Your browser has javascript turned off or blocked. This will lead to some parts of our website to not work properly or at all. Turn on javascript for best performance.

The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Default user image.

Luis Sarmiento-Pérez

Assistant researcher

Default user image.

Molecular characterization of adenoviral infections in Cuba : report of an unusual association of species D adenoviruses with different clinical syndromes

Author

  • Acosta Belsy
  • Valdés Odalys
  • Piñón Alexander
  • Savón Clara
  • Goyenechea Angel
  • Gonzalez Grehete
  • Gonzalez Guelsys
  • Sarmiento Luis
  • Más Pedro
  • Guzmán María Guadalupe
  • Llop Alina
  • Perez Breña Ma Pilar
  • Casas Inmaculada

Summary, in English

Adenoviruses are common pathogens that are responsible for a wide variety of infectious syndromes. The objectives of this study were to identify and characterize members of different adenovirus species at the molecular level and to describe the correlation between viruses and clinical syndromes during a period of 4 years. Between 2002 and 2006, 45 of 512 respiratory specimens (8%) from patients with acute respiratory tract infection tested positive for adenovirus. Four adenovirus isolates from samples sent for enterovirus isolation were also analyzed. This research identified 49 confirmed cases of human adenovirus infection by PCR and/or viral culture. The most common diagnosis was upper respiratory infection (44%). Human adenovirus D was the major species found (59%), followed by Human adenovirus C (36%) and Human adenovirus B (4%). Human adenovirus 5 was the major serotype found producing bronchiolitis, followed by human adenovirus 6. In patients with upper respiratory infection, the major serotype found was human adenovirus 17. Viruses of the species Human adenovirus D were identified in seven (77%) cases of acute febrile syndrome. Four isolates from clinical materials obtained from patients with encephalitis, acute flaccid paralysis and meningoencephalitis were identified as belonging to the species Human adenovirus D. Our data demonstrate a surprising result about the identification of an unusual association of viruses of the species Human adenovirus D with different clinical syndromes. This observation could be evaluated as a possible indicator of the emergence of a novel strain but further studies are required.

Publishing year

2009

Language

English

Pages

27-619

Publication/Series

Archives of Virology

Volume

154

Issue

4

Document type

Journal article

Publisher

Springer

Topic

  • Infectious Medicine

Keywords

  • Adenoviridae Infections/virology
  • Adenoviruses, Human/classification
  • Adolescent
  • Adult
  • Bronchiolitis/virology
  • Child
  • Child, Preschool
  • Cuba
  • Encephalitis, Viral/virology
  • Female
  • Fever of Unknown Origin/virology
  • Humans
  • Infant
  • Male
  • Middle Aged
  • Paralysis/virology
  • Respiratory Tract Infections/virology
  • Young Adult

Status

Published

ISBN/ISSN/Other

  • ISSN: 1432-8798