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Luis Sarmiento-Pérez

Assistant researcher

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Persistence of vaccine-derived poliovirus following a mass vaccination campaign in Cuba : implications for stopping polio vaccination after global eradication

Author

  • P Más Lago
  • V M Cáceres
  • M A Galindo
  • H E Gary
  • M Valcarcel
  • J Barrios
  • L Sarmiento
  • I Avalos
  • J A Bravo
  • R Palomera
  • M Bello
  • R W Sutter
  • M A Pallansch
  • C A de Quadros

Summary, in English

BACKGROUND: With substantial progress made toward polio eradication, developing the appropriate strategy for discontinuing global oral poliovirus vaccine (OPV) after global eradication becomes increasingly important. At issue is the theoretical risk of independent circulation of potentially virulent OPV-derived strains. Because Cuba uses OPV only in mass campaigns, it represents an ideal site to assess vaccine-derived poliovirus persistence.

METHODS: Infants born after the 1997 biannual mass campaigns were evaluated for past (neutralizing antibody) or current (virus excretion) evidence of vaccine-derived poliovirus exposure. We obtained sera and/or stool specimens from 861 infants; a second serum from 218 infants.

RESULTS: All stool specimens were poliovirus negative. Of 762 infants, 113 (14.8%) had initially detectable poliovirus type 1 antibody, 193 (25.3%) type 2, and 94 (12.3%) type 3. A precipitous antibody decline occurred in initially positive sera.

CONCLUSIONS: Our results suggest that in a country with high population immunity, vaccine-derived virus is unlikely to establish ongoing circulation.

Publishing year

2001-10

Language

English

Pages

1029-1034

Publication/Series

International Journal of Epidemiology

Volume

30

Issue

5

Document type

Journal article

Publisher

Oxford University Press

Topic

  • Infectious Medicine
  • Public Health, Global Health, Social Medicine and Epidemiology

Keywords

  • Cuba/epidemiology
  • Global Health
  • Humans
  • Immunization Programs
  • Infant
  • Infant, Newborn
  • Poliomyelitis/epidemiology
  • Poliovirus Vaccine, Oral

Status

Published

ISBN/ISSN/Other

  • ISSN: 0300-5771