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Lena Eliasson

Principal investigator

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Differential Glucose-Regulation of MicroRNAs in Pancreatic Islets of Non-Obese Type 2 Diabetes Model Goto-Kakizaki Rat.

Author

  • Jonathan Esguerra
  • Caroline Bolmeson
  • Corrado Cilio
  • Lena Eliasson

Summary, in English

The Goto-Kakizaki (GK) rat is a well-studied non-obese spontaneous type 2 diabetes (T2D) animal model characterized by impaired glucose-stimulated insulin secretion (GSIS) in the pancreatic beta cells. MicroRNAs (miRNAs) are short regulatory RNAs involved in many fundamental biological processes. We aim to identify miRNAs that are differentially-expressed in the pancreatic islets of the GK rats and investigate both their short- and long term glucose-dependence during glucose-stimulatory conditions.

Department/s

  • Diabetes - Islet Cell Exocytosis
  • Create Health
  • Evolutionary ecology
  • Diabetes - Immunovirology
  • EXODIAB: Excellence of Diabetes Research in Sweden

Publishing year

2011

Language

English

Publication/Series

PLoS ONE

Volume

6

Issue

4

Document type

Journal article

Publisher

Public Library of Science

Topic

  • Endocrinology and Diabetes

Keywords

  • Islets of Langerhans/*drug effects/*metabolism
  • MicroRNAs/*genetics
  • Glucose/*pharmacology
  • Gene Expression Profiling
  • Animals
  • Type 2/*metabolism
  • Diabetes Mellitus
  • Polymerase Chain Reaction
  • Rats
  • Wistar

Status

Published

Research group

  • Diabetes - Islet Cell Exocytosis
  • Diabetes - Immunovirology

ISBN/ISSN/Other

  • ISSN: 1932-6203