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Luis Sarmiento-Pérez

Assistant researcher

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Islet cell related antibodies and type 1 diabetes associated with echovirus 30 epidemic : a case report

Author

  • Eduardo Cabrera-Rode
  • Luis Sarmiento
  • Gisela Molina
  • Cecilia Pérez
  • Celeste Arranz
  • José A Galvan
  • Mirta Prieto
  • Julio Barrios
  • Rosa Palomera
  • Magile Fonseca
  • Pedro Mas
  • Oscar Díaz-Horta
  • Oscar Diaz-Diaz

Summary, in English

Type 1 diabetes associated genes account for less than 50% of disease susceptibility. Human enteroviruses have been implicated as environmental factors that might trigger and/or accelerate this autoimmune disorder. We now report of a 12-year-old girl that developed pancreatic autoimmunity and type 1 diabetes after enteroviral infection. Diabetes-associated autoimmunity was evaluated by measurement of several islet cell related autoantibodies. Neutralizing antibodies to different enteroviruses were determined in the case and eight children suffering from aseptic meningitis during a large scale epidemic. Several types of diabetes-associated antibodies were detected post-infection in the adolescent with newly diagnosed type 1 diabetes, including islet cell antibodies (ICA) and tyrosine phosphatase antibodies (IA2A). ICA but not IA2A appeared in the non-diabetic enterovirus-infected subjects. Based on virological studies, type 1 diabetes pathogenesis process could have been triggered by echovirus 30 infections. This study provides the first evidence of an association between echovirus 30 infection with the presence of pancreatic autoimmunity and type 1 diabetes. Our data suggest that echovirus 30 Cuban strain could be considered a potentially diabetogenic enteroviral variant.

Publishing year

2005-07

Language

English

Pages

7-373

Publication/Series

Journal of Medical Virology

Volume

76

Issue

3

Document type

Journal article

Publisher

John Wiley and Sons

Topic

  • Medical and Health Sciences

Keywords

  • Adolescent
  • Arthritis, Infectious/blood
  • Autoantibodies/blood
  • Child
  • Child, Preschool
  • Cuba
  • Diabetes Mellitus, Type 1/etiology
  • Enterovirus Infections/complications
  • Female
  • Humans
  • Infant
  • Islets of Langerhans/immunology
  • Male
  • Neutralization Tests

Status

Published

ISBN/ISSN/Other

  • ISSN: 0146-6615