
Marie Sjögren
Postdoctoral fellow

Current position/project
Postdoctoral fellow
"VDAC1 a common denominator of ß-cell and endothelial cell dysfunction in T2D with its complications". This project aims to identify and map the importance of mitochondrial voltage dependent-anion channel (VDAC) proteins in beta, kidney and endothelial cells under physiological and pathophysiological conditions.
Techniques
Techniques such as in vitro studies and cell culture, transfection, pharmacological approached, qPCR, Western Blot, ELISA and confocal immunofluorescence microscopy will be used during the project.
Background
I have a PhD degree in biomedical science with specialization in neuroendocrine pharmacology from the Brain Disease Biomarker Unit at BMC, Lund University in Sweden. We were targeting emergy metabolism with genetic and pharmacological approaches using in vivo and in vitro studies, trying to find new treatments in Huntingtons´s disease. Different techniques such as qPCR, Western Blot, ELISA, bright field microscopy; primary satellite cell culture, whole body perfusion, dissection, and blood sampling were used. I have experience in generating a novel mouse model, as well as performing behavior tests (paw clasping, open field, rotarod, marble burying, and novel object recognition) in mice. I have had the chance to publish my research as well as attend to different international conferences and seminars.
Publications
Displaying of publications. Sorted by year, then title.
Skeletal muscle regeneration is altered in the R6/2 mouse model of Huntington’s disease
Sanzana Hoque, Marie Sjögren, Valérie Allamand, Kinga Gawlik, Naomi Franke, et al.
(2022) , p.1-23
PreprintIncreased intestinal permeability and gut dysbiosis in the R6/2 mouse model of Huntington’s disease
Tiberiu Loredan Stan, Rana Soylu-Kucharz, Stephen Burleigh, Olena Prykhodko, Ling Cao, et al.
(2020) Scientific Reports, 10
Journal articleEnergy metabolism as a target for new treatment strategies in Huntington’s disease
Marie Sjögren
(2019) Lund University, Faculty of Medicine Doctoral Dissertation Series, 2019
DissertationLeptin deficiency reverses high metabolic state and weight loss without affecting central pathology in the R6/2 mouse model of Huntington's disease
Marie Sjögren, Rana Soylu-Kucharz, Unali Dandunna, Tiberiu Loredan Stan, Michele Cavalera, et al.
(2019) Neurobiology of Disease, 132
Journal articleDual Therapy with Liraglutide and Ghrelin Promotes Brain and Peripheral Energy Metabolism in the R6/2 Mouse Model of Huntington's Disease
Ana I. Duarte, Marie Sjögren, Maria S. Santos, Catarina R. Oliveira, Paula I. Moreira, et al.
(2018) Scientific Reports, 8
Journal articleA51 Genetically altering metabolism by leptin-deficiency affects peripheral disease features in the R6/2 mouse model of huntington´s disease
Marie Sjögren, Rana Soylu Kucharz, Tiberiu Loredan Stan, Unali Dandunna, Maria Björkqvist
(2018) Journal of Neurology, Neurosurgery and Psychiatry, 89 p.18-18
Conference paper: abstractEffects of dual administration of liraglutide and ghrelin on brain mitochondrial metabolism in the r6/2 mouse
Ana Duarte, Marie Sjögren, Débora Mena, Inês N Alves, Maria S. Santos, et al.
(2018) Journal of Neurology, Neurosurgery and Psychiatry, 89 p.92-92
Conference paper: abstractGhrelin rescues skeletal muscle catabolic profile in the R6/2 mouse model of Huntington's disease
Marie Sjögren, Ana I. Duarte, Andrew C McCourt, Liliya Shcherbina, Nils Wierup, et al.
(2017) Scientific Reports, 7
Journal articleNeurofilament light protein in CSF and blood is associated with neurodegeneration and disease severity in Huntington's disease
Rana Soylu-Kucharz, Åsa Sandelius, Marie Sjögren, Kaj Blennow, Edward J. Wild, et al.
(2017) Scientific Reports, 7
Journal articleL23 Effects of peripheral (co-)administration of liraglutide and ghrelin in the R6/2 mouse brain function
Ana Duarte, Marie Sjögren, Maria S. Santos, Catarina Resende De Oliveira, Paula I. Moreira, et al.
(2016) Journal of Neurology, Neurosurgery and Psychiatry, 87 p.98-98
Conference paper: abstractL24 The effect of ghrelin administration in the R6/2 mouse model of Huntington’s disease
Marie Sjögren, Ana Duarte, Andrew C Mccourt, Liliya Shcherbina, Ann-Helen Thorén Fischer, et al.
(2016) Journal of Neurology, Neurosurgery and Psychiatry, 87
Conference paper: abstract