Lena Eliasson
Principal investigator
Lena Eliasson is appointed Professor in Experimental Diabetes Research at Lund University since 2011 and she is part of Lund University Diabetes Centre (LUDC). She has a Master in Engineering Physics, Chalmers Tehnical University in Gothenburg (1993) and a PhD in Cellular Physiology, Gothenburg University (1997). Her research aims to understand cellular mechanisms underlying impaired islet hormone secretion contributing to the pathogenesis of diabetes. The focus is on single cell physiology involving studies of ion-channels, exocytosis and non-coding RNA networks important in the regulation if islet cell secretion. She is leading in work concerning microRNA networks in islet cells for better treatment and diagnostics, and have several studies discussing the role of microRNAs in the regulation of islet cell function. ORCID:0000-0002-6467-5029
Publications
Displaying of publications. Sorted by year, then title.
Glucocorticoid-mediated induction of ZBTB16 affects insulin secretion in human islets and EndoC-βH1 β-cells
Alexandros Karagiannopoulos, Efraim Westholm, Jones K Ofori, Elaine Cowan, Jonathan L S Esguerra, et al.
(2023) iScience, 26 p.1-23
Journal articleInterleukin-4 reduces insulin secretion in human islets from healthy but not type-2 diabetic donors
Efraim Westholm, Anna Edlund, Alexandros Karagiannopoulos, Anna Wendt, Lena Eliasson
(2023) Biochemical and Biophysical Research Communications, 649 p.87-92
Journal articlemiRNAs in the beta cell - friends or foes?
Alexandros Karagiannopoulos, Elaine Cowan, Lena Eliasson
(2023) Endocrinology
Journal article reviewType 2 diabetes candidate genes, including PAX5, cause impaired insulin secretion in human pancreatic islets
Karl Bacos, Alexander Perfilyev, Alexandros Karagiannopoulos, Elaine Cowan, Jones K Ofori, et al.
(2023) The Journal of clinical investigation, 133
Journal articleSelectively bred rodent models for studying the etiology of type 2 diabetes : Goto-Kakizaki rats and Oikawa-Nagao mice
Mototsugu Nagao, Akira Asai, Lena Eliasson, Shinichi Oikawa
(2023) Endocrine Journal, 70 p.19-30
Journal article reviewMicroRNAs in Type 2 Diabetes : Focus on MicroRNA Profiling in Islets of Langerhans
Elaine Cowan, Alexandros Karagiannopoulos, Lena Eliasson
(2022) Methods in molecular biology (Clifton, N.J.) , p.113-142
Book chapterA critical role of the mechanosensor PIEZO1 in glucose-induced insulin secretion in pancreatic β-cells
Yingying Ye, Mohammad Barghouth, Haiqiang Dou, Cheng Luan, Yongzhi Wang, et al.
(2022) Nature Communications, 13
Journal articleEditorial : Special issue novel aspects of islet peptides
Lena Eliasson, Nils Wierup
(2022) Peptides, 157
Journal article (comment)The T-type calcium channel CaV3.2 regulates insulin secretion in the pancreatic β-cell
Mohammad Barghouth, Yingying Ye, Alexandros Karagiannopoulos, Yunhan Ma, Elaine Cowan, et al.
(2022) Cell Calcium, 108
Journal articlePancreatic alpha cells and glucagon secretion : Novel functions and targets in glucose homeostasis
Anna Wendt, Lena Eliasson
(2022) Current Opinion in Pharmacology, 63
Journal article reviewHuman pancreatic islet miRNA-mRNA networks of altered miRNAs due to glycemic status
Alexandros Karagiannopoulos, Jonathan LS Esguerra, Morten Pedersen, Anna Wendt, Rashmi Prasad, et al.
(2022) iScience, 25
Journal articleThe structure of insulin granule core determines secretory capacity being reduced in type-2 diabetes
Mohammad Barghouth, Xiaoping Jiang, Mototsugu Nagao, Ning Chen, Daowei Yang, et al.
(2022)
PreprintSecretory granule exocytosis and its amplification by cAMP in pancreatic β-cells
Mototsugu Nagao, Jens O. Lagerstedt, Lena Eliasson
(2022) Diabetology International, 13 p.471-479
Journal article reviewGlucocorticoids and glucolipotoxicity alter the DNA methylome and function of human EndoC-βH1 cells
Cristiane Dos Santos, Alexandros Karagiannopoulos, Alex Rafacho, Alexander Perfilyev, Lena Eliasson, et al.
(2022) Life Sciences, 307
Journal articleHuman Islet MicroRNA-200c Is Elevated in Type 2 Diabetes and Targets the Transcription Factor ETV5 to Reduce Insulin Secretion
Jones Ofori, Alexandros Karagiannopoulos, Mototsugu Nagao, Efraim Westholm, Shaima Ramadan, et al.
(2022) Diabetes, 71 p.275-284
Journal articleThe highly expressed calcium-insensitive synaptotagmin-11 and synaptotagmin-13 modulate insulin secretion
Jones K Ofori, Alexandros Karagiannopoulos, Mohammad Barghouth, Mototsugu Nagao, Markus E Andersson, et al.
(2022) Acta Physiologica, 236
Journal articleMAFA and MAFB regulate exocytosis-related genes in human β-cells
Rodrigo Cataldo, Tania Singh, Kavya Achanta, Sara Bsharat, Rashmi B Prasad, et al.
(2022) Acta Physiologica, 234
Journal articleOne more piece in the pancreatic chloride puzzle
Lena Eliasson
(2022) Acta Physiologica, 234
Journal article (comment)The Calcium Channel Subunit Gamma-4 as a Novel Regulator of MafA in Pancreatic Beta-Cell Controls Glucose Homeostasis
Rui Wu, Alexandros Karagiannopoulos, Lena Eliasson, Erik Renström, Cheng Luan, et al.
(2022) Biomedicines, 10
Journal articleGenetic regulation of RNA splicing in human pancreatic islets
Goutham Atla, Silvia Bonàs-Guarch, Mirabai Cuenca-Ardura, Anthony Beucher, Daniel J. M. Crouch, et al.
(2022) Genome Biology, 23 p.1-28
Journal articleThe human batokine EPDR1 regulates β-cell metabolism and function
Luis Rodrigo Cataldo, Qian Gao, Lidia Argemi-Muntadas, Ondrej Hodek, Elaine Cowan, et al.
(2022) Molecular Metabolism, 66
Journal articleEx vivo and in vivo experimental investigation of miR-148a-3p as a novel therapy for insulin secretion and type 2 diabetes
Elaine Cowan, Cheng Luan, Jones Ofori, Alexandros Karagiannopoulos, Jonathan LS Esguerra, et al.
(2022) Diabetologia, 65
Conference paper: abstractReplication study reveals miR-483-5p as an important target in prevention of cardiometabolic disease
Widet Gallo, Filip Ottosson, Cecilia Kennbäck, Amra Jujic, Jonathan LS Esguerra, et al.
(2021) BMC Cardiovascular Disorders, 21
Journal articleSCRT1 is a novel beta cell transcription factor with insulin regulatory properties
S. Chriett, A. Lindqvist, L. Shcherbina, A. Edlund, M. Abels, et al.
(2021) Molecular and Cellular Endocrinology, 521
Journal articleDiagnostic potential of miR-483 family for IGF-II producing non-islet cell tumor hypoglycemia
Mototsugu Nagao, Izumi Fukuda, Akira Asai, Jonathan L.S. Esguerra, Naomi Hizuka, et al.
(2021) European Journal of Endocrinology, 184 p.41-49
Journal articleIslet Function in the Pathogenesis of Cystic Fibrosis-Related Diabetes Mellitus
Efraim Westholm, Anna Wendt, Lena Eliasson
(2021) Clinical Medicine Insights: Endocrinology and Diabetes, 14 p.1-7
Journal article reviewDevelopment and validation of a quantitative electron microscopy score to assess acute cellular stress in the human exocrine pancreas
Nicole Kattner, Nicola Dyson, Yvonne Bury, Dina Tiniakos, Kathryn White, et al.
(2021) Journal of Pathology: Clinical Research, 7 p.173-187
Journal articleDifferential DNA Methylation and Expression of miRNAs in Adipose Tissue From Twin Pairs Discordant for Type 2 Diabetes
Emma Nilsson, Magdalena Vavakova, Alexander Perfilyev, Johanna Säll, Per-Anders Jansson, et al.
(2021) Diabetes, 70 p.2402-2418
Journal articleTIGER : The gene expression regulatory variation landscape of human pancreatic islets
Lorena Alonso, Anthony Piron, Ignasi Morán, Marta Guindo-Martínez, Sílvia Bonàs-Guarch, et al.
(2021) Cell Reports, 37
Journal articleNovel miR-29 mitochondrial-associated gene pathways predicted to regulate beta cell insulin secretion
Elaine Cowan, Jiangming Sun, Jones Ofori, Cheng Luan, Enming Zhang, et al.
(2021) Diabetologia, 64
Conference paper: abstractPancreatic α-cells – The unsung heroes in islet function
Anna Wendt, Lena Eliasson
(2020) Seminars in Cell and Developmental Biology, 103 p.41-50
Journal article reviewPotential Protection Against Type 2 Diabetes in Obesity Through Lower CD36 Expression and Improved Exocytosis in β-Cells
Mototsugu Nagao, Jonathan L S Esguerra, Akira Asai, Jones K Ofori, Anna Edlund, et al.
(2020) Diabetes, 69 p.1193-1205
Journal articleSelectively Bred Diabetes Models : GK Rats, NSY Mice, and ON Mice
Mototsugu Nagao, Jonathan Lou S Esguerra, Anna Wendt, Akira Asai, Hitoshi Sugihara, et al.
(2020) Methods in molecular biology (Clifton, N.J.), 2128 p.25-54
Book chapterApolipoprotein A-I primes beta cells to increase glucose stimulated insulin secretion
Oktawia Nilsson, Rita Del Giudice, Mototsugu Nagao, Caitriona Grönberg, Lena Eliasson, et al.
(2020) Biochimica et Biophysica Acta - Molecular Basis of Disease, 1866
Journal articleThe TCF7L2-dependent high-voltage activated calcium channel subunit α2δ-1 controls calcium signaling in rodent pancreatic beta-cells
Ye Yingying, Mohammad Barghouth, Cheng Luan, Abdulla Kazim, Yuedan Zhou, et al.
(2020) Molecular and Cellular Endocrinology, 502 p.1-11
Journal articleGlucocorticoid induces human beta cell dysfunction by involving riborepressor GAS5 LincRNA
Jonathan L.S. Esguerra, Jones K. Ofori, Mototsugu Nagao, Yuki Shuto, Alexandros Karagiannopoulos, et al.
(2020) Molecular Metabolism, 32 p.160-167
Journal articleExposure to maternal obesity programs sex differences in pancreatic islets of the offspring in mice
Lisa M Nicholas, Mototsugu Nagao, Laura C Kusinski, Denise S Fernandez-Twinn, Lena Eliasson, et al.
(2020) Diabetologia, 63 p.324-337
Journal articleSomatostatin secretion by Na+-dependent Ca2+-induced Ca2+ release in pancreatic delta cells
Elisa Vergari, Geoffrey Denwood, Albert Salehi, Quan Zhang, Julie Adam, et al.
(2020) Nature Metabolism, 2 p.32-40
Journal article (letter)A circular RNA generated from an intron of the insulin gene controls insulin secretion
Lisa Stoll, Adriana Rodríguez-Trejo, Claudiane Guay, Flora Brozzi, Mustafa Bilal Bayazit, et al.
(2020) Nature Communications, 11
Journal articleMicroRNA networks in pancreatic islet cells : Normal function and type 2 diabetes
Lena Eliasson, Jonathan L.S. Esguerra
(2020) Diabetes, 69 p.804-812
Journal articleMicro(RNA) Management and Mismanagement of the Islet
Lena Eliasson, Romano Regazzi
(2020) Journal of Molecular Biology, 432 p.1419-1428
Journal article reviewGlucolipotoxicity alters insulin secretion via epigenetic changes in human islets
Elin Hall, Josefine Jönsson, Jones K. Ofori, Petr Volkov, Alexander Perfilyev, et al.
(2019) Diabetes, 68 p.1965-1974
Journal articleThe calcium channel subunit gamma-4 is regulated by MafA and necessary for pancreatic beta-cell specification
Cheng Luan, Ye Yingying, Tania Singh, Mohammad Barghouth, Lena Eliasson, et al.
(2019) Communications Biology, 2
Journal articleIn Vivo Silencing of MicroRNA-132 Reduces Blood Glucose and Improves Insulin Secretion
Roel Bijkerk, Jonathan L S Esguerra, Johanne H Ellenbroek, Yu Wah Au, Maaike A J Hanegraaf, et al.
(2019) Nucleic acid therapeutics, 29 p.67-72
Journal articleDefective exocytosis and processing of insulin in a cystic fibrosis mouse model
Anna Edlund, Mohammad Barghouth, Michael Huhn, Mia Abels, Jonathan Esguerra, et al.
(2019) Journal of Endocrinology, 241 p.45-57
Journal articleN1-methylnicotinamide is a signalling molecule produced in skeletal muscle coordinating energy metabolism
Kristoffer Ström, David Morales-Alamo, Filip Ottosson, Anna Edlund, Line Hjort, et al.
(2018) Scientific Reports, 8
Journal articleIslet microRNAs in health and type-2 diabetes
Anna Wendt, Jonathan LS Esguerra, Lena Eliasson
(2018) Current Opinion in Pharmacology, 43 p.46-52
Journal article reviewmiR-483-5p associates with obesity and insulin resistance and independently associates with new onset diabetes mellitus and cardiovascular disease
Widet Gallo, Jonathan Lou S. Esguerra, Lena Eliasson, Olle Melander
(2018) PLoS ONE, 13
Journal articleMicroRNAs in islet hormone secretion
Jonathan L.S. Esguerra, Mototsugu Nagao, Jones K. Ofori, Anna Wendt, Lena Eliasson
(2018) Diabetes, Obesity and Metabolism, 20 p.11-19
Journal article reviewMC1568 improves insulin secretion in islets from type 2 diabetes patients and rescues β-cell dysfunction caused by Hdac7 upregulation
Mahboubeh Daneshpajooh, Lena Eliasson, Karl Bacos, Charlotte Ling
(2018) Acta Diabetologica, 55 p.1231-1235
Journal articleShe is in science to stay!
B. Birnir, L. Eliasson
(2018) Acta Physiologica, 223 p.13048-13048
Journal article (comment)MiR-335 overexpression impairs insulin secretion through defective priming of insulin vesicles
Vishal A. Salunkhe, Jones K. Ofori, Nikhil R. Gandasi, Sofia A. Salö, Sofia Hansson, et al.
(2017) Physiological Reports, 5
Journal articleGlucotoxicity-induced upregulation of lincRNA GAS5 in the pancreatic islets of type 2 diabetes donors and in Goto-Kakizaki rats
J. L. S. Esguerra, J. Ofori, M. Nagao, J. Fadista, L. Groop, et al.
(2017) Diabetologia, 60 p.22-23
Conference paper: abstractReduced insulin secretion in a diet-induced glucose intolerance susceptible mouse model is coupled with increased CD36 and triglycerides in the beta cells
A. Asai, M. Nagao, T. Tsuduki, T. Miyazawa, J. L. S. Esguerra, et al.
(2017) , p.61-61
Conference paper: abstractCD36 is increased in human islets from obese type 2 diabetes donors, and affects beta cell function by the modulation of exocytotic proteins and insulin content
M. Nagao, J. L. S. Esguerra, J. K. Ofori, A. Wendt, A. Asai, et al.
(2017) Diabetologia, 60 p.185-186
Conference paper: abstractIdentification of islet-enriched long non-coding RNAs contributing to β-cell failure in type 2 diabetes
Anna Motterle, Sonia Gattesco, Marie Line Peyot, Jonathan Lou S. Esguerra, Ana Ruiz-Gomez, et al.
(2017) Molecular Metabolism, 6 p.1407-1418
Journal articlePIWI-interacting RNAs as novel regulators of pancreatic beta cell function
Imène Sarah Henaoui, Cécile Jacovetti, Ines Mollet, Claudiane Guay, Jonathan Sobel, et al.
(2017) Diabetologia, 60 p.1977-1986
Journal articleAn 'alpha-beta' of pancreatic islet microribonucleotides
Louise Torp Dalgaard, Lena Eliasson
(2017) International Journal of Biochemistry and Cell Biology, 88 p.208-219
Journal articleMitochondrial transcription factor B2 is essential for mitochondrial and cellular function in pancreatic β-cells
Lisa M. Nicholas, Bérengère Valtat, Anya Medina Benavente, Lotta Andersson, Mia Abels, et al.
(2017) Molecular Metabolism, 6 p.651-663
Journal articleConfluence does not affect the expression of miR-375 and its direct targets in rat and human insulin-secreting cell lines
Jones K Ofori, Helena A Malm, Ines G Mollet, Lena Eliasson, Jonathan Lou S Esguerra
(2017) PeerJ, 5
Journal articleSox5 regulates beta-cell phenotype and is reduced in type 2 diabetes
Annika Axelsson, T Mahdi, H A Nenonen, Tania Singh, S Hänzelmann, et al.
(2017) Nature Communications, 8 p.15652-15652
Journal articleReduced blood glucose through thyroid hormone degradation product
L. Eliasson
(2017) Acta Physiologica, 220 p.184-185
Journal articleElevated miR-130a/miR130b/miR-152 expression reduces intracellular ATP levels in the pancreatic beta cell
Jones K. Ofori, Vishal A. Salunkhe, Annika Bagge, Neelanjan Vishnu, Mototsugu Nagao, et al.
(2017) Scientific Reports, 7
Journal articleCFTR is involved in the regulation of glucagon secretion in human and rodent alpha cells
Anna Edlund, Morten Gram Pedersen, Andreas Lindqvist, Nils Wierup, Malin Flodström-Tullberg, et al.
(2017) Scientific Reports, 7 p.1-12
Journal articleThe small RNA miR-375 - a pancreatic islet abundant miRNA with multiple roles in endocrine beta cell function
Lena Eliasson
(2017) Molecular and Cellular Endocrinology, 456 p.95-101
Journal articleEndogenous beta-cell CART regulates insulin secretion and transcription of beta-cell genes
L Shcherbina, A Edlund, J L S Esguerra, M Abels, Y Zhou, et al.
(2017) Molecular and Cellular Endocrinology, 447 p.52-60
Journal articleErythropoietin and TRPV1 together in new formation
L. Eliasson
(2017) Acta Physiologica, 219 p.341-342
Journal article (comment)Neuron-enriched RNA-binding Proteins Regulate Pancreatic Beta Cell Function and Survival
Jon Agraves Juan-Mateu, Tatiana H Rech, Olatz Villate, Esther Lizarraga-Mollinedo, Anna Wendt, et al.
(2017) Journal of Biological Chemistry, 292 p.3466-3480
Journal articleWhole-genome Bisulfite Sequencing of Human Pancreatic Islets Reveals Novel Differentially Methylated Regions in Type 2 Diabetes Pathogenesis
Petr Volkov, Karl Bacos, Jones K Ofori, Jonathan Lou S Esguerra, Lena Eliasson, et al.
(2017) Diabetes, 66 p.1074-1085
Journal articleOsteopontin affects insulin vesicle localization and Ca2+ homeostasis in pancreatic beta cells from female mice
Anna Wendt, Ines Mollet, Anki Knutsson, Victor S. Bolmgren, Anna Hultgårdh, et al.
(2017) PLoS ONE, 12
Journal articleHDAC7 is overexpressed in human diabetic islets and impairs insulin secretion in rat islets and clonal beta cells
Mahboubeh Daneshpajooh, Karl Bacos, Madhusudhan Bysani, Annika Bagge, Emilia Ottosson Laakso, et al.
(2017) Diabetologia, 60 p.116-125
Journal articleLessons from basic pancreatic beta cell research in type-2 diabetes and vascular complications
Lena Eliasson, Jonathan Lou S. Esguerra, Anna Wendt
(2017) Diabetology International, 8 p.139-152
Journal article reviewInhibition of phosphodiesterase 3, 4, and 5 induces endolymphatic hydrops in mouse inner ear, as evaluated with repeated 9.4T MRI
Eva Degerman, Rene in 't Zandt, Ann-Kristin Holmén-Pålbrink, Lena Eliasson, Per Cayé-Thomasen, et al.
(2017) Acta Oto-Laryngologica, 137 p.8-15
Journal articleIntegrator of stress responses calmodulin binding transcription activator 1 (Camta1) Regulates miR-212/miR-132 Expression and insulin secretion
Inês Guerra Uerra Mollet, Helena Anna Malm, Anna Wendt, Marju Orho-Melander, Lena Eliasson
(2016) Journal of Biological Chemistry, 291 p.18440-18452
Journal articleDual Effect of Rosuvastatin on Glucose Homeostasis Through Improved Insulin Sensitivity and Reduced Insulin Secretion
Vishal A. Salunkhe, Ines Mollet, Jones K. Ofori, Helena A. Malm, Jonathan L S Esguerra, et al.
(2016) EBioMedicine, 10 p.185-194
Journal articleRosuvastatin treatment affects both basal and glucose-induced insulin secretion in INS-1 832/13 cells
Vishal A. Salunkhe, Olof Elvstam, Lena Eliasson, Anna Wendt
(2016) PLoS ONE, 11
Journal articleTranscriptional regulation of the miR-212/miR-132 cluster in insulin-secreting β-cells by cAMP-regulated transcriptional co-activator 1 and salt-inducible kinases.
Helena Malm, Ines Mollet, Christine Berggreen, Marju Orho-Melander, Jonathan Esguerra, et al.
(2016) Molecular and Cellular Endocrinology, 424 p.23-33
Journal articleCD46 Activation Regulates miR-150-Mediated Control of GLUT1 Expression and Cytokine Secretion in Human CD4+ T Cells.
Ben King, Jonathan Esguerra, Ewelina Golec, Lena Eliasson, Claudia Kemper, et al.
(2016) Journal of immunology, 196 p.1636-1645
Journal articleSerotonin (5-HT) receptor 2b activation augments glucose-stimulated insulin secretion in human and mouse islets of Langerhans.
Hedvig Bennet, Ines Mollet, Alexander Balhuizen, Anya Medina Benavente, Cecilia Nagorny, et al.
(2016) Diabetologia, 59 p.744-754
Journal articleBlood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes
Karl Bacos, Linn Gillberg, Petr Volkov, Anders H Olsson, Torben Hansen, et al.
(2016) Nature Communications, 7
Journal articleMiR-335 regulates exocytotic proteins and affects glucose-stimulated insulin secretion through decreased Ca2+-dependent exocytosis in beta cells
V.A. Salunkhe, J. Ofori, N.R. Gandasi, S.A. Salö, A. Wendt, et al.
(2015) Diabetologia, 58 p.128-128
Conference paper: abstractModulation of microRNA-375 expression alters voltage-gated Na(+) channel properties and exocytosis in insulin-secreting cells.
Vishal Ashok Salunkhe, Jonathan Esguerra, Jones Ofori, Ines Mollet, Matthias Braun, et al.
(2015) Acta Physiologica, 213 p.882-892
Journal articleMiR-184 regulates pancreatic β-cell function according to glucose metabolism.
Sudhir G Tattikota, Thomas Rathjen, Jean Hausser, Aditya Khedkar, Uma D Kabra, et al.
(2015) Journal of Biological Chemistry, 290 p.20284-20294
Journal articleBone morphogenetic protein 4 inhibits insulin secretion from rodent beta cells through regulation of calbindin1 expression and reduced voltage-dependent calcium currents
Gitte L. Christensen, Maria L. B. Jacobsen, Anna Wendt, Ines Mollet, Josefine Friberg, et al.
(2015) Diabetologia, 58 p.1282-1290
Journal articleExposure to bisphenol A, but not phthalates, increases spontaneous diabetes type 1 development in NOD mice
Johanna Bodin, Anette Kocbach Bølling, Anna Wendt, Lena Eliasson, Rune Becher, et al.
(2015) Toxicology Reports, 2 p.99-110
Journal articleMicroRNA-7a regulates pancreatic beta cell function
Mathieu Latreille, Jean Hausser, Ina Stuetzer, Quan Zhang, Benoit Hastoy, et al.
(2014) Journal of Clinical Investigation, 124 p.2722-2735
Journal articleSex differences in the genome-wide DNA methylation pattern and impact on gene expression, microRNA levels and insulin secretion in human pancreatic islets
Elin Hall, Petr Volkov, Tasnim Dayeh, Jonathan Esguerra, Sofia Salo, et al.
(2014) GenomeBiology, 15
Journal articleCalcium Current Inactivation Rather than Pool Depletion Explains Reduced Exocytotic Rate with Prolonged Stimulation in Insulin-Secreting INS-1 832/13 Cells.
Morten Gram Pedersen, Vishal Ashok Salunkhe, Emma Svedin, Anna Edlund, Lena Eliasson
(2014) PLoS ONE, 9
Journal articleGenome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion.
Tasnim Dayeh, Petr Volkov, Sofia Salö, Elin Hall, Emma A Nilsson, et al.
(2014) PLoS Genetics, 10
Journal articleGlobal genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism.
Joao Fadista, Petter Vikman, Emilia Ottosson Laakso, Ines Mollet, Jonathan Esguerra, et al.
(2014) Proceedings of the National Academy of Sciences, 111 p.13924-13929
Journal articleLoss of TFB1M results in mitochondrial dysfunction that leads to impaired insulin secretion and diabetes.
Vladimir Sharoyko, Mia Abels, Jiangming Sun, Lisa Nicholas, Ines Mollet, et al.
(2014) Human Molecular Genetics, 23 p.5733-5749
Journal articleNova1 is a master regulator of alternative splicing in pancreatic beta cells.
Olatz Villate, Jean-Valery Turatsinze, Loriana G Mascali, Fabio A Grieco, Tatiane C Nogueira, et al.
(2014) Nucleic Acids Research, 42 p.11818-11830
Journal articleRole of non-coding RNAs in pancreatic beta-cell development and physiology.
Lena Eliasson, Jonathan Esguerra
(2014) Acta Physiologica, 211 p.273-284
Journal article reviewArgonaute2 Mediates Compensatory Expansion of the Pancreatic β Cell.
Sudhir G Tattikota, Thomas Rathjen, Sarah J McAnulty, Hans-Hermann Wessels, Ildem Akerman, et al.
(2014) Cell Metabolism, 19 p.122-134
Journal articleMelatonin heals the gut
Lena Eliasson
(2014) Acta Physiologica, 212 p.120-121
Journal article (comment)Dynamic Magnetic Fields Remote-Control Apoptosis via Nanoparticle Rotation.
Enming Zhang, Moritz F Kircher, Martin Koch, Lena Eliasson, S Nahum Goldberg, et al.
(2014) ACS Nano, 8 p.3192-3201
Journal articleFunctional implications of long non-coding RNAs in the pancreatic islets of Langerhans.
Jonathan Esguerra, Lena Eliasson
(2014) Frontiers in Genetics, 5 p.1-9
Journal article reviewCFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells.
Anna Edlund, Jonathan Esguerra, Anna Wendt, Malin Flodström-Tullberg, Lena Eliasson
(2014) BMC Medicine, 12
Journal articleRegulation of Pancreatic Beta Cell Stimulus-Secretion Coupling by microRNAs.
Jonathan Esguerra, Ines Mollet, Vishal Ashok Salunkhe, Anna Wendt, Lena Eliasson
(2014) Genes, 5 p.1018-1031
Journal article reviewProgesterone metabolite influence feeding behaviour.
Anna Wendt, Lena Eliasson
(2013) Acta Physiologica, 208 p.296-297
Journal article (comment)Fast Surface Acoustic Wave-Matrix-Assisted Laser Desorption Ionization Mass Spectrometry of Cell Response from Islets of Langerhans.
Loreta Bllaci, Sven Kjellström, Lena Eliasson, James R Friend, Leslie Y Yeo, et al.
(2013) Analytical Chemistry, 85 p.2623-2629
Journal articleNew drug for treatment of insulin-resistant complication?
Lena Eliasson
(2013) Acta Physiologica, 207 p.432-433
Journal article (letter)CD46 costimulation leads to enhanced T cell activation and microrna expression
Benjamin C. King, Jonathan Esguerra, Munazza Qayyum, Lena Eliasson, Claudia Kemper, et al.
(2012) Immunobiology, 217 p.1148-1149
Conference paper: abstractSecreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes.
Taman Mahdi, Sonja Hänzelmann, S Albert Salehi, Sarheed Jabar Muhammed, Thomas Reinbothe, et al.
(2012) Cell Metabolism, 16 p.625-633
Journal articleReduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes.
Sofia A Andersson, Anders H Olsson, Jonathan L S Esguerra, Emilia Heimann, Claes Ladenvall, et al.
(2012) Molecular and Cellular Endocrinology, 364 p.36-45
Journal articleMultivesicular exocytosis in rat pancreatic beta cells
M. B. Hoppa, E. Jones, J. Karanauskaite, R. Ramracheya, M. Braun, et al.
(2012) Diabetologia, 55 p.1001-1012
Journal articleSynapsins I and II Are Not Required for Insulin Secretion from Mouse Pancreatic beta-cells
Anna Wendt, Dina Speidel, Anders Danielsson, Jonathan L. S. Esguerra, Inger Lise Bogen, et al.
(2012) Endocrinology, 153 p.2112-2119
Journal articleReduced Insulin Exocytosis in Human Pancreatic β-cells With Gene Variants Linked to Type 2 Diabetes.
Anders Rosengren, Matthias Braun, Taman Mahdi, Sofia A Andersson, Mary E Travers, et al.
(2012) Diabetes, 61 p.1726-1733
Journal articleGlucose-dependent docking and SNARE protein-mediated exocytosis in mouse pancreatic alpha-cell.
Sofia Andersson, Morten Gram Pedersen, Jenny Vikman, Lena Eliasson
(2011) Pflügers Archiv, 462 p.443-454
Journal articleElectrophysiology of pancreatic beta-cells in intact mouse islets of Langerhans
Patrik Rorsman, Lena Eliasson, Takahiro Kanno, Quan Zhang, Sven Gopel
(2011) Progress in Biophysics and Molecular Biology, 107 p.224-235
Journal article reviewMathematical modeling and statistical analysis of calcium-regulated insulin granule exocytosis in beta-cells from mice and humans.
Morten Gram Pedersen, Giuliana Cortese, Lena Eliasson
(2011) Progress in Biophysics and Molecular Biology, 107 p.257-264
Journal articleDifferences in islet-enriched miRNAs in healthy and glucose intolerant human subjects.
Caroline Bolmeson, Jonathan Esguerra, S Albert Salehi, Dina Speidel, Lena Eliasson, et al.
(2011) Biochemical and Biophysical Research Communications, Dec p.16-22
Journal articleDifferential Glucose-Regulation of MicroRNAs in Pancreatic Islets of Non-Obese Type 2 Diabetes Model Goto-Kakizaki Rat.
Jonathan Esguerra, Caroline Bolmeson, Corrado Cilio, Lena Eliasson
(2011) PLoS ONE, 6
Journal articleBeta-cell specific deletion of dicer1 leads to defective insulin secretion and diabetes mellitus.
Martins Kalis, Caroline Bolmeson, Jonathan Esguerra, Shashank Gupta, Anna Edlund, et al.
(2011) PLoS ONE, 6
Journal articlePleiotropic Effects of GIP on Islet Function Involve Osteopontin
Valeriya Lyssenko, Lena Eliasson, Olga Kotova, Kasper Pilgaard, Nils Wierup, et al.
(2011) Diabetes, 60 p.2424-2433
Journal articleGLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis.
Yang De Marinis, S Albert Salehi, Caroline E Ward, Quan Zhang, Fernando Abdulkader, et al.
(2010) Cell Metabolism, 11 p.543-553
Journal articleEnhancement of glucagon secretion in mouse and human pancreatic alpha cells by protein kinase C (PKC) involves intracellular trafficking of PKCalpha and PKCdelta.
Yang De Marinis, Enming Zhang, Stefan Amisten, Jalal Taneera, Erik Renström, et al.
(2010) Diabetologia, 53 p.717-729
Journal articleMicroRNA differences in human islets and glucose-sensitive tissues
Caroline Bolmeson, Jonathan Esguerra, Dina Speidel, Lena Eliasson, Corrado Cilio
(2010) Diabetologia, 53 p.527-527
Conference paper: abstractActive CFTR channels are important for insulin- and glucagon secretion
Anna Edlund, M. Huhn, M. Flodstrom-Tullberg, Lena Eliasson
(2010) Diabetologia, 53 p.557-557
Conference paper: abstractOverexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes.
Anders Rosengren, Ramunas Jokubka, Damon Tojjar, Charlotte Granhall, Ola Hansson, et al.
(2010) Science (New York, N.Y.), 327 p.217-220
Journal articleEvidence for PKA-independent priming of insulin secretory granules: insight from mathematical modeling
M. G. Pedersen, Lena Eliasson
(2009) Diabetologia, 52 p.443-443
Conference paper: abstractRapid changes in surface expression of L-type Cav1.2 channels in stimulated INS-1 cells
Enming Zhang, Thomas Reinbothe, Sofia A Andersson, Lena Eliasson, M. Brauns, et al.
(2009) Diabetologia, 52 p.436-436
Conference paper: abstractBoth rapid exocytosis and granule mobilization in glucagon secreting cells are reduced by antibodies against synaptosomal protein of 25 kDa (SNAP-25) and Syntaxin 1
Sofia A Andersson, Jenny Vikman, Lena Eliasson
(2009) Diabetologia, 52 p.442-442
Conference paper: abstractSuppression of sulfonylurea- and glucose-induced insulin secretion in vitro and in vivo in mice lacking the chloride transport protein ClC-3.
Dai-Qing Li, Xingjun Jing, S Albert Salehi, Stephan C Collins, Michael B Hoppa, et al.
(2009) Cell Metabolism, 10 p.309-315
Journal articleTruncation of SNAP-25 reduces the stimulatory action of cAMP on rapid exocytosis in insulin-secreting cells.
Jenny Vikman, Hjalmar Svensson, Ya-Chi Huang, Youhou Kang, Sofia A Andersson, et al.
(2009) American Journal of Physiology: Endocrinology and Metabolism, 297 p.452-461
Journal articleHyperactivity in adrenergic signalling via alpha2A receptors contributes to human type 2 diabetes
Anders Rosengren, Ramunas Jokubka, Damon Tojjar, Charlotte Granhall, Jonatan Tuncel, et al.
(2009) Diabetologia, 52 p.108-108
Conference paper: abstractDual effects of low and high concentrations of cAMP on glucagon secretion from mouse pancreatic A-cells
Lena Eliasson, Yang De Marinis, R. Ramracheya, S Albert Salehi, Enming Zhang, et al.
(2009) Diabetologia, 52 p.562-562
Conference paper: abstractPredicted targets of co-expressed microRNAs in pancreatic islets of GK rats are enriched for genes involved in regulation of beta cell mass and glucose-stimulated insulin secretion
Jonathan Esguerra, Caroline Bolmeson, Corrado Cilio, Lena Eliasson
(2009) Diabetologia, 52 p.391-391
Conference paper: abstractCell coupling in mouse pancreatic beta-cells measured in intact islets of Langerhans
Quan Zhang, Juris Galvanovskis, Fernando Abdulkader, Christopher J. Partridge, Sven O. Gopel, et al.
(2008) Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Science, 366 p.3503-3523
Journal articleCaV1.2 rather than CaV1.3 is coupled to glucose-stimulated insulin secretion in INS-1 832/13 cells.
Marloes Dekker Nitert, Cecilia Nagorny, Anna Wendt, Lena Eliasson, Hindrik Mulder
(2008) Journal of Molecular Endocrinology, 41 p.1-11
Journal articleNovel aspects of the molecular mechanisms controlling insulin secretion
Lena Eliasson, Fernando Abdulkader, Matthias Braun, Juris Galvanovskis, Michael B. Hoppa, et al.
(2008) Journal of Physiology, 586 p.3313-3324
Journal article reviewWhy treatment fails in type 2 diabetes.
Anders Rosengren, Xingjun Jing, Lena Eliasson, Erik Renström
(2008) PLoS Medicine, 5 p.1426-1427
Journal articleLack of cholesterol mobilization in islets of hormone-sensitive lipase deficient mice impairs insulin secretion.
Sara Larsson, Nils Wierup, Frank Sundler, Lena Eliasson, Cecilia Holm
(2008) Biochemical and Biophysical Research Communications, 376 p.558-562
Journal articleLong-term exposure of mouse pancreatic islets to oleate or palmitate results in reduced glucose-induced somatostatin and oversecretion of glucagon
S. C. Collins, S Albert Salehi, Lena Eliasson, C. S. Olofsson, P. Rorsman
(2008) Diabetologia, 51 p.1689-1693
Journal articleGLP-1 inhibits glucagon secretion by affecting several cellular mechanisms
Yang De Marinis, Q. Zhang, S Albert Salehi, Lena Eliasson, R. Rorsman
(2008) Diabetologia, 51 p.256-256
Conference paper: abstractLong-term exposure to glucose and lipids inhibits glucose-induced insulin secretion downstream of granule fusion with plasma membrane.
Charlotta Olofsson, Stephan Collins, Martin Bengtsson, Lena Eliasson, S Albert Salehi, et al.
(2007) Diabetes, 56 p.1888-1897
Journal articleA dominant mutation in Snap25 causes impaired vesicle trafficking, sensorimotor gating, and ataxia in the blind-drunk mouse
Alexander F. Jeans, Peter L. Oliver, Reuben Johnson, Marco Capogna, Jenny Vikman, et al.
(2007) Proceedings of the National Academy of Sciences, 104 p.2431-2436
Journal articlebeta-cell PDE3B regulates Ca(2+)-stimulated exocytosis of insulin.
Helena Jones, Nils Wierup, Jenny Vikman, Vincent C Manganiello, Eva Degerman, et al.
(2007) Cellular Signalling, 19 p.1505-1513
Journal articleA K-ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of langerhans
Patrick E. MacDonald, Yang Zhang De Marinis, Reshma Ramracheya, S Albert Salehi, Xiaosong Ma, et al.
(2007) PLoS Biology, 5 p.1236-1247
Journal articleR-type Ca2+-channel-evoked CICR regulates glucose-induced somatostatin secretion
Quan Zhang, Martin Bengtsson, Chris Partridge, S Albert Salehi, Matthias Braun, et al.
(2007) Nature Cell Biology, 9 p.171-453
Journal articleSecretory and electrophysiological characteristics of insulin cells from gastrectomized mice: Evidence for the existence of insulinotropic agents in the stomach.
S Albert Salehi, Lena Eliasson, Xiaosong Ma, Patrik Rorsman, Rolf Håkanson, et al.
(2007) Regulatory Peptides, 139 p.31-38
Journal articleAntibody inhibition of synaptosomal protein of 25 kDa (SNAP-25) and syntaxin 1 reduces rapid exocytosis in insulin-secreting cells.
Jenny Vikman, Xiaosong Ma, Gregory H Hockerman, Patrik Rorsman, Lena Eliasson
(2006) Journal of Molecular Endocrinology, 36 p.503-515
Journal articleCalcium increases endocytotic vesicle size and accelerates membrane fission in insulin-secreting INS-1 cells.
Patrick MacDonald, Lena Eliasson, Patrik Rorsman
(2005) Journal of Cell Science, 118 p.5911-5920
Journal articleRegulated Exocytosis and Kiss-and-Run of Synaptic-Like Microvesicles in INS-1 and Primary Rat {beta}-Cells.
Patrick MacDonald, Stefanie Obermüller, Jenny Vikman, Juris Galvanovskis, Patrik Rorsman, et al.
(2005) Diabetes, 54 p.736-743
Journal articleAdenovirus-mediated silencing of Synaptotagmin 9 inhibits Ca2+-dependent insulin secretion in islets
M Iezzi, Lena Eliasson, M Fukuda, C B Wollheim
(2005) FEBS Letters, 579 p.5241-5246
Journal articleGlucagon stimulates exocytosis in mouse and rat pancreatic {alpha} cells by binding to glucagon receptors.
Xiaosong Ma, Yang De Marinis, Jesper Gromada, Sabine Sewing, Per-Olof Berggren, et al.
(2005) Molecular Endocrinology, 19 p.198-212
Journal articleSomatostatin, misoprostol and galanin inhibit gastrin- and PACAP-stimulated secretion of histamine and pancreastatin from ECL cells by blocking specific Ca(2+) channels.
Maria Björkqvist, Maria Lundgren, Lena Eliasson, Rolf Håkanson, Erik Lindström
(2005) Regulatory Peptides, 130 p.81-90
Journal articleThe first gamma-carboxyglutamic acid-containing contryphan - A selective L-type calcium ion channel blocker isolated from the venom of conus marmoreus
Karin M Hansson, Xiaosong Ma, Lena Eliasson, Eva Czerwiec, Bruce Furie, et al.
(2004) Journal of Biological Chemistry, 279 p.32453-32463
Journal articleCapacitance measurements of exocytosis in mouse pancreatic {alpha}-, {beta}- and {delta}-cells studied in intact islets of Langerhans.
Sven Göpel, Quan Zhang, Lena Eliasson, Xiaosong Ma, Juris Galvanovskis, et al.
(2004) Journal of Physiology, 556 p.711-726
Journal articleA pancreatic islet-specific microRNA regulates insulin secretion
MN Poy, Lena Eliasson, J Krutzfeldt, S Kuwajima, Xiaosong Ma, et al.
(2004) Nature, 432 p.226-230
Journal articleLarge dense-core vesicle exocytosis in pancreatic beta-cells monitored by capacitance measurements
T Kanno, Xiaosong Ma, Sebastian Barg, Lena Eliasson, Juris Galvanovskis, et al.
(2004) Methods, 33 p.302-311
Journal articleRequirement for N-ethylmaleimide-sensitive factor for exocytosis of insulin-containing secretory granules in pancreatic beta-cells.
Jenny Vikman, Xiaosong Ma, M Tagaya, Lena Eliasson
(2003) Biochemical Society Transactions, 31 p.842-847
Journal articleSUR1 Regulates PKA-independent cAMP-induced Granule Priming in Mouse Pancreatic B-cells.
Lena Eliasson, Xiaosong Ma, Erik Renström, Sebastian Barg, Per-Olof Berggren, et al.
(2003) Journal of General Physiology, 121 p.181-197
Journal articleFast insulin secretion reflects exocytosis of docked granules in mouse pancreatic B-cells.
Charlotta Olofsson, Sven Göpel, Sebastian Barg, Juris Galvanovskis, Xiaosong Ma, et al.
(2002) Pflügers Archiv, 444 p.43-51
Journal articleA Subset of 50 Secretory Granules in Close Contact With L-Type Ca(2+) Channels Accounts for First-Phase Insulin Secretion in Mouse beta-Cells.
Sebastian Barg, Lena Eliasson, Erik Renström, Patrik Rorsman
(2002) Diabetes, 51 Suppl 1 p.74-82
Journal articlePriming of insulin granules for exocytosis by granular Cl(-) uptake and acidification
Sebastian Barg, P Huang, Lena Eliasson, D J Nelson, Stefanie Obermüller, et al.
(2001) Journal of Cell Science, 114 p.2145-2154
Journal articleFast exocytosis with few Ca(2+) channels in insulin-secreting mouse pancreatic B cells
Sebastian Barg, Xiaosong Ma, Lena Eliasson, Juris Galvanovskis, Sven Göpel, et al.
(2001) Biophysical Journal, 81 p.3308-3323
Journal articleGastrin and the neuropeptide PACAP evoke secretion from rat stomach histamine-containing (ECL) cells by stimulating influx of Ca2+ through different Ca2+ channels
Erik Lindström, Lena Eliasson, Maria Björkqvist, Rolf Håkanson
(2001) Journal of Physiology, 535 p.663-677
Journal articleTight coupling between electrical activity and exocytosis in mouse glucagon-secreting alpha-cells
Sebastian Barg, J Galvanovskis, S O Gopel, Patrik Rorsman, Lena Eliasson
(2000) Diabetes, 49 p.1500-1510
Journal articleThe Cell Physiology of Biphasic Insulin Secretion
Patrik Rorsman, Lena Eliasson, Erik Renström, Jesper Gromada, Sebastian Barg, et al.
(2000) News in Physiological Sciences, 15 p.72-77
Journal articleCaM kinase II-dependent mobilization of secretory granules underlies acetylcholine-induced stimulation of exocytosis in mouse pancreatic B-cells
Jesper Gromada, Marianne Hoy, Erik Renström, Krister Bokvist, Lena Eliasson, et al.
(1999) Journal of Physiology, 518 p.745-759
Journal articleThe stimulatory action of tolbutamide on Ca2+-dependent exocytosis in pancreatic beta cells is mediated by a 65-kDa mdr-like P-glycoprotein
Sebastian Barg, Erik Renström, P O Berggren, A Bertorello, K Bokvist, et al.
(1999) Proceedings of the National Academy of Sciences, 96 p.5539-5544
Journal articleActivation of Ca(2+)-dependent K(+) channels contributes to rhythmic firing of action potentials in mouse pancreatic beta cells
Sven Göpel, Takahiro Kanno, Sebastian Barg, Lena Eliasson, Juris Galvanovskis, et al.
(1999) Journal of General Physiology, 114 p.759-770
Journal articleComponents of insulin secretion: lessons to be learnt from capacitance
Patrik Rorsman, Lena Eliasson, Erik Renström
(1997) Japanese Journal of Physiology, 47 p.21-21
Journal articleProtein kinase A-dependent and -independent stimulation of exocytosis by cAMP in mouse pancreatic B-cells
Erik Renström, Lena Eliasson, Patrik Rorsman
(1997) Journal of Physiology, 502 p.105-118
Journal articleRapid ATP-dependent priming of secretory granules precedes Ca(2+)-induced exocytosis in mouse pancreatic B-cells
Lena Eliasson, Erik Renström, W G Ding, P Proks, Patrik Rorsman
(1997) Journal of Physiology, 503 p.399-412
Journal articleCooling inhibits exocytosis in single mouse pancreatic B-cells by suppression of granule mobilization
Erik Renström, Lena Eliasson, Krister Bokvist, Patrik Rorsman
(1996) Journal of Physiology, 494 p.41-52
Journal articleCo-localization of L-type Ca2+ channels and insulin-containing secretory granules and its significance for the initiation of exocytosis in mouse pancreatic B-cells
K Bokvist, Lena Eliasson, C Ammala, Erik Renström, Patrik Rorsman
(1995) EMBO Journal, 14 p.50-57
Journal articleExocytosis elicited by action potentials and voltage-clamp calcium currents in individual pancreatic B-cells
C. Ämmälä, L. Eliasson, K Bokvist, O. Larsson, F. M. Ashcroft, et al.
(1993) The Journal of Physiology, 472 p.665-688
Journal article