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Leif Groop

Leif Groop

Principal investigator

Leif Groop

Identification of ten loci associated with height highlights new biological pathways in human growth

Author

  • Guillaume Lettre
  • Anne U. Jackson
  • Christian Gieger
  • Fredrick R. Schumacher
  • Sonja I. Berndt
  • Serena Sanna
  • Susana Eyheramendy
  • Benjamin F. Voight
  • Johannah L. Butler
  • Candace Guiducci
  • Thomas Illig
  • Rachel Hackett
  • Iris M. Heid
  • Kevin B. Jacobs
  • Valeriya Lyssenko
  • Manuela Uda
  • Michael Boehnke
  • Stephen J. Chanock
  • Leif Groop
  • Frank B. Hu
  • Bo Isomaa
  • Peter Kraft
  • Leena Peltonen
  • Veikko Salomaa
  • David Schlessinger
  • David J. Hunter
  • Richard B. Hayes
  • Goncalo R. Abecasis
  • H-Erich Wichmann
  • Karen L. Mohlke
  • Joel N. Hirschhorn

Summary, in English

Height is a classic polygenic trait, reflecting the combined influence of multiple as-yet- undiscovered genetic factors. We carried out a meta-analysis of genome-wide association study data of height from 15,821 individuals at 2.2 million SNPs, and followed up the strongest findings in 410,000 subjects. Ten newly identified and two previously reported loci were strongly associated with variation in height (P values from 4 x 10(-7) to 8 x 10(-22)). Together, these 12 loci account for similar to 2% of the population variation in height. Individuals with <= 8 height-increasing alleles and >= 16 height-increasing alleles differ in height by similar to 3.5 cm. The newly identified loci, along with several additional loci with strongly suggestive associations, encompass both strong biological candidates and unexpected genes, and highlight several pathways (let-7 targets, chromatin remodeling proteins and Hedgehog signaling) as important regulators of human stature. These results expand the picture of the biological regulation of human height and of the genetic architecture of this classical complex trait.

Department/s

  • Genomics, Diabetes and Endocrinology

Publishing year

2008

Language

English

Pages

584-591

Publication/Series

Nature Genetics

Volume

40

Issue

5

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Endocrinology and Diabetes

Status

Published

Research group

  • Genomics, Diabetes and Endocrinology

ISBN/ISSN/Other

  • ISSN: 1546-1718