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Maria Lindahl

Maria Lindahl

Research engineer

Maria Lindahl

Measurement of MR signal and T2* in lung to characterize a tight skin mouse model of emphysema using single-point imaging


  • Lars E Olsson
  • Maria Lindahl
  • Per-Ola Onnervik
  • Lars B Johansson
  • Malin Palmér
  • Martina Kvist Reimer
  • Leif Hultin
  • Paul D Hockings

Summary, in English

PURPOSE: To evaluate whether MRI signal and T2* measurements of lung tissue acquired at ultrashort detection times (tds) can detect emphysematous changes in lungs.

MATERIALS AND METHODS: MR signal intensity of in vivo mouse lungs was measured at 4.7 T at tds of 0.2 and 0.4 msec using single-point imaging (SPI). T2* was calculated from the measurements obtained at the two tds. Two groups of 8- and 30-week-old Tight Skin (TS) and aged-matched CB57BL/6 mice were examined. The TS mice spontaneously developed emphysema-like alveolar enlargement. In vivo micro-computed tomography (microCT) scanning and histology were used as reference methods.

RESULTS: MR signal and T2* were significantly lower in the lungs of TS mice than in controls. There were no significant differences between the different age groups. MR signal in lung parenchyma correlated linearly (P < 0.0001, r = 0.89) with microCT mass density, and T2* correlated linearly (P < 0.0001, r = -0.91) with the alveoli size (mean linear intercept [MLI]).

CONCLUSION: The MR signal intensity and T2* measured at short tds can be used as imaging biomarkers to characterize parenchyma density and alveolar size, respectively.

Publishing year







Journal of Magnetic Resonance Imaging





Document type

Journal article


John Wiley & Sons Inc.


  • Age Factors
  • Animals
  • Disease Models, Animal
  • Disease Progression
  • Emphysema
  • Image Processing, Computer-Assisted
  • Imaging, Three-Dimensional
  • Lung
  • Magnetic Resonance Imaging
  • Mice
  • Signal Processing, Computer-Assisted
  • Tomography, X-Ray Computed




  • ISSN: 1053-1807