Lund University is celebrating 350 years.


Javascript is not activated in your browser. This website needs javascript activated to work properly.

Dual actions of apolipoprotein A-I on glucose-stimulated insulin secretion and insulin-independent peripheral tissue glucose uptake lead to increased heart and skeletal muscle glucose disposal

  • Joan Domingo-Espín
  • Maria Lindahl
  • Oktawia Nilsson
  • Samuel W Cushman
  • Karin G. Stenkula
  • Jens O. Lagerstedt
Publishing year: 2016-07-01
Language: English
Pages: 1838-1848
Publication/Series: Diabetes
Volume: 65
Issue: 7
Document type: Journal article
Publisher: American Diabetes Association Inc.

Abstract english

Apolipoprotein A-I (apoA-I) of HDL is central to the transport of cholesterol in circulation. ApoA-I also provides glucose control with described in vitro effects of apoA-I on β-cell insulin secretion and muscle glucose uptake. In addition, apoA-I injections in insulin-resistant diet-induced obese (DIO) mice lead to increased glucose-stimulated insulin secretion (GSIS) and peripheral tissue glucose uptake. However, the relative contribution of apoA-I as an enhancer of GSIS in vivo and as a direct stimulator of insulin-independent glucose uptake is not known. Here, DIO mice with instant and transient blockade of insulin secretion were used in glucose tolerance tests and in positron emission tomography analyses. Data demonstrate that apoA-I to an equal extent enhances GSIS and acts as peripheral tissue activator of insulin-independent glucose uptake and verify skeletal muscle as an apoA-I target tissue. Intriguingly, our analyses also identify the heart as an important target tissue for the apoA-I-stimulated glucose uptake, with potential implications in diabetic cardiomyopathy. Explorations of apoA-I as a novel antidiabetic drug should extend to treatments of diabetic cardiomyopathy and other cardiovascular diseases in patients with diabetes.


  • Endocrinology and Diabetes


  • ISSN: 0012-1797
Maria Lindahl
E-mail: maria [dot] lindahl [at] med [dot] lu [dot] se

Research engineer

Glucose Transport and Protein Trafficking

+46 46 222 08 78

BMC C1118b


Lund University Diabetes Centre, CRC, SUS Malmö, Entrance 72, House 91:12. SE-205 02 Malmö. Telephone: +46 40 39 10 00