Lena Eliasson
Principal investigator
Serotonin (5-HT) receptor 2b activation augments glucose-stimulated insulin secretion in human and mouse islets of Langerhans.
Author
Summary, in English
The Gq-coupled 5-hydroxytryptamine 2B (5-HT2B) receptor is known to regulate the proliferation of islet beta cells during pregnancy. However, the role of serotonin in the control of insulin release is still controversial. The aim of the present study was to explore the role of the 5-HT2B receptor in the regulation of insulin secretion in mouse and human islets, as well as in clonal INS-1(832/13) cells.
Department/s
- Celiac Disease and Diabetes Unit
- Diabetes - Islet Cell Exocytosis
- Diabetes - Molecular Metabolism
- Genomics, Diabetes and Endocrinology
- Neuroendocrine Cell Biology
- Stem Cell Center
- EXODIAB: Excellence of Diabetes Research in Sweden
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy
Publishing year
2016-01-06
Language
English
Pages
744-754
Publication/Series
Diabetologia
Volume
59
Issue
4
Links
Document type
Journal article
Publisher
Springer
Topic
- Endocrinology and Diabetes
Status
Published
Research group
- Celiac Disease and Diabetes Unit
- Diabetes - Islet Cell Exocytosis
- Diabetes - Molecular Metabolism
- Genomics, Diabetes and Endocrinology
- Neuroendocrine Cell Biology
ISBN/ISSN/Other
- ISSN: 1432-0428