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Maria Gomez

Maria Gomez

Professor

Maria Gomez

Regulation of Ca2+ channel and phosphatase activities by polyamines in intestinal and vascular smooth muscle - implications for cellular growth and contractility.

Author

  • Bengt-Olof Nilsson
  • Maria Gomez
  • Karl Swärd
  • Per Hellstrand

Summary, in English

Polyamines added extracellularly to intestinal and vascular smooth muscle cells cause relaxation through inhibition of Ca2+ channel activity. Intracellularly applied polyamines also affect Ca2+ channel properties. Polyamines do not readily pass over the plasma membrane because of their positive charges but in permeabilized smooth muscle preparations they have free access to the cytoplasm. In this system they increase sensitivity of the contractile machinery to Ca2+ through inhibition of myosin phosphatase activity. The magnitude of Ca2+ channel and phosphatase inhibition depends on the number of positive charges on the polyamine molecule. Polyamines have an obligatory, but yet undefined, role in regulation of cell growth and proliferation. Several groups of protein kinases, such as tyrosine and mitogen activated protein (MAP)-kinases transmit the growth signal from the plasma membrane to the cell nucleus where mitosis and protein synthesis are initiated. The data reviewed here show that polyamines may affect such signal transmission via inhibition of phosphatase activity.

Department/s

  • Vascular Physiology
  • Cardiovascular Research - Immunity and Atherosclerosis
  • Cellular Biomechanics

Publishing year

2002

Language

English

Pages

33-41

Publication/Series

Acta Physiologica Scandinavica

Volume

176

Issue

1

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Cardiac and Cardiovascular Systems
  • Cell and Molecular Biology
  • Physiology

Status

Published

Research group

  • Vascular Physiology
  • Cardiovascular Research - Immunity and Atherosclerosis
  • Cellular Biomechanics

ISBN/ISSN/Other

  • ISSN: 0001-6772