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Maria Gomez

Maria Gomez

Professor

Maria Gomez

Syndecan-4 is a key determinant of collagen cross-linking and passive myocardial stiffness in the pressure-overloaded heart.

Author

  • Kate Herum Möller
  • Ida G Lunde
  • Biljana Skrbic
  • William E Louch
  • Almira Hasic
  • Sigurd Boye
  • Andreas Unger
  • Sverre-Henning Brorson
  • Ivar Sjaastad
  • Theis Tønnessen
  • Wolfgang A Linke
  • Maria Gomez
  • Geir Christensen

Summary, in English

Diastolic dysfunction is central to the development of heart failure. To date, there is no effective treatment and only limited understanding of its molecular basis. Recently, we showed that the transmembrane proteoglycan syndecan-4 increases in the left ventricle after pressure overload in mice and man, and that syndecan-4 via calcineurin/nuclear factor of activated T-cells (NFAT) promotes myofibroblast differentiation and collagen production upon mechanical stress. The aim of this study was to investigate whether syndecan-4 affects collagen cross-linking and myocardial stiffening in the pressure-overloaded heart.

Department/s

  • Diabetic Complications
  • EXODIAB: Excellence in Diabetes Research in Sweden

Publishing year

2015

Language

English

Pages

217-226

Publication/Series

Cardiovascular Research

Volume

106

Issue

2

Document type

Journal article

Publisher

Oxford University Press

Topic

  • Cardiac and Cardiovascular Systems

Status

Published

Research group

  • Diabetic Complications

ISBN/ISSN/Other

  • ISSN: 1755-3245