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Luis Sarmiento-Pérez

Assistant researcher

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Ausencia de circulación de poliovirus en departamentos colombianos con coberturas vacunales inferiores a 80%

Absence of poliovirus circulation in Colombian departments with vaccination coverage below 80%

Author

  • María Mercedes González
  • Luis Sarmiento
  • Gloria Janneth Rey-Benito
  • Leonardo Padilla
  • Alejandra María Giraldo
  • Jhon Carlos Castaño

Summary, in English

This study aims to explore a possible silent circulation of wild and vaccine-derived polioviruses in departments of Colombia with polio vaccination coverage of below 80%. The study collected 52 samples of wastewater concentrated as a result of precipitation with polyethylene glycol and sodium chloride. The viral detection was carried out through isolation and the identification through neutralization of the cytopathic effect, as well as through a conventional polymerase chain reaction following reverse transcription. The isolated polioviruses were characterized by the VP1 gene sequence. In two of the 52 samples, there was a presence of the Sabin type 2 poliovirus with more than 99% sequence similarity with the Sabin type 2 strain polio. Circulation of the nonpolio enterovirus was detected in 17.3% of the samples. The serotypes identified corresponded to coxsackievirus B1, echovirus 30, and echovirus 11. No evidence of the spread of either vaccine-derived poliovirus or wild poliovirus was detected in the departments of Colombia with polio coverage lower than 80%.

Publishing year

2012-08

Language

Spanish

Pages

60-156

Publication/Series

Revista panamericana de salud publica = Pan American journal of public health

Volume

32

Issue

2

Document type

Journal article

Publisher

Pan American Health Organization

Topic

  • Medical and Health Sciences

Keywords

  • Animals
  • Cell Line
  • Colombia
  • Enterovirus/classification
  • Humans
  • Mice
  • Poliovirus/classification
  • Poliovirus Vaccine, Oral
  • Serotyping
  • Vaccination/statistics & numerical data
  • Virus Cultivation
  • Waste Water/virology

Status

Published

ISBN/ISSN/Other

  • ISSN: 1020-4989