The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Leif Groop

Leif Groop

Principal investigator

Leif Groop

A non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population

Author

  • Caroline Brorsson
  • Regine Bergholdt
  • Marketa Sjögren
  • Stefanie Eising
  • Karina Meden Sorensen
  • David M. Hougaard
  • Marju Orho-Melander
  • Leif Groop
  • Flemming Pociot

Summary, in English

Genome-wide association scans in type 2 diabetes (T2D) have identified a risk variant, rs13266634 (Arg325Trp), in SLC30A8 on chromosome 8. SLC30A8 encodes a beta-cell specific zinc-ion transporter and rs13266634 has been shown to affect insulin secretion. Recently, autoantibodies for Slc30A8 with high predictive value were demonstrated in individuals with type 1 diabetes (T1 D), making this gene an interesting T1 D candidate gene. We genotyped rs13266634 in 3008 cases and controls and 246 families from Denmark. Association to T1 D could not be demonstrated.

Department/s

  • Genomics, Diabetes and Endocrinology

Publishing year

2008

Language

English

Pages

386-388

Publication/Series

Molecular Genetics and Metabolism

Volume

94

Issue

3

Document type

Journal article

Publisher

Elsevier

Topic

  • Endocrinology and Diabetes

Keywords

  • beta-cell function
  • genetics
  • type 1 diabetes
  • SLC30A8
  • zinc transporter

Status

Published

Research group

  • Genomics, Diabetes and Endocrinology

ISBN/ISSN/Other

  • ISSN: 1096-7192