
Luis Sarmiento-Pérez
Assistant researcher

Mecanismo de participación de los Enterovirus en la neuropatía epidémica. Hipótesis fisiopatológicas
Mechanism of Enterovirus participation in epidemic neuropathy. Physiopathological hypothesis
Author
Summary, in English
During the epidemic neuropathy occurred in Cuba from 1992 to 1993, viral isolations antigenically connected with Coxsackie viruses were obtained from the cerebrospinal fluid of patients. Virological, epidemiological, toxicologic, nutritional, immunological and histopathological investigations were made. Though the disease was related to toxic and nutritional factors, it has been impossible to identify the cause of the epidemic. Taking into consideration the results of the different investigations, we have formulated a comprehensive and multifactorial hypothesis to explain the physiopathological mechanism of the participation of the isolated viruses as mediators in a process of autoimmunity of the pathogeny of the disease.
Publishing year
1997
Language
Spanish
Pages
95-186
Publication/Series
Revista cubana de medicina tropical
Volume
49
Issue
3
Links
Document type
Journal article
Publisher
Editorial Ciencias Medicas
Topic
- Immunology in the medical area
Keywords
- Animals
- Autoimmune Diseases/cerebrospinal fluid
- Cerebrospinal Fluid/virology
- Coxsackievirus Infections/complications
- Cuba/epidemiology
- Cytopathogenic Effect, Viral
- Disease Outbreaks
- Enterovirus/immunology
- Humans
- Interleukin-2/biosynthesis
- Mice
- Models, Biological
- Molecular Mimicry
- Nerve Tissue Proteins/immunology
- Nutrition Disorders/complications
- Optic Nerve Diseases/cerebrospinal fluid
- Peripheral Nervous System Diseases/cerebrospinal fluid
- Smoking/adverse effects
- T-Lymphocyte Subsets/immunology
- Viral Proteins/immunology
- Virus Latency
Status
Published
ISBN/ISSN/Other
- ISSN: 0375-0760