Your browser has javascript turned off or blocked. This will lead to some parts of our website to not work properly or at all. Turn on javascript for best performance.

The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Maria Gomez

Maria Gomez

Professor

Maria Gomez

NFAT regulation in smooth muscle

Author

  • DC Hill-Eubanks
  • Maria Gomez
  • AS Stevenson
  • MT Nelson

Summary, in English

First identified in activated T cells, the calcium (Ca2+)-dependent transcription factor, nuclear factor of activated T cells (NFAT), has since been shown to play a role in nonimmune cells, including cells of the cardiovascular system. In arterial smooth muscle, the diverse array of calcium-signaling modalities, the functional interplay between smooth muscle and endothelial cells, and the influence of intravascular pressure on calcium and other signaling pathways creates a calcium-regulatory environment that is arguably unique. This review focuses on mechanisms that control the initial Ca2+/calcineurin-dependent events in NFAT activation, with a particular emphasis on NFAT regulation in native vascular smooth muscle. Also addressed is the role of additional mechanisms that act to modulate calcineurin-dependent NFAT nuclear import/export, mechanisms that may have particular relevance in this tissue. (C) 2003, Elsevier Science Inc.

Department/s

  • Vascular Physiology

Publishing year

2003

Language

English

Pages

56-62

Publication/Series

Trends in Cardiovascular Medicine

Volume

13

Issue

2

Document type

Journal article review

Publisher

Elsevier

Topic

  • Physiology

Status

Published

Research group

  • Vascular Physiology

ISBN/ISSN/Other

  • ISSN: 1873-2615