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Leif Groop

Leif Groop

Principal investigator

Leif Groop

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

Author

  • Benjamin F. Voight
  • Laura J. Scott
  • Valgerdur Steinthorsdottir
  • Andrew P. Morris
  • Christian Dina
  • Ryan P. Welch
  • Eleftheria Zeggini
  • Cornelia Huth
  • Yurii S. Aulchenko
  • Gudmar Thorleifsson
  • Laura J. McCulloch
  • Teresa Ferreira
  • Harald Grallert
  • Najaf Amin
  • Guanming Wu
  • Cristen J. Willer
  • Soumya Raychaudhuri
  • Steve A. McCarroll
  • Claudia Langenberg
  • Oliver M. Hofmann
  • Josee Dupuis
  • Lu Qi
  • Ayellet V. Segre
  • Mandy van Hoek
  • Pau Navarro
  • Kristin Ardlie
  • Beverley Balkau
  • Rafn Benediktsson
  • Amanda J. Bennett
  • Roza Blagieva
  • Eric Boerwinkle
  • Lori L. Bonnycastle
  • Kristina Bengtsson Bostrom
  • Bert Bravenboer
  • Suzannah Bumpstead
  • Noisel P. Burtt
  • Guillaume Charpentier
  • Peter S. Chines
  • Marilyn Cornelis
  • David J. Couper
  • Gabe Crawford
  • Alex S. F. Doney
  • Katherine S. Elliott
  • Amanda L. Elliott
  • Michael R. Erdos
  • Caroline S. Fox
  • Christopher S. Franklin
  • Martha Ganser
  • Christian Gieger
  • Niels Grarup
  • Todd Green
  • Simon Griffin
  • Christopher J. Groves
  • Candace Guiducci
  • Samy Hadjadj
  • Neelam Hassanali
  • Christian Herder
  • Bo Isomaa
  • Anne U. Jackson
  • Paul R. V. Johnson
  • Torben Jorgensen
  • Wen H. L. Kao
  • Norman Klopp
  • Augustine Kong
  • Peter Kraft
  • Johanna Kuusisto
  • Torsten Lauritzen
  • Man Li
  • Aloysius Lieverse
  • Cecilia M. Lindgren
  • Valeriya Lyssenko
  • Michel Marre
  • Thomas Meitinger
  • Kristian Midthjell
  • Mario A. Morken
  • Narisu Narisu
  • Peter Nilsson
  • Katharine R. Owen
  • Felicity Payne
  • John R. B. Perry
  • Ann-Kristin Petersen
  • Carl Platou
  • Christine Proenca
  • Inga Prokopenko
  • Wolfgang Rathmann
  • N. William Rayner
  • Neil R. Robertson
  • Ghislain Rocheleau
  • Michael Roden
  • Michael J. Sampson
  • Richa Saxena
  • Beverley M. Shields
  • Peter Shrader
  • Gunnar Sigurdsson
  • Thomas Sparso
  • Klaus Strassburger
  • Heather M. Stringham
  • Qi Sun
  • Amy J. Swift
  • Barbara Thorand
  • Jean Tichet
  • Tiinamaija Tuomi
  • Rob M. van Dam
  • Timon W. van Haeften
  • Thijs van Herpt
  • Jana V. van Vliet-Ostaptchouk
  • G. Bragi Walters
  • Michael N. Weedon
  • Cisca Wijmenga
  • Jacqueline Witteman
  • Richard N. Bergman
  • Stephane Cauchi
  • Francis S. Collins
  • Anna L. Gloyn
  • Ulf Gyllensten
  • Torben Hansen
  • Winston A. Hide
  • Graham A. Hitman
  • Albert Hofman
  • David J. Hunter
  • Kristian Hveem
  • Markku Laakso
  • Karen L. Mohlke
  • Andrew D. Morris
  • Colin N. A. Palmer
  • Peter P. Pramstaller
  • Igor Rudan
  • Eric Sijbrands
  • Lincoln D. Stein
  • Jaakko Tuomilehto
  • Andre Uitterlinden
  • Mark Walker
  • Nicholas J. Wareham
  • Richard M. Watanabe
  • Goncalo R. Abecasis
  • Bernhard O. Boehm
  • Harry Campbell
  • Mark J. Daly
  • Andrew T. Hattersley
  • Frank B. Hu
  • James B. Meigs
  • James S. Pankow
  • Oluf Pedersen
  • H-Erich Wichmann
  • Ines Barroso
  • Jose C. Florez
  • Timothy M. Frayling
  • Leif Groop
  • Rob Sladek
  • Unnur Thorsteinsdottir
  • James F. Wilson
  • Thomas Illig
  • Philippe Froguel
  • Cornelia M. van Duijn
  • Kari Stefansson
  • David Altshuler
  • Michael Boehnke
  • Mark I. McCarthy

Summary, in English

By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a further 34,412 cases and 59,925 controls, we identified 12 new T2D association signals with combined P < 5 x 10(-8). These include a second independent signal at the KCNQ1 locus; the first report, to our knowledge, of an X-chromosomal association (near DUSP9); and a further instance of overlap between loci implicated in monogenic and multifactorial forms of diabetes (at HNF1A). The identified loci affect both beta-cell function and insulin action, and, overall, T2D association signals show evidence of enrichment for genes involved in cell cycle regulation. We also show that a high proportion of T2D susceptibility loci harbor independent association signals influencing apparently unrelated complex traits.

Department/s

  • Genomics, Diabetes and Endocrinology
  • Internal Medicine - Epidemiology
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2010

Language

English

Pages

155-579

Publication/Series

Nature Genetics

Volume

42

Issue

7

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Endocrinology and Diabetes
  • Other Clinical Medicine

Status

Published

Research group

  • Genomics, Diabetes and Endocrinology
  • Internal Medicine - Epidemiology

ISBN/ISSN/Other

  • ISSN: 1546-1718