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Luis Sarmiento-Pérez

Assistant researcher

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Mecanismo de participación de los Enterovirus en la neuropatía epidémica. Hipótesis fisiopatológicas

Mechanism of Enterovirus participation in epidemic neuropathy. Physiopathological hypothesis

Author

  • P Más Lago
  • M G Guzmán
  • L Sarmiento Pérez
  • A B Pérez
  • M Alvarez
  • V Capó
  • G Kourí

Summary, in English

During the epidemic neuropathy occurred in Cuba from 1992 to 1993, viral isolations antigenically connected with Coxsackie viruses were obtained from the cerebrospinal fluid of patients. Virological, epidemiological, toxicologic, nutritional, immunological and histopathological investigations were made. Though the disease was related to toxic and nutritional factors, it has been impossible to identify the cause of the epidemic. Taking into consideration the results of the different investigations, we have formulated a comprehensive and multifactorial hypothesis to explain the physiopathological mechanism of the participation of the isolated viruses as mediators in a process of autoimmunity of the pathogeny of the disease.

Publishing year

1997

Language

Spanish

Pages

95-186

Publication/Series

Revista cubana de medicina tropical

Volume

49

Issue

3

Document type

Journal article

Publisher

Editorial Ciencias Medicas

Topic

  • Immunology in the medical area

Keywords

  • Animals
  • Autoimmune Diseases/cerebrospinal fluid
  • Cerebrospinal Fluid/virology
  • Coxsackievirus Infections/complications
  • Cuba/epidemiology
  • Cytopathogenic Effect, Viral
  • Disease Outbreaks
  • Enterovirus/immunology
  • Humans
  • Interleukin-2/biosynthesis
  • Mice
  • Models, Biological
  • Molecular Mimicry
  • Nerve Tissue Proteins/immunology
  • Nutrition Disorders/complications
  • Optic Nerve Diseases/cerebrospinal fluid
  • Peripheral Nervous System Diseases/cerebrospinal fluid
  • Smoking/adverse effects
  • T-Lymphocyte Subsets/immunology
  • Viral Proteins/immunology
  • Virus Latency

Status

Published

ISBN/ISSN/Other

  • ISSN: 0375-0760