
Malin Fex
Researcher

I am born and raised in Sweden, and received both my master and PhD at Lund University. The overarching goal of my research is to understand why the pancreatic beta cells fail to produce adequate amounts of insulin to regulate whole body metabolism in type 2 diabetes (T2D). I focus mainly on monoamine signaling within the islet of Langerhans and we have produced a substantial amount of work focusing on the role of serotonin and melatonin in regulation of islet function. Another focus of my research is mechanisms of autophagy, a tightly regulated process involved in cell maintenance and cell survival. Here we focus on the role of autophagy in pancreatic beta cells during metabolic stress and type 2 diabetes.
In my spare, time I like to work in my garden, exercise and spend time with my family.
Publications
Displaying of publications. Sorted by year, then title.
A critical role of the mechanosensor PIEZO1 in glucose-induced insulin secretion in pancreatic β-cells
Yingying Ye, Mohammad Barghouth, Haiqiang Dou, Cheng Luan, Yongzhi Wang, et al.
(2022) Nature Communications, 13
Journal articleThe impact of macronutrient composition on metabolic regulation : An Islet-Centric view
Klinsmann Carolo dos Santos, Camilla Olofsson, João Paulo M.C.M. Cunha, Fiona Roberts, Sergiu Bogdan Catrina, et al.
(2022) Acta Physiologica, 236
Journal articleRibosomal biogenesis regulator DIMT1 controls β-cell protein synthesis, mitochondrial function, and insulin secretion
Gaurav Verma, Alexander Bowen, Sevda Gheibi, Alexander Hamilton, Sowndarya Muthukumar, et al.
(2022) The Journal of biological chemistry, 298
Journal articleA cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development
Pia A Johansson, Per Ludvik Brattås, Christopher H Douse, PingHsun Hsieh, Anita Adami, et al.
(2022) Cell Stem Cell, 29 p.8-69
Journal articleThe human batokine EPDR1 regulates β-cell metabolism and function
Luis Rodrigo Cataldo, Qian Gao, Lidia Argemi-Muntadas, Ondrej Hodek, Elaine Cowan, et al.
(2022) Molecular Metabolism, 66
Journal articleHigh-fat diet-induced diabetes leads to vascular alterations, pericyte reduction, and perivascular depletion of microglia in a 6-OHDA toxin model of Parkinson disease
Osama F. Elabi, João Paulo M.C.M. Cunha, Abderahim Gaceb, Malin Fex, Gesine Paul
(2021) Journal of Neuroinflammation, 18
Journal articleMitochondrial clearance of calcium facilitated by MICU2 controls insulin secretion
N. Vishnu, A. Hamilton, A. Bagge, A. Wernersson, E. Cowan, et al.
(2021) Molecular Metabolism, 51
Journal articleThe Vbeta13 T Cell Receptor Monoclonal Antibody Reduces Hyaluronan and CD68+, CD3+, and CD8+ Cell Infiltrations to Delay Diabetes in Congenic BB DRLyp/Lyp Rats
Marika Bogdani, Linda Faxius, Malin Fex, Anita Ramelius, Anya Wernersson, et al.
(2021) Frontiers in Endocrinology, 12
Journal articleThe MafA-target gene PPP1R1A regulates GLP1R-mediated amplification of glucose-stimulated insulin secretion in β-cells
Luis Rodrigo Cataldo, Neelanjan Vishnu, Tania Singh, Ludivine Bertonnier-Brouty, Sara Bsharat, et al.
(2021) Metabolism: Clinical and Experimental
Journal articleHuman enteroviral infection impairs autophagy in clonal INS(832/13) cells and human pancreatic islet cells
Anya Wernersson, Luis Sarmiento, Elaine Cowan, Malin Fex, Corrado M. Cilio
(2020) Diabetologia, 63 p.2372-2384
Journal articleInsulin/Glucose-Responsive Cells Derived from Induced Pluripotent Stem Cells: Disease Modeling and Treatment of Diabetes
Sevda Gheibi, Tania Singh, Joao Paulo M. C. M. da Cunha, Malin Fex, Hindrik Mulder
(2020) Cells, 9
Journal article reviewLack of melatonin type 1 receptor results in dysregulated alpha cell function and metabolism
CL Lyons, A Hamilton, D Grajales, L Shcherbina, A Lindqvist, et al.
(2020) Diabetologia, 63 p.231-231
Conference paper: abstractHighly blood perfused, highly metabolically active pancreatic islets may be more susceptible for immune attack
Sara Ullsten, Daniel Espes, My Quach, Malin Fex, Monica Sandberg, et al.
(2020) Physiological Reports, 8
Journal articleLoss of MafA and MafB expression promotes islet inflammation.
Tania Singh, Jesper K. Colberg, Luis Sarmiento, Patricia Chaves, Lisbeth Hansen, et al.
(2019) Scientific Reports, 9
Journal articleSerotonergic Regulation of Insulin Secretion
Luis Rodrigo Cataldo Bascuñan, Claire Lyons, Hedvig Bennet, Isabella Artner, Malin Fex
(2019) Acta Physiologica, 225
Journal article reviewPlatelet Serotonin Levels Are Associated with Plasma Soluble Leptin Receptor Concentrations in Normoglycemic Women
Rodrigo Cataldo Buscunan, José Suazo, Pablo Olmos, Carolina Bravo, José E. Galgani, et al.
(2019) Journal of Diabetes Research, 2019
Journal article5-hydroxytryptamine in the endocrine pancreas
Malin Fex
(2019) Serotonin : The Mediator that Spans Evolution , p.81-90
Book chapterSerotonin and adipocyte function
Malin Fex, Karin G. Stenkula
(2019) Serotonin : The Mediator that Spans Evolution , p.197-202
Book chapterLack of melatonin type 1A receptor results in dysregulated whole-body metabolism characterised by hyperglucagonaemia, glucose intolerance and enhanced insulin secretion
C.L. Lyons, D. Grajales, A. Hamilton, H. Mulder, M. Fex
(2019) Diabetologia, 62 p.267-267
Conference paper: abstractBrain alpha-amylase : a novel energy regulator important in Alzheimer disease?
Elin Byman, Nina Schultz, Malin Fex, Malin Wennström
(2018) Brain Pathology, 28 p.920-932
Journal articleGlutamine-elicited secretion of glucagon-like peptide 1 is governed by an activated glutamate dehydrogenase
Lotta E. Andersson, Liliya Shcherbina, Mahmoud Al-Majdoub, Neelanjan Vishnu, Claudia Balderas Arroyo, et al.
(2018) Diabetes, 67 p.372-384
Journal articleEarly deficits in insulin secretion, beta cell mass and islet blood perfusion precede onset of autoimmune type 1 diabetes in BioBreeding rats
Anya Medina, Saba Parween, Sara Ullsten, Neelanjan Vishnu, Yuk Ting Siu, et al.
(2018) Diabetologia, 61 p.896-905
Journal articleThe pathogenetic role of β-cell mitochondria in type 2 diabetes
Malin Fex, Lisa M. Nicholas, Neelanjan Vishnu, Anya Medina, Vladimir V. Sharoyko, et al.
(2018) Journal of Endocrinology, 236 p.145-149
Journal article reviewLoss of melatonin receptor 1 in mouse pancreatic islets results in dysregulated glucagon secretion in vitro
C.L. Lyons, E Cowan, D.G. Abellan, C.L.F. Nagorny, H. Mulder, et al.
(2018) Diabetologia, 61 p.244-244
Conference paper: abstractAntibody Affinity Against 2009 A/H1N1 Influenza and Pandemrix Vaccine Nucleoproteins Differs Between Childhood Narcolepsy Patients and Controls
Alexander Lind, Eva Freyhult, Anita Ramelius, Tomas Olsson, Lisen Arnheim-Dahlström, et al.
(2017) Viral Immunology, 30 p.590-600
Journal articleMitochondrial transcription factor B2 is essential for mitochondrial and cellular function in pancreatic β-cells
Lisa M. Nicholas, Bérengère Valtat, Anya Medina Benavente, Lotta Andersson, Mia Abels, et al.
(2017) Molecular Metabolism, 6 p.651-663
Journal articleSox5 regulates beta-cell phenotype and is reduced in type 2 diabetes
Annika Axelsson, T Mahdi, H A Nenonen, Tania Singh, S Hänzelmann, et al.
(2017) Nature Communications, 8 p.15652-15652
Journal articleCharacterization of resident lymphocytes in human pancreatic islets
M. Radenkovic, K Uvebrant, O. Skog, Luis Sarmiento-Pérez, J. Avartsson, et al.
(2017) Clinical and Experimental Immunology, 187 p.418-427
Journal articleAn Increased Diagnostic Sensitivity of Truncated GAD65 Autoantibodies in Type 1 Diabetes May Be Related to HLA-DQ8
Axel Wester, Hanna Skärstrand, Alexander Lind, Anita Ramelius, Annelie Carlsson, et al.
(2017) Diabetes, 66 p.735-740
Journal articleAmylin alters human brain pericyte viability and NG2 expression
Nina Schultz, Elin Byman, Malin Fex, Malin Wennström
(2017) Journal of Cerebral Blood Flow and Metabolism, 37 p.1470-1482
Journal articleGlycogen metabolism in the glucose-sensing and supply-driven β-cell
Lotta E. Andersson, Lisa M. Nicholas, Karin Filipsson, Jiangming Sun, Anya Medina Benavente, et al.
(2016) FEBS Letters, 590 p.4242-4251
Journal article (letter)Influence of a HTR2B stop codon on glucagon homeostasis and glucose excursion in non-diabetic men
R. Tikkanen, T. Saukkonen, M. Fex, H. Bennet, M. R. Rautiainen, et al.
(2016) Experimental and Clinical Endocrinology & Diabetes, 124 p.529-534
Journal articleThe effects of a HTR2B stop codon and testosterone on energy metabolism and beta cell function among antisocial Finnish males
Roope Tikkanen, Tero Saukkonen, Malin Fex, Hedvig Bennet, Marja Riitta Rautiainen, et al.
(2016) Journal of Psychiatric Research, 81 p.79-86
Journal articleCART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion
Mia Abels, Matteo Riva, Hedvig Bennet, Emma Ahlqvist, Oleg Dyachok, et al.
(2016) Diabetologia, 59 p.1928-1937
Journal articleIncreased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes
Tiinamaija Tuomi, Cecilia L F Nagorny, Pratibha Singh, Hedvig Bennet, Qian Yu, et al.
(2016) Cell Metabolism, 23 p.1067-1077
Journal articleSerotonin (5-HT) and 5-HT2A receptor agonists suppress lipolysis in primary rat adipose cells
Björn Hansson, Anya Medina Benavente, Claes Fryklund, Malin Fex, Karin G. Stenkula
(2016) Biochemical and Biophysical Research Communications, 474 p.357-363
Journal articleSerotonin (5-HT) receptor 2b activation augments glucose-stimulated insulin secretion in human and mouse islets of Langerhans.
Hedvig Bennet, Ines Mollet, Alexander Balhuizen, Anya Medina Benavente, Cecilia Nagorny, et al.
(2016) Diabetologia, 59 p.744-754
Journal articleMafA-Controlled Nicotinic Receptor Expression Is Essential for Insulin Secretion and Is Impaired in Patients with Type 2 Diabetes.
Elvira Ganic, Tania Singh, Cheng Luan, Joao Fadista, Jenny Johansson, et al.
(2016) Cell Reports, 14 p.1991-2002
Journal articleDifferential effects of three echovirus strains on cell lysis and insulin secretion in beta cell derived lines.
Luis Sarmiento-Pérez, Anya Medina Benavente, Eitan Netanyah, Mahesh Anagandula, Eduardo Cabrera-Rode, et al.
(2016) Journal of Medical Virology, 88 p.971-978
Journal articleElevated Serum GAD65 and GAD65-GADA Immune Complexes in Stiff Person Syndrome.
Gucci Jijuan Gu Urban, Mikaela Friedman, Ping Ren, Carina Törn, Malin Fex, et al.
(2015) Scientific Reports, 5
Journal articleDoubly reactive INS-IGF2 autoantibodies in children with newly diagnosed autoimmune (type 1) diabetes.
Norio Kanatsuna, Ahmed Delli, Cecilia K Andersson, Anna-Lena Nilsson, Fariba Vaziri Sani, et al.
(2015) Scandinavian Journal of Immunology, 82 p.361-369
Journal articlePhotocoagulation of human retinal pigment epithelium in vitro: unravelling the effects on ARPE-19 by transcriptomics and proteomics.
Poya T-Khani, Carolina de la Torre, Francesc Canals, Hedvig Bennet, Rafael Simo, et al.
(2015) Acta Ophthalmologica, 93 p.348-354
Journal articleSerum cytokine pattern in young children with screening detected celiac disease.
Sara Björck, Sabina Lindehammer, Malin Fex, Daniel Agardh
(2015) Clinical and Experimental Immunology, 179 p.230-235
Journal articleAltered serotonin (5-HT) 1D and 2A receptor expression may contribute to defective insulin and glucagon secretion in human type 2 diabetes.
Hedvig Bennet, Alexander Balhuizen, Anya Medina Benavente, Marloes Dekker Nitert, Emilia Ottosson Laakso, et al.
(2015) Peptides, 71 p.113-120
Journal articleIslet-specific monoamine oxidase A and B expression depends on MafA transcriptional activity and is compromised in type 2 diabetes.
Elvira Ganic, Jenny Johansson, Hedvig Bennet, Malin Fex, Isabella Artner
(2015) Biochemical and Biophysical Research Communications, 468 p.629-635
Journal articleTCF7L2 is a master regulator of insulin production and processing.
Yuedan Zhou, Soo-Young Park, Jing Su, Kathleen Bailey, Emilia Ottosson Laakso, et al.
(2014) Human Molecular Genetics, 23 p.6419-6431
Journal articleThe Complement Inhibitor CD59 Regulates Insulin Secretion by Modulating Exocytotic Events.
Ulrika Krus, Ben King, Vini Nagaraj, Nikhil R Gandasi, Jonatan Sjölander, et al.
(2014) Cell Metabolism, 19 p.883-890
Journal articleMicrophthalmia transcription factor regulates pancreatic β-cell function
Magdalena Mazur, Marcus Winkler, Elvira Ganic, Jesper K. Colberg, Jenny Johansson, et al.
(2013) Diabetes, 62 p.2834-2842
Journal articleAutoimmunity against INS-IGF2 expressed in human pancreatic islets.
Norio Kanatsuna, Jalal Taneera, Fariba Vaziri Sani, Nils Wierup, Helena Larsson, et al.
(2013) Journal of Biological Chemistry, 288 p.29013-29023
Journal articleHTR1A a Novel Type 1 Diabetes Susceptibility Gene on Chromosome 5p13-q13
Samina Asad, Pernilla Nikamo, Alexandra Gyllenberg, Hedvig Bennet, Ola Hansson, et al.
(2012) PLoS ONE, 7
Journal articleEarly-Pregnancy Cytokines in Mothers to Children Developing Multiple, Persistent Islet Autoantibodies, Type 1 Diabetes, or Both Before 7 Years of Age.
Sabina Lindehammer, Malin Fex, Marlena Maziarz, Ida Hanson, Karel Marsal, et al.
(2011) American Journal of Reproductive Immunology, 66 p.495-503
Journal articleEarly human pregnancy serum cytokine levels predict autoimmunity in offspring.
Sabina Lindehammer, Sara Björck, Kristian Lynch, Charlotte Brundin, Karel Marsal, et al.
(2011) Autoimmunity, 44 p.445-452
Journal articleFirst trimester cytokine levels in mothers to children diagnosed with islet autoimmunity or type 1 diabetes before eight years of age
Malin Fex, Sara Björck, Kristian Lynch, Charlotte Brundin, Karel Marsal, et al.
(2010) Diabetologia, 53 p.344-344
Conference paper: abstractFirst trimester cytokine levels in mothers to children diagnosed with islet autoimmunity or type 1 diabetes before eight years of age
Sabina Lindehammer, Malin Fex, Karel Marsal, Åke Lernmark
(2010) Diabetologia, 53 p.343-343
Conference paper: abstractPancreatic islets of melatonin receptor knock-out mice
Cecilia Nagorny, Ulrikke Voss, Hedvig Bennet, Jelena Stamenkovic, Ramasri Sathanoori, et al.
(2010) Diabetologia, 53 p.294-294
Conference paper: abstractStimulation of 5-HT1a receptor decreased insulin secretion in islets of Langerhans from mice and humans
Hedvig Bennet, Cecilia Nagorny, Nils Wierup, Marloes Dekker Nitert, Åke Lernmark, et al.
(2010) Diabetologia, 53 p.547-547
Conference paper: abstractApelin is expressed in human and rodent islets and regulates insulin secretion
Camilla Ringstrom, Marloes Dekker Nitert, Hedvig Bennet, Malin Fex, Philippe Valet, et al.
(2010) Regulatory Peptides, 164 p.27-27
Conference paper: abstractApelin is a novel islet peptide.
Camilla Ringström, Marloes Dekker Nitert, Hedvig Bennet, Malin Fex, Philippe Valet, et al.
(2010) Regulatory Peptides, 162 p.44-51
Journal articleC-peptide in dried blood spots.
Jesper Johansson, Charlotte Becker, Nils Persson, Malin Fex, Carina Törn
(2010) Scandinavian Journal of Clinical and Laboratory Investigation, 70 p.404-409
Journal articleCommon variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion.
Valeriya Lyssenko, Cecilia Nagorny, Michael R Erdos, Nils Wierup, Anna Jonsson, et al.
(2009) Nature Genetics, 41 p.82-88
Journal articleA beta cell-specific knockout of hormone-sensitive lipase in mice results in hyperglycaemia and disruption of exocytosis.
Malin Fex, G Haemmerle, Nils Wierup, Marloes Dekker Nitert, M Rehn, et al.
(2009) Diabetologia, 52 p.271-280
Journal articleProteomic studies in animal models of diabetes
Svante Resjö, Karin Berger, Malin Fex, Ola Hansson
(2008) Proteomics Clinical Applications, 2 p.654-669
Journal article reviewLipases in the pancreatic beta-cell: implications for insulin secretion.
Malin Fex, Hindrik Mulder
(2008) Biochemical Society Transactions, 36 p.885-890
Journal articleRat insulin promoter 2-Cre recombinase mice bred onto a pure C57BL/6J background exhibit unaltered glucose tolerance
Malin Fex, Nils Wierup, Marloes Dekker Nitert, Michael Ristow, Hindrik Mulder
(2007) Journal of Endocrinology, 194 p.551-555
Journal articleEnhanced mitochondrial metabolism may account for the adaptation to insulin resistance in islets from C57BL/6J mice fed a high-fat diet.
Malin Fex, Marloes Dekker Nitert, Nils Wierup, Frank Sundler, Charlotte Ling, et al.
(2007) Diabetologia, 50 p.74-83
Journal articleLipid metabolism in the pancreatic beta-cell. Implications for insulin secretion.
Malin Fex
(2006)
Dissertation{beta}-Cell Lipases and Insulin Secretion.
Malin Fex, Stephanie Lucas, Maria Sörhede Winzell, Bo Ahrén, Cecilia Holm, et al.
(2006) Diabetes, 55 p.24-31
Journal article140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry.
Tord Berggård, Giorgio Arrigoni, Olof Olsson, Malin Fex, Sara Linse, et al.
(2006) Journal of Proteome Research, 5 p.669-687
Journal articleThe R6/2 transgenic mouse model of Huntington's disease develops diabetes due to deficient {beta}-cell mass and exocytosis.
Maria Björkqvist, Malin Fex, Erik Renström, Nils Wierup, Åsa Petersén, et al.
(2005) Human Molecular Genetics, 14 p.565-574
Journal articleHormone-sensitive Lipase deficiency in mouse islets abolishes neutral cholesterol ester hydrolase activity but leaves lipolysis, acylglycerides, fat oxidation, and insulin secretion intact.
Malin Fex, Charlotta S. Olofsson, Ulrika Krus, Karl Bacos, Håkan Lindvall, et al.
(2004) Endocrinology, 145 p.3746-3753
Journal articleFrataxin deficiency in pancreatic islets causes diabetes due to loss of β cell mass
Michael Ristow, Hindrik Mulder, Doreen Pomplun, Tim J. Schulz, Katrin Müller-Schmehl, et al.
(2003) Journal of Clinical Investigation, 112 p.527-534
Journal articleFrataxin deficiency in pancreatic islets causes diabetes due to loss of beta cell mass
M Ristow, Hindrik Mulder, D Pomplun, T Schulz, K Muller-Schmehl, et al.
(2003) Journal of Clinical Investigation, 112 p.527-534
Journal articleHormone-sensitive lipase null mice exhibit signs of impaired insulin sensitivity whereas insulin secretion is intact.
Hindrik Mulder, Maria Sorhede-Winzell, Juan Antonio Contreras, Malin Fex, Kristoffer Strom, et al.
(2003) Journal of Biological Chemistry, 278 p.36380-36388
Journal article