh, Shafqat Ahmad, Ulrika Ericson, George Hindy, Tanja Stocks, et al.
(2015) International Journal of Obesity
Journal articleThe Association between Carbohydrate-Rich Foods and Risk of Cardiovascular Disease Is Not Modified by Genetic Susceptibility to Dyslipidemia as Determined by 80 Validated Variants.
Emily Sonestedt, Sophie Hellstrand, Christina-Alexandra Schulz, Peter Wallström, Isabel Drake, et al.
(2015) PLoS ONE, 10
Journal articleIntakes of omega-3 polyunsaturated fatty acids and blood pressure change over time: Possible interaction with genes involved in 20-HETE and EETs metabolism.
Angela Tagetti, Ulrika Ericson, Martina Montagnana, Elisa Danese, Peter Almgren, et al.
(2015) Prostaglandins & other Lipid Mediators, 120 p.126-133
Journal articleLiver Fat Content and Hepatic Insulin Sensitivity in Overweight Patients With Type 1 Diabetes
Gemma Llaurado, Ksenia Sevastianova, Sanja Sadevirta, Antti Hakkarainen, Nina Lundbom, et al.
(2015) Journal of Clinical Endocrinology and Metabolism, 100 p.607-616
Journal articleUsing genetics to test the causal relationship of total adiposity and periodontitis: Mendelian randomization analyses in the Gene-Lifestyle Interactions and Dental Endpoints (GLIDE) Consortium.
Dmitry Shungin, Marilyn C Cornelis, Kimon Divaris, Birte Holtfreter, John R Shaffer, et al.
(2015) International Journal of Epidemiology, 44 p.638-650
Journal articleCirculating triacylglycerol signatures and insulin sensitivity in NAFLD associated with the E167K variant in TM6SF2
You Zhou, Gemma Llaurado, Matej Oresic, Tuulia Hyotylainen, Marju Orho-Melander, et al.
(2015) Journal of Hepatology, 62 p.657-663
Journal articleStable Peptide of the Endogenous Opioid Enkephalin Precursor and Breast Cancer Risk.
Olle Melander, Marju Orho-Melander, Jonas Manjer, Thomas Svensson, Peter Almgren, et al.
(2015) Journal of Clinical Oncology, 33 p.81-2632
Journal articleConsumption of meat is associated with higher fasting glucose and insulin concentrations regardless of glucose and insulin genetic risk scores: a meta-analysis of 50,345 Caucasians.
Amanda M Fretts, Jack L Follis, Jennifer A Nettleton, Rozenn N Lemaitre, Julius S Ngwa, et al.
(2015) American Journal of Clinical Nutrition, 102 p.1266-1278
Journal articleFood sources of fat may clarify the inconsistent role of dietary fat intake for incidence of type 2 diabetes.
Ulrika Ericson, Sophie Hellstrand, Louise Brunkwall, Christina-Alexandra Schulz, Emily Sonestedt, et al.
(2015) American Journal of Clinical Nutrition, 101 p.1065-1080
Journal articleGenetics of coronary heart disease: towards causal mechanisms, novel drug targets and more personalized prevention.
Marju Orho-Melander
(2015) Journal of Internal Medicine, 278 p.433-446
Journal article reviewGene×dietary pattern interactions in obesity: analysis of up to 68,317 adults of European ancestry.
Jennifer A Nettleton, Jack L Follis, Julius S Ngwa, Caren E Smith, Shafqat Ahmad, et al.
(2015) Human Molecular Genetics, 24 p.4728-4738
Journal article1C.07: PRONEUROTENSIN INDEPENDENTLY PREDICTS CARDIOVASCULAR DISEASE. THE MALMÖ PREVENTIVE PROJECT.
Ayesha Fawad, C Schultz, P M Nilsson, Marju Orho-Melander, Olle Melander
(2015) Journal of Hypertension, 33 Suppl 1 p.11-11
Journal articleSmoking modifies the associated increased risk of future cardiovascular disease by genetic variation on chromosome 9p21.
Viktor Hamrefors, Bo Hedblad, George Hindy, Gustav Smith, Peter Almgren, et al.
(2014) PLoS ONE, 9
Journal articleLoss-of-Function Mutations in APOC3, Triglycerides, and Coronary Disease
Jacy Crosby, Gina M. Peloso, Paul L. Auer, David R. Crosslin, Nathan O. Stitziel, et al.
(2014) New England Journal of Medicine, 371 p.22-31
Journal articleA population-based study on the prevalence of NASH using scores validated against liver histology.
Jenni Hyysalo, Ville T Männistö, You Zhou, Johanna Arola, Vesa Kärjä, et al.
(2014) Journal of Hepatology, 60 p.839-846
Journal articleTCF7L2 type 2 diabetes risk variant, lifestyle factors, and incidence of prostate cancer.
Isabel Drake, Peter Wallström, George Hindy, Ulrika Ericson, Bo Gullberg, et al.
(2014) The Prostate, 74 p.1161-1170
Journal articleVariability in the CIITA gene interacts with HLA in multiple sclerosis.
A Gyllenberg, F Piehl, L Alfredsson, J Hillert, I L Bomfim, et al.
(2014) Genes and Immunity, 15 p.162-167
Journal articleDiabetes mellitus and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition
Konstantinos K. Tsilidis, Naomi E. Allen, Paul N. Appleby, Sabine Rohrmann, Ute Noethlings, et al.
(2014) International Journal of Cancer, 136 p.372-381
Journal articleAssociation of Low-Density Lipoprotein Cholesterol-Related Genetic Variants With Aortic Valve Calcium and Incident Aortic Stenosis.
Gustav Smith, Kevin Luk, Christina-Alexandra Schulz, James C Engert, Ron Do, et al.
(2014) JAMA: The Journal of the American Medical Association, 312 p.1764-1771
Journal articleFTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals.
Qibin Qi, Tuomas O Kilpeläinen, Mary K Downer, Toshiko Tanaka, Caren E Smith, et al.
(2014) Human Molecular Genetics, 23 p.6961-6972
Journal articleImpaired Fibrous Repair: A Possible Contributor to Atherosclerotic Plaque Vulnerability in Patients With Type II Diabetes.
Andreas Edsfeldt, Isabel Goncalves, Helena Grufman, Mihaela Nitulescu, Pontus Dunér, et al.
(2014) Arteriosclerosis, Thrombosis and Vascular Biology, 34 p.2143-2150
Journal articleAssociation of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks.
Gina M Peloso, Paul L Auer, Joshua C Bis, Arend Voorman, Alanna C Morrison, et al.
(2014) American Journal of Human Genetics, 94 p.223-232
Journal articleLifestyle factors and mortality risk in individuals with diabetes mellitus: are the associations different from those in individuals without diabetes?
Diewertje Sluik, Heiner Boeing, Kuanrong Li, Rudolf Kaaks, Nina Fons Johnsen, et al.
(2014) Diabetologia, 57 p.63-72
Journal articleValidation of plasma proneurotensin as a novel biomarker for the prediction of incident breast cancer.
Olle Melander, Mattias Belting, Jonas Manjer, Alan S Maisel, Bo Hedblad, et al.
(2014) Cancer Epidemiology Biomarkers & Prevention, 23 p.1672-1676
Journal articleGenetic Determinants of Long-Term Changes in Blood Lipid Concentrations: 10-Year Follow-Up of the GLACIER Study.
Tibor V Varga, Emily Sonestedt, Dmitry Shungin, Robert Koivula, Göran Hallmans, et al.
(2014) PLoS Genetics, 10
Journal articleMeta-analysis of gene-level tests for rare variant association.
Dajiang J Liu, Gina M Peloso, Xiaowei Zhan, Oddgeir L Holmen, Matthew Zawistowski, et al.
(2014) Nature Genetics, 46 p.200-200
Journal articleGenetic Variation in FADS Has Little Effect on the Association between Dietary PUFA Intake and Cardiovascular Disease.
Sophie Hellstrand, Ulrika Ericson, Bo Gullberg, Bo Hedblad, Marju Orho-Melander, et al.
(2014) Journal of Nutrition, 144 p.1356-1363
Journal articleThe PNPLA3 Ile148Met interacts with overweight and dietary intakes on fasting triglyceride levels.
Ivana Stojkovic, Ulrika Ericson, Gull Rukh, Martin Riddestråle, Stefano Romeo, et al.
(2014) Genes & Nutrition, 9 p.388-388
Journal articleThe chromosome 9p21 variant interacts with vegetable and wine intake to influence the risk of cardiovascular disease : a population based cohort study
George Hindy, Ulrika Ericson, Viktor Hamrefors, Isabel Drake, Elisabet Wirfält, et al.
(2014) BMC Medical Genetics, 15
Journal articleGenetic variation in the fat mass and obesity-associated gene (FTO) in association with food preferences in healthy adults.
Louise Brunkwall, Ulrika Ericson, Sophie Hellstrand, Bo Gullberg, Marju Orho-Melander, et al.
(2013) Food & Nutrition Research, 57
Journal articleThe Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis
Tove Fall, Sara Hagg, Reedik Maegi, Alexander Ploner, Krista Fischer, et al.
(2013) PLoS Medicine, 10
Journal articleHigh intakes of protein and processed meat associate with increased incidence of type 2 diabetes.
Ulrika Ericson, Emily Sonestedt, Bo Gullberg, Sophie Hellstrand, George Hindy, et al.
(2013) British Journal of Nutrition, 109 p.1143-1153
Journal articleNetwork-based Analysis of Genome Wide Association Data Provides Novel Candidate Genes for Lipid and Lipoprotein Traits
Amitabh Sharma, Natali Gulbahce, Samuel J. Pevzner, Joerg Menche, Claes Ladenvall, et al.
(2013) Molecular & Cellular Proteomics, 12 p.3398-3408
Journal articleAdipose tissue is inflamed in NAFLD due to obesity but not in NAFLD due to genetic variation in PNPLA3
S. Lallukka, K. Sevastianova, J. Perttila, A. Hakkarainen, Marju Orho-Melander, et al.
(2013) Diabetologia, 56 p.886-892
Journal articleGenetic susceptibility to obesity and diet intakes: association and interaction analyses in the Malmö Diet and Cancer Study.
Gull Rukh, Emily Sonestedt, Olle Melander, Bo Hedblad, Elisabet Wirfält, et al.
(2013) Genes & Nutrition, 8 p.535-547
Journal articleA diabetes-predictive amino acid score and future cardiovascular disease.
Martin Magnusson, Gregory D Lewis, Ulrika Ericson, Marju Orho-Melander, Bo Hedblad, et al.
(2013) European Heart Journal, 34 p.1982-1989
Journal articleExome Sequencing and Directed Clinical Phenotyping Diagnose Cholesterol Ester Storage Disease Presenting as Autosomal Recessive Hypercholesterolemia.
Nathan O Stitziel, Sigrid W Fouchier, Barbara Sjouke, Gina M Peloso, Alessa M Moscoso, et al.
(2013) Arteriosclerosis, Thrombosis and Vascular Biology, 33 p.2909-2914
Journal articleThe IRS1 rs2943641 Variant and Risk of Future Cancer Among Morbidly Obese Individuals.
Cristina Maglio, Ulrika Ericson, Maria Antonella Burza, Rosellina Margherita Mancina, Carlo Pirazzi, et al.
(2013) Journal of Clinical Endocrinology and Metabolism, 98 p.785-789
Journal articleGene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry. : combined analysis of 111,421 individuals of European ancestry
Shafqat Ahmad, Gull Rukh, Tibor V Varga, Ashfaq Ali, Azra Kurbasic, et al.
(2013) PLoS Genetics, 9 p.1003607-1003607
Journal articleAdipocyte Size is Associated with NAFLD Independent of Obesity, Fat Distribution, and PNPLA3 Genotype
Elina M. Petaja, Ksenia Sevastianova, Antti Hakkarainen, Marju Orho-Melander, Nina Lundbom, et al.
(2013) Obesity, 21 p.1174-1179
Journal articleHigher Magnesium Intake Is Associated with Lower Fasting Glucose and Insulin, with No Evidence of Interaction with Select Genetic Loci, in a Meta-Analysis of 15 CHARGE Consortium Studies
Adela Hruby, Julius S. Ngwa, Frida Renström, Mary K. Wojczynski, Andrea Ganna, et al.
(2013) Journal of Nutrition, 143 p.345-353
Journal articleMeta-Analysis Investigating Associations Between Healthy Diet and Fasting Glucose and Insulin Levels and Modification by Loci Associated With Glucose Homeostasis in Data From 15 Cohorts
Jennifer A. Nettleton, Marie-France Hivert, Rozenn N. Lemaitre, Nicola M. McKeown, Dariush Mozaffarian, et al.
(2013) American Journal of Epidemiology, 177 p.103-115
Journal article reviewGenome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake
Toshiko Tanaka, Julius S. Ngwa, Frank J. A. van Rooij, M. Carola Zillikens, Mary K. Wojczynski, et al.
(2013) American Journal of Clinical Nutrition, 97 p.1395-1402
Journal articleGenetic Variation in SULF2 Is Associated with Postprandial Clearance of Triglyceride-Rich Remnant Particles and Triglyceride Levels in Healthy Subjects
Niina Matikainen, Maria Antonella Burza, Stefano Romeo, Antti Hakkarainen, Martin Adiels, et al.
(2013) PLoS ONE, 8
Journal articleSex-specific interactions between the IRS1 polymorphism and intakes of carbohydrates and fat on incident type 2 diabetes.
Ulrika Ericson, Gull Rukh, Ivana Stojkovic, Emily Sonestedt, Bo Gullberg, et al.
(2012) The American journal of clinical nutrition
Journal articleDietary Fiber, Carbohydrate Quality and Quantity, and Mortality Risk of Individuals with Diabetes Mellitus
Koert N. J. Burger, Joline W. J. Beulens, Yvonne T. van der Schouw, Ivonne Sluijs, Annemieke M. W. Spijkerman, et al.
(2012) PLoS ONE, 7
Journal articleGenetic variation in PNPLA3 but not APOC3 influences liver fat in non-alcoholic fatty liver disease
Jenni Hyysalo, Ivana Stojkovic, Anna Kotronen, Antti Hakkarainen, Ksenia Sevastianova, et al.
(2012) Journal of Gastroenterology and Hepatology, 27 p.951-956
Journal articleRole of TCF7L2 risk variant and dietary fibre intake on incident type 2 diabetes.
George Hindy, Emily Sonestedt, Ulrika Ericson, X-J Jing, Yuedan Zhou, et al.
(2012) Diabetologia, 55 p.2646-2654
Journal articlePatatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitro
Carlo Pirazzi, Martin Adiels, Maria Antonella Burza, Rosellina Margherita Mancina, Malin Levin, et al.
(2012) Journal of Hepatology, 57 p.1276-1282
Journal articleIntake levels of dietary long-chain PUFAs modify the association between genetic variation in FADS and LDL-C
Sophie Hellstrand, Emily Sonestedt, Ulrika Ericson, Bo Gullberg, Elisabet Wirfält, et al.
(2012) Journal of Lipid Research, 53 p.1183-1189
Journal articlePlasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
Benjamin F. Voight, Gina M. Peloso, Marju Orho-Melander, Ruth Frikke-Schmidt, Maja Barbalic, et al.
(2012) The Lancet, 380 p.572-580
Journal articleAge-dependent variation of genotypes in MHC II transactivator gene (CIITA) in controls and association to type 1 diabetes
A Gyllenberg, Samina Asad, F Piehl, Maria Swanberg, L Padyukov, et al.
(2012) Genes and Immunity, 13 p.632-640
Journal articleHigh disaccharide intake associates with atherogenic lipoprotein profile.
Emily Sonestedt, Elisabet Wirfält, Peter Wallström, Bo Gullberg, Isabel Drake, et al.
(2012) British Journal of Nutrition, 107 p.1062-1069
Journal articlePlasma proneurotensin and incidence of diabetes, cardiovascular disease, breast cancer, and mortality.
Olle Melander, Alan S Maisel, Peter Almgren, Jonas Manjer, Mattias Belting, et al.
(2012) JAMA: The Journal of the American Medical Association, 308 p.1469-1475
Journal articleGenetic Variation in the Glucose-Dependent Insulinotropic Polypeptide Receptor Modifies the Association between Carbohydrate and Fat Intake and Risk of Type 2 Diabetes in the Malmo Diet and Cancer Cohort.
Emily Sonestedt, Valeriya Lyssenko, Ulrika Ericson, Bo Gullberg, Elisabet Wirfält, et al.
(2012) The Journal of clinical endocrinology and metabolism, 97 p.810-818
Journal articleNyheter inom kardiovaskulär genetik öppnar för nya terapimöjligheter
Peter M. Nilsson, Marju Orho-Melander, Olle Melander
(2011) Läkartidningen, 108 p.540-543
Journal articleFTO, Type 2 Diabetes, and Weight Gain Throughout Adult Life A Meta-Analysis of 41,504 Subjects From the Scandinavian HUNT, MDC, and MPP Studies
Jens K. Hertel, Stefan Johansson, Emily Sonestedt, Anna Jonsson, Rolv T. Lie, et al.
(2011) Diabetes, 60 p.1637-1644
Journal articleTotal Zinc Intake May Modify the Glucose-Raising Effect of a Zinc Transporter (SLC30A8) Variant A 14-Cohort Meta-analysis
Stavroula Kanoni, Jennifer A. Nettleton, Marie-France Hivert, Zheng Ye, Frank J. A. van Rooij, et al.
(2011) Diabetes, 60 p.2407-2416
Journal articleDairy products and its association with incidence of cardiovascular disease: the Malmö diet and cancer cohort.
Emily Sonestedt, Elisabet Wirfält, Peter Wallström, Bo Gullberg, Marju Orho-Melander, et al.
(2011) European Journal of Epidemiology, 26 p.609-618
Journal articleAssociation between fat intake, physical activity and mortality depending on genetic variation in FTO.
Emily Sonestedt, Bo Gullberg, Ulrika Ericson, Elisabet Wirfält, Bo Hedblad, et al.
(2011) International Journal of Obesity, 35 p.1041-1049
Journal articleThe mouse QTL map helps interpret human genome-wide association studies for HDL cholesterol
Magalie S. Leduc, Malcolm Lyons, Katayoon Darvishi, Kenneth Walsh, Susan Sheehan, et al.
(2011) Journal of Lipid Research, 52 p.1139-1149
Journal articlePhysical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children
Tuomas O. Kilpelaeinen, Lu Qi, Soren Brage, Stephen J. Sharp, Emily Sonestedt, et al.
(2011) PLoS Medicine, 8
Journal articleDual Metabolic Defects Are Required to Produce Hypertriglyceridemia in Obese Subjects
Marja-Riitta Taskinen, Martin Adiels, Jukka Westerbacka, Sanni Soderlund, Juhani Kahri, et al.
(2011) Arteriosclerosis, Thrombosis and Vascular Biology, 31 p.556-2144
Journal articleTesting for an Unusual Distribution of Rare Variants
Benjamin M. Neale, Manuel A. Rivas, Benjamin F. Voight, David Altshuler, Bernie Devlin, et al.
(2011) PLoS Genetics, 7
Journal articleGenetic variation in PNPLA3 (adiponutrin) confers sensitivity to weight loss-induced decrease in liver fat in humans
Ksenia Sevastianova, Anna Kotronen, Amalia Gastaldelli, Julia Perttila, Antti Hakkarainen, et al.
(2011) American Journal of Clinical Nutrition, 94 p.104-111
Journal articlePleiotropic Effects of GIP on Islet Function Involve Osteopontin
Valeriya Lyssenko, Lena Eliasson, Olga Kotova, Kasper Pilgaard, Nils Wierup, et al.
(2011) Diabetes, 60 p.2424-2433
Journal articleTesting for an unusual distribution of rare variation
Benjamin M. Neale, Manuel A. Rivas, Benjamin F. Voight, David Altshuler, Bernie Devlin, et al.
(2010) Behavior Genetics, 40 p.807-807
Conference paper: abstractHigh intake of fermented milk is associated with decreased risk of type 2 diabetes and better insulin sensitivity
Emily Sonestedt, Marju Orho-Melander
(2010) Diabetologia, 53 p.358-358
Conference paper: abstractInterpretation of genome wide association data for lipoprotein traits using systems biology approach
Amitabh Sharma, N. Gulbahce, Stefan Lang, Claes Ladenvall, S. Kathiresan, et al.
(2010) Diabetologia, 53 p.323-323
Conference paper: abstractDoes macronutrient intake or physical activity level interact with genetic risk for increased fasting glucose?
George Hindy, Emily Sonestedt, Amitabh Sharma, Marju Orho-Melander
(2010) Diabetologia, 53 p.313-313
Conference paper: abstractBiological, clinical and population relevance of 95 loci for blood lipids
Tanya M. Teslovich, Kiran Musunuru, Albert V. Smith, Andrew C. Edmondson, Ioannis M. Stylianou, et al.
(2010) Nature, 466 p.707-713
Journal articleFrom noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus
Kiran Musunuru, Alanna Strong, Maria Frank-Kamenetsky, Noemi E. Lee, Tim Ahfeldt, et al.
(2010) Nature, 466 p.2-714
Journal articleNiemann-Pick C1 Modulates Hepatic Triglyceride Metabolism and Its Genetic Variation Contributes to Serum Triglyceride Levels
Riikka-Liisa Uronen, Per Lundmark, Marju Orho-Melander, Matti Jauhiainen, Kristina Larsson, et al.
(2010) Arteriosclerosis, Thrombosis and Vascular Biology, 30 p.230-1614
Journal articleA gene score of nine LDL and HDL regulating genes is associated with fluvastatin induced cholesterol changes in women.
Viktor Hamrefors, Marju Orho-Melander, Ronald M Krauss, Bo Hedblad, Peter Almgren, et al.
(2010) Journal of Lipid Research, 51 p.625-634
Journal articleGenome wide association analysis for free fatty acid levels in DGI
Ivana Stojkovic, C. Saloranta, Peter Almgren, Valeriya Lyssenko, E. Laurila, et al.
(2010) Diabetologia, 53 p.322-322
Conference paper: abstractA multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses
Samuli Ripatti, Emmi Tikkanen, Marju Orho-Melander, Aki S. Havulinna, Kaisa Silander, et al.
(2010) The Lancet, 376 p.1393-1400
Journal articleGenetic susceptibility for obesity increases the risk of type 2 diabetes and is modified by macronutrient intakes
Gull Rukh, Emily Sonestedt, Valeriya Lyssenko, Amitabh Sharma, Olle Melander, et al.
(2010) Diabetologia, 53 p.50-50
Conference paper: abstractPlasma copeptin and the risk of diabetes mellitus.
Sofia Enhörning, Thomas J Wang, Peter Nilsson, Peter Almgren, Bo Hedblad, et al.
(2010) Circulation, 121 p.51-2102
Journal articleGenome-wide association study identifies eight loci associated with blood pressure
Christopher Newton-Cheh, Toby Johnson, Vesela Gateva, Martin D. Tobin, Murielle Bochud, et al.
(2009) Nature Genetics, 41 p.666-676
Journal articleAssociation between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states
Pablo Perez-Martinez, Dolores Corella, Jian Shen, Donna K. Arnett, Nikos Yiannakouris, et al.
(2009) American Journal of Clinical Nutrition, 89 p.391-399
Journal articleION Mobility Analysis Of Lipoprotein Subfractions Suggests Three Independent Mechanisms Of Cardiovascular Risk
K. Musunuru, Marju Orho-Melander, M. Caulfield, R. Reitz, Göran Berglund, et al.
(2009) Atherosclerosis Supplements, 10 p.17-17
Conference paper: abstractIon Mobility Analysis of Lipoprotein Subfractions Identifies 3 Independent Axes of Cardiovascular Risk
Kiran Musunuru, Marju Orho-Melander, Michael P. Caulfield, Shuguang Li, Wael A. Salameh, et al.
(2009) Circulation, 119 p.282-283
Conference paper: abstractGenetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts
Anna Kotronen, Hannele Yki-Jarvinen, Anna Aminoff, Robert Bergholm, Kirsi H. Pietilainen, et al.
(2009) European Journal of Endocrinology, 160 p.593-602
Journal articlePolymorphisms at newly identified lipid-associated loci are associated with blood lipids and cardiovascular disease in an Asian Malay population
E. Shyong Tai, Xue Ling Sim, Twee Hee Ong, Tien Yin Wong, Seang Mei Saw, et al.
(2009) Journal of Lipid Research, 50 p.514-520
Journal articleAssociation between fat intake, physical activity and mortality depending on genetiv variation in FTO
Emily Sonestedt, Bo Gullberg, Elisabet Wirfält, Bo Hedblad, Marju Orho-Melander
(2009) Diabetologia, 52 p.104-104
Conference paper: abstractThe P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver
Nicola L. Beer, Nicholas D. Tribble, Laura J. McCulloch, Charlotta Roos, Paul R. V. Johnson, et al.
(2009) Human Molecular Genetics, 18 p.4081-4088
Journal articleIon Mobility Analysis of Lipoprotein Subfractions Identifies Three Independent Axes of Cardiovascular Risk.
Kiran Musunuru, Marju Orho-Melander, Michael P Caulfield, Shuguang Li, Wael A Salameh, et al.
(2009) Arteriosclerosis, Thrombosis and Vascular Biology, 29 p.628-1975
Journal articleFat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity.
Emily Sonestedt, Charlotta Roos, Bo Gullberg, Ulrika Ericson, Elisabet Wirfält, et al.
(2009) The American journal of clinical nutrition, 90 p.1418-1425
Journal articleThe myocardial infarction associated CDKN2A/CDKN2B locus on chromosome 9p21 is associated with stroke independently of coronary events in patients with hypertension.
Björn Wahlstrand, Marju Orho-Melander, Lotta Delling, Sverre Kjeldsen, Krzysztof Narkiewicz, et al.
(2009) Journal of Hypertension, 27 p.769-773
Journal articleA common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans
A. Kotronen, L. E. Johansson, L. M. Johansson, C. Roos, J. Westerbacka, et al.
(2009) Diabetologia, 52 p.1056-1060
Journal articlePrediction of Non-Alcoholic Fatty Liver Disease and Liver Fat Using Metabolic and Genetic Factors
Anna Kotronen, Markku Peltonen, Antti Hakkarainen, Ksenia Sevastianova, Robert Bergholm, et al.
(2009) Gastroenterology, 137 p.865-872
Journal articleFunctional characterisation of the glucokinase regulatory protein gene variant P446L shows diminished regulation by fructose-6 phosphate resulting in increased glucokinase activity
N. L. Beer, N. D. Tribble, Charlotta Roos, Marju Orho-Melander, A. L. Gloyn
(2009) Diabetologia, 52 p.237-237
Conference paper: abstractCommon variants at 30 loci contribute to polygenic dyslipidemia
Sekar Kathiresan, Cristen J. Willer, Gina M. Peloso, Serkalem Demissie, Kiran Musunuru, et al.
(2009) Nature Genetics, 41 p.56-65
Journal articleC/EBP{alpha} in adipose tissue regulates genes in lipid and glucose metabolism and a genetic variation in C/EBP{alpha} is associated with serum levels of triglycerides.
Louise E Olofsson, Marju Orho-Melander, Lena William-Olsson, Kajsa Sjöholm, Lars Sjöström, et al.
(2008) Journal of Clinical Endocrinology and Metabolism, 93 p.4880-4886
Journal articleThe myocardial infarction associated CDKN2A/CDKN2B locus on chromosome 9p21 is associated with stroke independently of cardiovascular risk factors and coronary events in patients with hypertension
B Waldstrand, Marju Orho-Melander, S Kjeldsen, L Delling, K Narkiewicz, et al.
(2008) Journal of Hypertension, 26 p.141-142
Conference paper: abstractAssociation between an estrogen receptor alpha polymorphism (ERA : rs2234693) and the metabolic syndrome and cardiovascular and cerebrovascular morbidity and mortality
L Delling, B Wahlstrand, A Niklasson, K Stenlof, Marju Orho-Melander, et al.
(2008) Journal of Hypertension, 26 p.341-341
Conference paper: abstractA non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population
Caroline Brorsson, Regine Bergholdt, Marketa Sjögren, Stefanie Eising, Karina Meden Sorensen, et al.
(2008) Molecular Genetics and Metabolism, 94 p.386-388
Journal articleNew insights into impaired muscle glycogen synthesis.
Leif Groop, Marju Orho-Melander
(2008) PLoS Medicine, 5 p.18-19
Journal article (letter)The search for putative unifying genetic factors for components of the metabolic syndrome.
Marketa Sjögren, Valeriya Lyssenko, Anna Jonsson, Göran Berglund, Peter Nilsson, et al.
(2008) Diabetologia, 51 p.2242-2251
Journal articleUsing the mouse model to confirm genes identified by genomewide association studies for the complex trait HDL cholesterol
Magalie S Leduc, Ron Korstanje, Marju Orho-Melander, Sekar Kathiresan, Beverly Paigen
(2008) Arteriosclerosis, Thrombosis, and Vascular Biology, 28 p.36-36
Conference paper: abstractIs there a unifying genetic factor predisposing to the metabolic syndrome?
Marketa Sjögren, Marju Orho-Melander, Anna Jonsson, Margareta Svensson, Göran Berglund, et al.
(2008) Diabetologia, 51 p.32-33
Conference paper: abstractDefining the spectrum of alleles that contribute to blood lipid concentrations in humans
Sekar Kathiresan, Kiran Musunuru, Marju Orho-Melander
(2008) Current Opinion in Lipidology, 19 p.122-127
Journal article reviewCholesterol gene polymorphisms and cardiovascular events - Reply
Sekar Kathiresan, Christopher Newton-Cheh, Marju Orho-Melander
(2008) New England Journal of Medicine, 359 p.93-93
Journal article (letter)Common Missense Variant in the Glucokinase Regulatory Protein Gene Is Associated With Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations
Marju Orho-Melander, Olle Melander, Candace Guiducci, Pablo Perez-Martinez, Dolores Corella, et al.
(2008) Diabetes, 57 p.3112-3121
Journal articlePolymorphism associated with cholesterol and risk of cardiovascular events
Sekar Kathiresan, Olle Melander, Dragi Anevski, Candace Guiducci, Noël Burtt, et al.
(2008) New England Journal of Medicine, 358 p.1240-1249
Journal articleThe variable clinical phenotype of liver glycogen synthase deficiency
R. Spiegel, J. Mahamid, Marju Orho-Melander, D. Miron, Y. Horovitz
(2007) Journal of Pediatric Endocrinology & Metabolism, 20 p.1339-1342
Journal articleMechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes.
Valeriya Lyssenko, Roberto Lupi, Piero Marchetti, Silvia Del Guerra, Marju Orho-Melander, et al.
(2007) Journal of Clinical Investigation, 117 p.2155-2163
Journal articleGenome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
Richa Saxena, Benjamin F. Voight, Valeriya Lyssenko, Noel P. Burtt, Paul I. W. de Bakker, et al.
(2007) Science, 316 p.1331-1336
Journal articleVariation in GYS1 Interacts with Exercise and Gender to Predict Cardiovascular Mortality.
Jenny Fredriksson, Dragi Anevski, Peter Almgren, Marketa Sjögren, Valeriya Lyssenko, et al.
(2007) PLoS ONE, 2 p.285-285
Journal articleA genome-wide association study for blood lipid phenotypes in the Framingham Heart Study
Sekar Kathiresan, Alisa K. Manning, Serkalem Demissie, Ralph B. D'Agostino, Aarti Surti, et al.
(2007) BMC Medical Genetics, 8
Journal articleAssociation of the calpain-10 gene with type 2 diabetes in Europeans: Results of pooled and meta-analyses
Takafumi Tsuchiya, Peter E. H. Schwarz, Laura del Bosque-Plata, M. Geoffrey Hayes, Christian Dina, et al.
(2006) Molecular Genetics and Metabolism, 89 p.174-184
Journal articleCommon single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals
Richa Saxena, Lauren Gianniny, Noel P. Burtt, Valeriya Lyssenko, Candace Giuducci, et al.
(2006) Diabetes, 55 p.2890-2895
Journal articlePolymorphism in the MHC2TA gene is associated with features of the metabolic syndrome and cardiovascular mortality.
Eero Lindholm, Olle Melander, Peter Almgren, Göran Berglund, Carl-David Agardh, et al.
(2006) PLoS ONE, 1
Journal articleA polymorphism in the adiponectin gene influences adiponectin expression levels in visceral fat in obese subjects
Jenny Fredriksson, Emma A Nilsson, Marju Orho-Melander, Leif Groop, Martin Ridderstråle
(2006) International Journal of Obesity, 30 p.226-232
Journal articleGenetic prediction of future type 2 diabetes
Valeriya Lyssenko, Peter Almgren, Dragi Anevski, Marju Orho-Melander, Marketa Sjögren, et al.
(2005) PLoS Medicine, 2 p.1299-1308
Journal articleA male-specific quantitative trait locus on 1p21 controlling human stature
S Sammalisto, T Hiekkalinna, E Suviolahti, K Sood, A Metzidis, et al.
(2005) Journal of Medical Genetics, 42 p.932-939
Journal articleParallel manifestation of insulin resistance and beta cell decompensation is compatible with a common defect in Type 2 diabetes.
Devjit Tripathy, Karl-Fredrik Eriksson, Marju Orho-Melander, Jenny Fredriksson, G. Ahlqvist, et al.
(2004) Diabetologia, 47 p.782-793
Journal articleAssociation testing in 9,000 people fails to confirm the association of the insulin receptor substrate-1 G972R polymorphism with type 2 diabetes
JC Florez, Marketa Sjögren, N Burtt, Marju Orho-Melander, S Schayer, et al.
(2004) Diabetes, 53 p.3313-3318
Journal articleAssociation between a polymorphism in the carboxyl ester lipase gene and serum cholesterol profile
SH Bengtsson-Ellmark, J Nilsson, Marju Orho-Melander, K Dahlenborg, Leif Groop, et al.
(2004) European Journal of Human Genetics, 12 p.627-632
Journal articleCharacterization of the human skeletal muscle glycogen synthase gene (GYS1) promoter.
Jenny Fredriksson, Martin Ridderstråle, Leif Groop, Marju Orho-Melander
(2004) European Journal of Clinical Investigation, 34 p.113-121
Journal articleEffects of common polymorphisms in the alpha(1A)-, alpha(2B)-, beta(1)- and beta(2)-adrenoreceptors on haemodynamic responses to adrenaline
A Snapir, J Koskenvuo, J Toikka, Marju Orho-Melander, S Hinkka, et al.
(2003) Clinical Science, 104 p.509-520
Journal articleThe insertion/deletion variation in the alpha2B-adrenoceptor does not seem to modify the risk for acute myocardial infarction, but may modify the risk for hypertension in sib-pairs from families with type 2 diabetes
Amir Snapir, Mika Scheinin, Leif Groop, Marju Orho-Melander
(2003) Cardiovascular Diabetology, 2
Journal articleA genome wide scan for early onset primary hypertension in Scandinavians.
Fredrik von Wowern, Kristina Bengtsson Boström, Cecilia Lindgren, Marju Orho-Melander, Frej Fyhrquist, et al.
(2003) Human Molecular Genetics, 12 p.2077-2081
Journal articlePro-opiomelanocortin gene is associated with serum leptin levels in lean but not in obese individuals.
E Suviolahti, Martin Ridderstråle, Peter Almgren, Mia Klannemark, Olle Melander, et al.
(2003) International Journal of Obesity, 27 p.1204-1211
Journal articleGlycogen synthase deficiency (glycogen storage disease type 0) presenting with hyperglycemia and glucosuria: Report of three new mutations
BE Bachrach, DA Weinstein, Marju Orho-Melander, A Burgess, JI Wolfsdorf
(2002) Journal of Pediatrics, 140 p.781-783
Journal articlePolymorphism in the Calpain 10 gene influences glucose metabolism in human fat cells
J Hoffstedt, M Ryden, P Lofgren, Marju Orho-Melander, Leif Groop, et al.
(2002) Diabetologia, 45 p.276-282
Journal articleVariants in the calpain-10 gene predispose to insulin resistance and elevated free fatty acid levels.
Marju Orho-Melander, Mia Klannemark, Malin Svensson, Martin Ridderstråle, Cecilia Lindgren, et al.
(2002) Diabetes, 51 p.2658-2664
Journal articleCharacterization of a naturally occurring mutation (L107I) in the HNF1 alpha (MODY3) gene.
Camilla Cervin, Marju Orho-Melander, Martin Ridderstråle, M Lehto, Sebastian Barg, et al.
(2002) Diabetologia, 45 p.1703-1708
Journal articleCharacterization of the annexin I gene and evaluation of its role in type 2 diabetes
Cecilia M. Lindgren, Anita Ramelius, Marju Orho-Melander, Peter Almgren, Leif Groop
(2001) Diabetes, 50 p.2402-2405
Journal articleThe ACE gene I/D polymorphism is associated with higher mortality in men with hypertension and type 2 diabetes
K Bengtsson, Ulf Lindblad, Marju Orho-Melander, Olle Melander, Jonas Ranstam, et al.
(2001) Diabetologia, 44 p.35-35
Journal articleCommon variants in the beta2-(Gln27Glu) and beta3-(Trp64Arg)--adrenoceptor genes are associated with elevated serum NEFA concentrations and type II diabetes
M Carlsson, Marju Orho-Melander, J Hedenbro, Leif Groop
(2001) Diabetologia, 44 p.629-636
Journal articleBeta(2)-adrenergic receptor gene variation and hypertension in subjects with type 2 diabetes
Kristina Bengtsson, Marju Orho-Melander, Olle Melander, Ulf Lindblad, Jonas Ranstam, et al.
(2001) Hypertension, 37 p.1303-1308
Journal articlePolymorphism in the beta(1)-adrenergic receptor gene and hypertension
Kristina Bengtsson, Olle Melander, Marju Orho-Melander, Ulf Lindblad, Jonas Ranstam, et al.
(2001) Circulation, 104 p.187-190
Journal articleA gene conferring susceptibility to type 2 diabetes in conjunction with obesity is located on chromosome 18p11
Alex Parker, Joanne Meyer, Steve Lewitzky, Jean S. Rennich, Gayun Chan, et al.
(2001) Diabetes, 50 p.675-680
Journal articleThe dysmetabolic syndrome
Leif Groop, Marju Orho-Melander
(2001) Journal of Internal Medicine, 250 p.105-120
Journal articleInteraction between the Asn291Ser variant of the LPL gene and insulin resistance on dyslipidaemia in high risk individuals for Type 2 diabetes mellitus
Mia Klannemark, L Suurinkeroinen, Marju Orho-Melander, Leif Groop, M R Taskinen
(2000) Diabetic Medicine, 17 p.599-605
Journal articleGenetic variants of thiazide-sensitive NaCl-cotransporter in Gitelman's syndrome and primary hypertension
Olle Melander, Marju Orho-Melander, Kristina Bengtsson Boström, Ulf Lindblad, Lennart Råstam, et al.
(2000) Hypertension, 36 p.389-394
Journal articleAngiotensin converting enzyme (ACE) gene polymorphism in sarcoidosis in relation to associated autoimmune diseases
K I Papadopoulos, Olle Melander, Marju Orho-Melander, Leif Groop, M Carlsson, et al.
(2000) Journal of Internal Medicine, 247 p.71-77
Journal articleGenetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus
Y Horikawa, N Oda, N J Cox, X Li, Marju Orho-Melander, et al.
(2000) Nature Genetics, 26 p.163-175
Journal articleThe T 54 allele of the intestinal fatty acid-binding protein 2 is associated with a parental history of stroke
Martin Carlsson, Marju Orho-Melander, Jan Hedenbro, Peter Almgren, Leif Groop
(2000) Journal of Clinical Endocrinology and Metabolism, 85 p.2801-2804
Journal articleRole of the Gly460Trp polymorphism of the alpha-adducin gene in primary hypertension in Scandinavians
Olle Melander, K Bengtsson, Marju Orho-Melander, U Lindblad, C Forsblom, et al.
(2000) Journal of Human Hypertension, 14 p.43-46
Journal articleAssociation between a variant in the 11 beta-hydroxysteroid dehydrogenase type 2 gene and primary hypertension
Olle Melander, Marju Orho-Melander, K Bengtsson, U Lindblad, Lennart Råstam, et al.
(2000) Journal of Human Hypertension, 14 p.819-823
Journal articleExpression of naturally occurring variants in the muscle glycogen synthase gene
Marju Orho-Melander, H Shimomura, T Sanke, S K Rasmussen, K Nanjo, et al.
(1999) Diabetes, 48 p.918-920
Journal articlePolymorphism in the angiotensin converting enzyme but not in the angiotensinogen gene is associated with hypertension and type 2 diabetes: the Skaraborg Hypertension and diabetes project
Kristina Bengtsson Boström, Marju Orho-Melander, Ulf Lindblad, Olle Melander, Erik Bøg-Hansen, et al.
(1999) Journal of Hypertension, 17 p.1569-1575
Journal articleHuman glycogen synthase genes. Role in insulin resistance and hypoglycaemia
Marju Orho-Melander
(1999)
DissertationA paired-sibling analysis of the XbaI polymorphism in the muscle glycogen synthase gene
Marju Orho-Melander, Peter Almgren, T Kanninen, C Forsblom, Leif Groop
(1999) Diabetologia, 42 p.1138-1145
Journal article