The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here:

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Default user image.

Luis Sarmiento-Pérez

Assistant researcher

Default user image.

Cambios geneticos en cepas de poliovirus tipo 2 aisladas de pacientes con poliomielitis paralitica asociada a la vacuna

Genetic changes in strains of poliovirus type 2 isolated from patients with vaccine-associated paralytic poliomyelitis


  • R Y Sosa-Díaz
  • P Más-Lago
  • O Valdés-Ramírez
  • L Sarmiento-Pérez

Summary, in English

INTRODUCTION: Poliomyelitis is currently a rare disease in developed countries, where only vaccinal strains seem to be in circulation, which replace wild poliovirus. Nevertheless, it is still a serious disease for children in underdeveloped countries of Asia and Africa.

PATIENTS AND METHODS: We analysed nine strains of poliovirus type 2 isolated from the faecal matter of patients with vaccine associated paralytic poliomyelitis (VAPP), from the beginning of anti polio vaccination campaigns in our country. These strains were submitted to sequencing of a fragment of 114 base pairs from the 5 NTR (non traductional region), where one of the main determinants of attenuation/reversion to the neurovirulence of poliovirus lies in the position of nucleotide 481.

RESULTS: In this position it was observed how guanine had been replaced by adenine in all the strains that were sequenced, so that it coincided with the homologous sequence of the wild strain, as well as with that of strains obtained from healthy children immunised with the live vaccine. This presupposes that other changes must occur or that other factors must be involved for VAPP to occur or not, and we therefore suggest the sequencing of other regions of the genome in search of other possible differential changes in nucleotides.

Publishing year







Revista de Neurologia





Document type

Journal article


Revista de Neurologia


  • Microbiology in the medical area


  • Child
  • Child, Preschool
  • Humans
  • Point Mutation/genetics
  • Poliomyelitis, Bulbar/prevention & control
  • Poliovirus/genetics
  • Poliovirus Vaccine, Oral/administration & dosage
  • Reverse Transcriptase Polymerase Chain Reaction
  • Vaccines, Attenuated/administration & dosage




  • ISSN: 0210-0010