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Maria Lindahl

Maria Lindahl

Research engineer

Maria Lindahl

Xylooligosaccharides Increase Bifidobacteria and Lachnospiraceae in Mice on a High-Fat Diet, with a Concomitant Increase in Short-Chain Fatty Acids, Especially Butyric Acid

Author

  • Karin Berger
  • Stephen Burleigh
  • Maria Lindahl
  • Abhishek Bhattacharya
  • Prachiti Patil
  • Henrik Stålbrand
  • Eva Nordberg Karlsson
  • Frida Hållenius
  • Margareta Nyman
  • Patrick Adlercreutz

Summary, in English

Effects of xylooligosaccharides (XOSs) as well as a mixture of XOS, inulin, oligofructose, and partially hydrolyzed guar gum (MIX) in mice fed a high-fat diet (HFD) were studied. Control groups were fed an HFD or a low-fat diet. Special attention was paid to the cecal composition of the gut microbiota and formation of short-chain fatty acids, but metabolic parameters were also documented. The XOS group had significantly higher cecum levels of acetic, propionic, and butyric acids than the HFD group, and the butyric acid content was higher in the XOS than in the MIX group. The cecum microbiota of the XOS group contained more Bifidobacteria, Lachnospiraceae, and S24-7 bacteria than the HFD group. A tendency of lower body weight gain was observed on comparing the XOS and HFD groups. In conclusion, the XOS was shown to be a promising prebiotic candidate. The fiber diversity in the MIX diet did not provide any advantages compared to the XOS diet.

Department/s

  • EXODIAB: Excellence of Diabetes Research in Sweden
  • Department Office of Experimental Medical Science
  • Department of Food Technology, Engineering and Nutrition
  • Protein Phosphorylation
  • Biochemistry and Structural Biology
  • Biotechnology

Publishing year

2021-03-16

Language

English

Pages

3617-3625

Publication/Series

Journal of Agricultural and Food Chemistry

Volume

69

Issue

12

Document type

Journal article

Publisher

The American Chemical Society (ACS)

Topic

  • Nutrition and Dietetics
  • Food Engineering

Keywords

  • Prebiotics
  • Xylooligosaccharides
  • Bifidobacteria
  • Lachnospiraceae
  • S24-7
  • Short-chain fatty acids
  • Butyrate
  • High-fat diet

Status

Published

Research group

  • Protein Phosphorylation

ISBN/ISSN/Other

  • ISSN: 0021-8561