The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

ludc webb

Lena Sundius

Biomedical analyst

ludc webb

Use of Lung Weight as Biomarker for Assessment of Lung Toxicity in Rat Inhalation Studies

Author

  • Erik Wahlstrom
  • Anna Ollerstam
  • Lena Sundius
  • Hui Zhang

Summary, in English

Subacute inhalation study (1 week or 2 weeks) is an important process for screening out inhaled compounds causing lung irritation. To investigate whether the lung weight can be used as an indicator for acute lung injury, we have analyzed retrospectively the lung weight data from 30 studies in rats exposed to dry powder inhalation. The lung weight change was correlated with lung histopathology in the majority of studies (25 of 30), showing as either both changed or both unchanged. The sensitivity and specificity of using the weight change in lungs as biomarker for predicting lung histopathology in these studies were over 80%. The pattern of lung weight change was often similar in the 1- to 2- week studies and the 4-week studies. Our analysis of covariance model showed that a study with 40 rats (5 males + 5 females/group and 4 groups) could detect lung weight change greater than 10% to 20% of control value. These results suggested that lung weight is a useful indicator for identifying acute lung toxic effect by inhaled compounds in these subacute inhalation studies.

Department/s

  • Cardiovascular Research - Immunity and Atherosclerosis

Publishing year

2013

Language

English

Pages

902-912

Publication/Series

Toxicologic Pathology

Volume

41

Issue

6

Document type

Journal article

Publisher

SAGE Publications

Topic

  • Pharmacology and Toxicology

Keywords

  • Inhalation
  • lung weight
  • lung histopathology
  • toxicology
  • statistical
  • analysis
  • biomarkers
  • rat

Status

Published

Research group

  • Cardiovascular Research - Immunity and Atherosclerosis

ISBN/ISSN/Other

  • ISSN: 0192-6233