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Leif Groop

Leif Groop

Principal investigator

Leif Groop

Relationship between abdominal fat compartments and glucose and lipid metabolism in early postmenopausal women

Author

  • M Rendell
  • U L Hulthen
  • C Törnquist
  • Leif Groop
  • Ingrid Mattiasson

Summary, in English

The relationships between abdominal and pelvic fat compartments and glucose and lipid metabolism were investigated in early postmenopausal women. Fifty-five healthy, postmenopausal women aged 52-53 yr participated in the study. Fat distribution (intra-abdominal and sc abdominal fat, and intrapelvic and sc pelvic fat) was estimated by computed tomography. Insulin sensitivity was assessed by euglycemic hyperinsulinemic clamp. In a multiple regression analysis, the size of the intra-abdominal fat compartment was the only significant predictor of insulin sensitivity (r(2) = 24%; P = 0.0002). Plasma triglycerides were closely related to the size of the intra-abdominal fat compartment (r(2) = 26%; P < 0.0001), whereas plasma free fatty acid concentrations only correlated to the size of the sc abdominal fat compartment (r(2) = 18.5%, P = 0.001). In early postmenopausal women the amount of the intra-abdominal fat strongly influences insulin sensitivity and plasma triglyceride levels, whereas plasma free fatty acids are closely related to the amount of the sc abdominal fat. Accordingly, from a metabolic standpoint it seems most essential to reduce intra-abdominal fat in postmenopausal women.

Department/s

  • Genomics, Diabetes and Endocrinology
  • Vascular Diseases - Clinical Research

Publishing year

2001

Language

English

Pages

744-749

Publication/Series

Journal of Clinical Endocrinology and Metabolism

Volume

86

Issue

2

Document type

Journal article

Publisher

Oxford University Press

Topic

  • Cardiac and Cardiovascular Systems
  • Endocrinology and Diabetes

Status

Published

Research group

  • Genomics, Diabetes and Endocrinology
  • Vascular Diseases - Clinical Research

ISBN/ISSN/Other

  • ISSN: 1945-7197